| Tag |
Content |
| dbPAF ID |
dbPAF-0003089 |
| Uniprot Accession |
O88618; FTCD_RAT; Q5BKB7;
|
| Genbank Protein ID |
NP_446019.1;
|
| Genbank Nucleotide ID |
NM_053567.1;
|
| Protein Name |
Formimidoyltransferase-cyclodeaminase |
| Protein Synonyms/Alias |
58 kDa microtubule-binding protein;Formiminotransferase-cyclodeaminase;FTCD; |
| Gene Name |
Ftcd |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity).Functional Description
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MSQLVECVPN FSEGNNQEVI DAISQAISQT PGCVLLDVDA GPSTNRTVYT FVGQPECVVE 60
GALSAARTAS QLIDMRKHKG EHPRMGALDV CPFIPVRGVS MDECVLCAKA FGQRLAEELN 120
VPVYLYGEAA QMPSRQTLPA IRAGEYEALP EKLKQAEWVP DFGPSSFVPS WGATVTGARK 180
FLIAFNINLL STKEQAHRIA LNLREQGRGK DQPGRLKKVQ GIGWYLEEKN LAQVSTNLLD 240
FEVTALHTVY EEARREAQEL NLPVVGSQLV GLVPLKALLD AAAFYCDKEK LFVLEEEHRI 300
RLVVNRLGLD SLAPFDPKER IIEYLVPDSG PEQSLLDASL RAFVREVGAR SAAPGGGSVA 360
AAVAALGAAL ASMVGQMTYG RRQFDHLDST MRRLIPPFHA ASAQLTSLVD ADARAFAACL 420
GAIKLPKNTP EERDRRTCAL QEGLRQAVAV PLKLAETVSQ LWPALQELAQ CGNLSCLSDL 480
QVAAKALETG VFGAYFNVLI NLKDMTDDVF KEKTRHRISS LLQEAKTQAA LVLGSLEARK 540
E
542Fasta Sequence
>O88618|Ftcd|Rattus norvegicus(Rat)
MSQLVECVPNFSEGNNQEVIDAISQAISQTPGCVLLDVDAGPSTNRTVYTFVGQPECVVEGALSAARTASQLIDMRKHKGEHPRMGALDVCPFIPVRGVSMDECVLCAKAFGQRLAEELNVPVYLYGEAAQMPSRQTLPAIRAGEYEALPEKLKQAEWVPDFGPSSFVPSWGATVTGARKFLIAFNINLLSTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLEEKNLAQVSTNLLDFEVTALHTVYEEARREAQELNLPVVGSQLVGLVPLKALLDAAAFYCDKEKLFVLEEEHRIRLVVNRLGLDSLAPFDPKERIIEYLVPDSGPEQSLLDASLRAFVREVGARSAAPGGGSVAAAVAALGAALASMVGQMTYGRRQFDHLDSTMRRLIPPFHAASAQLTSLVDADARAFAACLGAIKLPKNTPEERDRRTCALQEGLRQAVAVPLKLAETVSQLWPALQELAQCGNLSCLSDLQVAAKALETGVFGAYFNVLINLKDMTDDVFKEKTRHRISSLLQEAKTQAALVLGSLEARKE
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0290--Folate-binding
KW-0333--Golgi apparatus
KW-0369--Histidine metabolism
KW-0456--Lyase
KW-0511--Multifunctional enzyme
KW-0597--Phosphoprotein
KW-0663--Pyridoxal phosphate
KW-1185--Reference proteome
KW-0808--Transferase
|
| Interpro |
IPR007044--Cyclodeamin/CycHdrlase
IPR013802--Formiminotransferase_C
IPR004227--Formiminotransferase_cat
IPR012886--Formiminotransferase_N
IPR022384--FormiminoTrfase_subdom
|
| PROSITE |
|
| Pfam |
PF02971--FTCD
PF04961--FTCD_C
PF07837--FTCD_N
|
| Gene Ontology |
GO:0005814--C:centriole
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005793--C:endoplasmic reticulum-Golgi intermediate compartment
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0030868--C:smooth endoplasmic reticulum membrane
GO:0005542--F:folic acid binding
GO:0030412--F:formimidoyltetrahydrofolate cyclodeaminase activity
GO:0030407--F:formimidoyltransferase activity
GO:0030409--F:glutamate formimidoyltransferase activity
GO:0019215--F:intermediate filament binding
GO:0008017--F:microtubule binding
GO:0007010--P:cytoskeleton organization
GO:0019556--P:histidine catabolic process to glutamate and formamide
GO:0019557--P:histidine catabolic process to glutamate and formate
GO:0035999--P:tetrahydrofolate interconversion
|
