dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003084
Uniprot Accession O88588; PACS1_RAT; O88589;
Genbank Protein ID NP_599233.1;
Genbank Nucleotide ID NM_134406.1;
Protein Name Phosphofurin acidic cluster sorting protein 1
Protein Synonyms/Alias
Gene Name Pacs1
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits.
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
28RGSGVAQSPQQQPPQPhosphoSitePlus22135298
249PVAEIKIYSLSSQPIPhosphoSitePlus22135298
377SLEMYNPSDSGPEMEPhosphoSitePlus;UniProt22135298; 22673903
379EMYNPSDSGPEMEETPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457
409EGMSQSSSQTEIGSLcurated23984901
493ADLQGSASPSKVEGTPhosphoSitePlus22135298
495LQGSASPSKVEGTHTcurated23984901
524SKPLSERTNSSDSERcurated23984901; 24945867
526PLSERTNSSDSERSPPhosphoSitePlus;UniProt;curated22135298; 22673903; 24945867
527LSERTNSSDSERSPDPhosphoSitePlus;UniProt;curated22135298; 22673903; 24945867
529ERTNSSDSERSPDLGcurated21630457
532NSSDSERSPDLGHSTPhosphoSitePlus;curated22135298; 21630457
958PVGLFSGSKPT----PhosphoSitePlus22135298
Sequence
(Fasta)		MAERGGAGGG PGGAGGGSSQ RGSGVAQSPQ QQPPQQPSQP QQPTPPKLAQ ATSSSSSTSA 60
AAASSSSSST STSMAVAVAS GSAPPGGPGP GRTPAPVQMN LYATWEVDRS SSSCVPRLFS 120
LTLKKLVMLK EMDKDLNSVV IAVKLQGSKR ILRSNEIILP ASGLVETELQ LTFSLQYPHF 180
LKRDANKLQI MLQRRKRYKN RTILGYKTLA VGLINMAEVM QHPNEGALVL GLHSNVKDVS 240
VPVAEIKIYS LSSQPIDHEG IKSKLSDRSP DIDNYSEEEE ESFSSEQEGS DDPLHGQDLF 300
YEDEDLRKVK KTRRKLTSTS AITRQPNIKQ KFVALLKRFK VSDEVGFGLE HVSREQIREV 360
EEDLDELYDS LEMYNPSDSG PEMEETESIL STPKPKLKPF FEGMSQSSSQ TEIGSLNSKG 420
SLGKDTTSPM ELAALEKVKS TWIKNQDDSL TETDTLEITD QDMFGDASTS LVVPEKVKTP 480
MKSSKADLQG SASPSKVEGT HTPRQKRSTP LKERQLSKPL SERTNSSDSE RSPDLGHSTQ 540
IPRKVVYDQL NQILVSDAAL PENVILVNTT DWQGQYVAEL LQDQRKPVVC TCSTVEVQAV 600
LSALLTRIQR YCNCNSSMPR PVKVAAVGSQ SYLSSILRFF VKSLASKTPD WLGHMRFLIV 660
PLGSHPVAKY LGSVDSRYSS TFLDSAWRDL FSRSEPPVSE PLDVVGRVMQ YVNGATTTHQ 720
LPVAEAMLTC RHKFPDEDSY QKFIPFIGVV KVGLVEDSPS TAGDGDDSPV VSLTVPSTSP 780
PSSSGLSRDA TATPPSSPSM SSALAIVGSP NSPYGDVIGL QVDYWLGHPG ERRREGDKRD 840
ASSKNTLKSV FRSVQVSRLP HAGEAQLSGT MAMTVVTKEK NKKVPTIFLS KKPREKEVDS 900
KSQVIEGISR LICSAKQQQT MLRVSIDGVE WSDIKFFQLA AQWPTHVKHF PVGLFSGSKP 960
T 962
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR019381--Phosphofurin_acidic_CS-1
PROSITE
Pfam

PF10254--Pacs-1
Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0044325--F:ion channel binding
GO:0034613--P:cellular protein localization
GO:0032092--P:positive regulation of protein binding
GO:0072661--P:protein targeting to plasma membrane