dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003087
Uniprot Accession O88600; HSP74_RAT;
Genbank Protein ID NP_705893.1;
Genbank Nucleotide ID NM_153629.1;
Protein Name Heat shock 70 kDa protein 4
Protein Synonyms/Alias Ischemia responsive 94 kDa protein;
Gene Name Hspa4
Gene Synonyms/Alias Irp94;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
40RCTPACVSFGPKNRScurated23984901
63VISNAKNTVQGFKRFcurated23984901
76RFHGRAFSDPFVEAEPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521; 22817900
184VALAYGIYKQDLPALPhosphoSitePlus22135298
229VLATAFDTTLGGRKFcurated23984901
336KLKKEDIYAVEIVGGPhosphoSitePlus22135298
384ALQCAILSPAFKVREcurated23984901
393AFKVREFSITDVVPYcurated23984901
408PISLRWNSPAEEGSScurated23984901
538TEEQQPQTPAENKAEPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457; 22276854; 23984901
546PAENKAESEEMETSQcurated23712012; 21630457
Sequence
(Fasta)		MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACVS FGPKNRSVGA AAKSQVISNA 60
KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG IKVTYMEEER NFTTEQVTAM 120
LLSKLKETAE SVLKKPVVDC VVSVPSFYTD AERRSVMDAT QIAGLNCLRL MNETTAVALA 180
YGIYKQDLPA LEEKPRNVVF VDMGHSAYQV SVCAFNRGKL KVLATAFDTT LGGRKFDEVL 240
VNHFCEEFGK KYKLDIKSKV RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDIDVSGT 300
MNRGKFLEMC DDLLARVEPP LRSILDQSKL KKEDIYAVEI VGGATRIPAV KEKISKFFGK 360
ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY PISLRWNSPA EEGSSDCEVF 420
PKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV 480
KVRVNVHGIF SVSSAALVEV HKSEESEEPM ETDQNAKEEE KMQVDQEEPH TEEQQPQTPA 540
ENKAESEEME TSQAGSKDKK MDQPPQAKKA KVKTSTVDLP IESQLLWQLD REMLGLYTEN 600
EGKMIMQDKL EKERNDAKNA VEEYVYEMRD KLSGEYEKFV SEDDRNNFTL KLEDTENWLY 660
EDGEDQPKQV YVDKLAELRT LGQPIKTRFQ ESEERPKLFE ELGKQIQQYM KVISSFKNKE 720
DQYEHLDAAD MTKVEKSTNE AMEWMNSKLN LQNKQSLTAD PVVKTKEIEA KIKELTNICS 780
PIISKPKPKV EPPKEEPKHA EQNGPVDGQG DNPGTQAAEH GADTAVPSDG DKKLPEMDID 840
841
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0346--Stress response
Interpro

IPR018181--Heat_shock_70_CS
IPR029048--HSP70_C
IPR029047--HSP70_peptide-bd
IPR013126--Hsp_70_fam
PROSITE

PS00329--HSP70_2
PS01036--HSP70_3
Pfam

PF00012--HSP70
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0033613--F:activating transcription factor binding
GO:0005524--F:ATP binding
GO:0032403--F:protein complex binding
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0001822--P:kidney development
GO:0043066--P:negative regulation of apoptotic process
GO:0060548--P:negative regulation of cell death
GO:0043392--P:negative regulation of DNA binding
GO:0010629--P:negative regulation of gene expression
GO:0001933--P:negative regulation of protein phosphorylation
GO:0045766--P:positive regulation of angiogenesis
GO:0010628--P:positive regulation of gene expression
GO:0032092--P:positive regulation of protein binding
GO:0009408--P:response to heat