| Tag |
Content |
| dbPAF ID |
dbPAF-0003076 |
| Uniprot Accession |
O88563; MRP3_RAT; O88270;
|
| Genbank Protein ID |
NP_542148.1;
|
| Genbank Nucleotide ID |
NM_080581.1;
|
| Protein Name |
Canalicular multispecific organic anion transporter 2 |
| Protein Synonyms/Alias |
ATP-binding cassette sub-family C member 3;MRP-like protein 2;MLP-2;Multidrug resistance-associated protein 3; |
| Gene Name |
Abcc3 |
| Gene Synonyms/Alias |
Cmoat2;Mlp2;Mrp3; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).Functional Description
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MDRLCGSGEL GSKFWDSNLT VYTNTPDLTP CFQNSLLAWV PCIYLWAALP CYLFYLRHHR 60
LGYIVLSCLS RLKTALGVLL WCISWVDLFY SFHGLVHGSS PAPVFFITPL LVGITMLLAT 120
LLIQYERLRG VRSSGVLIIF WLLCVICAII PFRSKILLAL AEGKILDPFR FTTFYIYFAL 180
VLCAFILSCF QEKPPLFSPE NLDTNPCPEA SAGFFSRLSF WWFTKLAILG YRRPLEDSDL 240
WSLSEEDCSH KVVQRLLEAW QKQQTQASGP QTAALEPKIA GEDEVLLKAR PKTKKPSFLR 300
ALVRTFTSSL LMGACFKLIQ DLSPSSTHSC SASSSGLFRP HGPYWWGFLL AGLMFVSSTM 360
QTLILHQHYH CIFVMALRIR TAIIGVIYRK ALTITNSVKR EYTVGEMVNL MSVDAQRFMD 420
VSPFINLLWS APLQVILAIY FLWQILGPSA LAGVAVIVLL IPLNGAVSMK MKTYQVQQMK 480
FKDSRIKLMS EILNGIKVLK LYAWEPTFLE QVEGIRQGEL QLLRKGAYLQ AISTFIWVCT 540
PFMVTLITLG VYVCVDKNNV LDAEKAFVSL SLFNILKIPL NLLPQLISGM TQTSVSLKRI 600
QDFLNQDELD PQCVERKTIS PGRAITIHNG TFSWSKDLPP TLHSINIQIP KGALVAVVGP 660
VGCGKSSLVS ALLGEMEKLE GAVSVKGSVA YVPQQAWIQN CTLQENVLFG QPMNPKRYQQ 720
ALETCALLAD LDVLPGGDQT EIGEKGINLS GGQRQRVSLA RAVYSDANIF LLDDPLSAVD 780
SHVAKHIFDQ VIGPEGVLAG KTRVLVTHGI SFLPQTDFII VLADGQITEM GHYSELLQHD 840
GSFANFLRNY APDENQEANE GVLQHANEEV LLLEDTLSTH TDLTDTEPAI YEVRKQFMRE 900
MSSLSSEGEG QNRPVLKRYT SSLEKEVPAT QTKETGALIK EEIAETGNVK LSVYWDYAKS 960
VGLCTTLFIC LLYAGQNAVA IGANVWLSAW TNDVEEHGQQ NNTSVRLGVY ATLGILQGLL 1020
VMLSAFTMVV GAIQAARLLH TALLHNQIRA PQSFFDTTPS GRILNRFSKD IYVIHEVLAP 1080
TILMLFNSFY TSISTIVVIV ASTPLFCVVV LPLAVFYGFV QRFYVATSRQ LKRLESVSRS 1140
PIFSHFSETV TGTSVIRAYG RVQDFKVLSD AKVDSNQKTT YPYIASNRWL GVHVEFVGNC 1200
VVLFSALFAV IGRNSLNPGL VGLSVSYALQ VTLSLNWMIR TLSDLESNII AVERVKEYSK 1260
TETEAPWVLE SNRAPEGWPR SGVVEFRNYS VRYRPGLELV LKNLTLHVQG GEKVGIVGRT 1320
GAGKSSMTLC LFRILEAAEG EIFIDGLNVA HIGLHDLRSQ LTIIPQDPIL FSGTLRMNLD 1380
PFGRYSDEDI WRTLELSHLS AFVSSQPTGL DFQCSEGGDN LSVGQRQLVC LARALLRKSR 1440
VLVLDEATAA IDLETDDLIQ GTIRTQFEDC TVLTIAHRLN TIMDYNRVLV LDKGVVAEFD 1500
SPVNLIAAGG IFYGMAKDAG LA
1523Fasta Sequence
>O88563|Abcc3|Rattus norvegicus(Rat)
