| Tag |
Content |
| dbPAF ID |
dbPAF-0003059 |
| Uniprot Accession |
O88506; STK39_RAT; O70541;
|
| Genbank Protein ID |
NP_062235.1;
|
| Genbank Nucleotide ID |
NM_019362.1;
|
| Protein Name |
STE20/SPS1-related proline-alanine-rich protein kinase |
| Protein Synonyms/Alias |
|
| Gene Name |
Stk39 |
| Gene Synonyms/Alias |
Pask;Spak; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation.Functional Description
May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MAEPSGSPVH VQLPQQAAPV TAAAAAPAAA TSAPAPAPAP AAPAAPAPAP AAAPAPAPAA 60
QAVGWPICRD AYELQEVIGS GATAVVQAAL CKPRQERVAI KRINLEKCQT SMDELLKEIQ 120
AMSQCSHPNV VTYYTSFVVK DELWLVMKLL SGGSMLDIIK YIVNRGEHKN GVLEEAIIAT 180
ILKEVLEGLD YLHRNGQIHR DLKAGNILLG EDGSVQIADF GVSAFLATGG DVTRNKVRKT 240
FVGTPCWMAP EVMEQVRGYD FKADMWSFGI TAIELATGAA PYHKYPPMKV LMLTLQNDPP 300
TLETGVEDKE MMKKYGKSFR KLLSLCLQKD PSKRPTAAEL LKCKFFQKAK NREYLIEKLL 360
TRTPDIAQRA KKVRRVPGSS GHLHKTEDGD WEWSDDEMDE KSEEGKAAAS QEKSRRVKEE 420
NPEISVNAGG IPEQIQSLSV HDSQGQPNAN EDYREGPCAV NLVLRLRNSR KELNDIRFEF 480
TPGRDTADGV SQELFSAGLV DGHDVVIVAA NLQKIVDDPK ALKTLTFKLA SGCDGAEIPD 540
EVKLIGFAQL SVS
554Fasta Sequence
>O88506|Stk39|Rattus norvegicus(Rat)
MAEPSGSPVHVQLPQQAAPVTAAAAAPAAATSAPAPAPAPAAPAAPAPAPAAAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAASQEKSRRVKEENPEISVNAGGIPEQIQSLSVHDSQGQPNANEDYREGPCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGAEIPDEVKLIGFAQLSVS
|
| Keyword |
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
|
| Interpro |
IPR011009--Kinase-like_dom
IPR024678--Kinase_OSR1/WNK_CCT
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
|
| PROSITE |
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
|
| Pfam |
PF12202--OSR1_C
PF00069--Pkinase
|
| Gene Ontology |
GO:0016324--C:apical plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0032147--P:activation of protein kinase activity
GO:0071476--P:cellular hypotonic response
GO:0090188--P:negative regulation of pancreatic juice secretion
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:2000687--P:negative regulation of rubidium ion transmembrane transporter activity
GO:0018105--P:peptidyl-serine phosphorylation
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0043268--P:positive regulation of potassium ion transport
GO:0006468--P:protein phosphorylation
GO:0042981--P:regulation of apoptotic process
GO:0008217--P:regulation of blood pressure
GO:0050727--P:regulation of inflammatory response
GO:2000021--P:regulation of ion homeostasis
GO:0007346--P:regulation of mitotic cell cycle
GO:0023014--P:signal transduction by protein phosphorylation
GO:0031098--P:stress-activated protein kinase signaling cascade
|