MDRLCGSGELGSKFWDSNLTVYTNTPDLTPCFQNSLLAWVPCIYLWAALPCYLFYLRHHRLGYIVLSCLSRLKTALGVLLWCISWVDLFYSFHGLVHGSSPAPVFFITPLLVGITMLLATLLIQYERLRGVRSSGVLIIFWLLCVICAIIPFRSKILLALAEGKILDPFRFTTFYIYFALVLCAFILSCFQEKPPLFSPENLDTNPCPEASAGFFSRLSFWWFTKLAILGYRRPLEDSDLWSLSEEDCSHKVVQRLLEAWQKQQTQASGPQTAALEPKIAGEDEVLLKARPKTKKPSFLRALVRTFTSSLLMGACFKLIQDLSPSSTHSCSASSSGLFRPHGPYWWGFLLAGLMFVSSTMQTLILHQHYHCIFVMALRIRTAIIGVIYRKALTITNSVKREYTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVQQMKFKDSRIKLMSEILNGIKVLKLYAWEPTFLEQVEGIRQGELQLLRKGAYLQAISTFIWVCTPFMVTLITLGVYVCVDKNNVLDAEKAFVSLSLFNILKIPLNLLPQLISGMTQTSVSLKRIQDFLNQDELDPQCVERKTISPGRAITIHNGTFSWSKDLPPTLHSINIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGAVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQITEMGHYSELLQHDGSFANFLRNYAPDENQEANEGVLQHANEEVLLLEDTLSTHTDLTDTEPAIYEVRKQFMREMSSLSSEGEGQNRPVLKRYTSSLEKEVPATQTKETGALIKEEIAETGNVKLSVYWDYAKSVGLCTTLFICLLYAGQNAVAIGANVWLSAWTNDVEEHGQQNNTSVRLGVYATLGILQGLLVMLSAFTMVVGAIQAARLLHTALLHNQIRAPQSFFDTTPSGRILNRFSKDIYVIHEVLAPTILMLFNSFYTSISTIVVIVASTPLFCVVVLPLAVFYGFVQRFYVATSRQLKRLESVSRSPIFSHFSETVTGTSVIRAYGRVQDFKVLSDAKVDSNQKTTYPYIASNRWLGVHVEFVGNCVVLFSALFAVIGRNSLNPGLVGLSVSYALQVTLSLNWMIRTLSDLESNIIAVERVKEYSKTETEAPWVLESNRAPEGWPRSGVVEFRNYSVRYRPGLELVLKNLTLHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIFIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSDEDIWRTLELSHLSAFVSSQPTGLDFQCSEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAAGGIFYGMAKDAGLA
|
| Keyword |
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR003593--AAA+_ATPase
IPR011527--ABC1_TM_dom
IPR003439--ABC_transporter-like
IPR017871--ABC_transporter_CS
IPR030242--ABCC3
IPR005292--Multidrug-R_assoc
IPR027417--P-loop_NTPase
|
| PROSITE |
PS50929--ABC_TM1F
PS00211--ABC_TRANSPORTER_1
PS50893--ABC_TRANSPORTER_2
|
| Pfam |
PF00664--ABC_membrane
PF00005--ABC_tran
|
| Gene Ontology |
GO:0016323--C:basolateral plasma membrane
GO:0016021--C:integral component of membrane
GO:0005524--F:ATP binding
GO:0042626--F:ATPase activity, coupled to transmembrane movement of substances
GO:0015432--F:bile acid-exporting ATPase activity
GO:0015238--F:drug transmembrane transporter activity
GO:0008559--F:xenobiotic-transporting ATPase activity
GO:0015722--P:canalicular bile acid transport
GO:0006855--P:drug transmembrane transport
GO:0015893--P:drug transport
GO:0032355--P:response to estradiol
GO:0032496--P:response to lipopolysaccharide
GO:0014070--P:response to organic cyclic compound
GO:0010033--P:response to organic substance
GO:0010243--P:response to organonitrogen compound
GO:0042908--P:xenobiotic transport
|
