dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0003057
Uniprot Accession O88498; B2L11_RAT; O88497; Q9WUI8;
Genbank Protein ID NP_072134.1; NP_741985.1; NP_741986.1;
Genbank Nucleotide ID NM_022612.1; NM_171988.2; NM_171989.1;
Protein Name Bcl-2-like protein 11
Protein Synonyms/Alias
Gene Name Bcl2l11
Gene Synonyms/Alias Bim;Bod;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Induces apoptosis and anoikis.
Phosphorylation Sites
dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
55GDRCPHGSPQGPLAPdbPTM 3.0;PhosphoSitePlus15470142; 16381945; 23193290; 22135298
65GPLAPPASPGPFATRdbPTM 3.0;PhosphoSitePlus14681225; 15470142; 15728578; 16504941; 16818494; 16381945;
73PGPFATRSPLFIFVRPhosphoSitePlus;UniProt22135298; 22673903
83FIFVRRSSLLSRSSSPhosphoSitePlus;UniProt22135298; 22673903
100FSFDTDRSPAPMSCDdbPTM 3.0;PhosphoSitePlus15470142; 16381945; 23193290; 22135298
109APMSCDKSTQTPSPPdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus12388545; 16381945; 23193290; 22135298
110PMSCDKSTQTPSPPCdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus12388545; 16381945; 23193290; 22135298
112SCDKSTQTPSPPCQAdbPTM 3.0;PhosphoSitePlus15470142; 16381945; 23193290; 22135298
Sequence
(Fasta)
MAKQPSDVNS ECDREGGQLQ PAERPPQLRP GAPTSLQTES QGNPDGEGDR CPHGSPQGPL 60
APPASPGPFA TRSPLFIFVR RSSLLSRSSS GYFSFDTDRS PAPMSCDKST QTPSPPCQAF 120
NHYLSAMASI RQSQEEPEDL RPEIRIAQEL RRIGDEFNET YTRRAFANDY REAEDHPQMV 180
ILQLLRFIFR LVWRRH 197
Keyword

KW-0024--Alternative initiation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR014771--Apoptosis_Bim_N
IPR017288--Bcl-2-like_11
IPR015040--Bcl-x_interacting_BH3_dom

PROSITE
Pfam

PF08945--Bclx_interact
PF06773--Bim_N

Gene Ontology

GO:0097141--C:BIM-BCL-2 complex
GO:0097140--C:BIM-BCL-xl complex
GO:0005829--C:cytosol
GO:0019898--C:extrinsic component of membrane
GO:0005874--C:microtubule
GO:0005739--C:mitochondrion
GO:0008017--F:microtubule binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1902263--P:apoptotic process involved in embryonic digit morphogenesis
GO:0001783--P:B cell apoptotic process
GO:0001782--P:B cell homeostasis
GO:0007420--P:brain development
GO:0007160--P:cell-matrix adhesion
GO:0060154--P:cellular process regulating host cell cycle in response to virus
GO:0048066--P:developmental pigmentation
GO:0043583--P:ear development
GO:0097192--P:extrinsic apoptotic signaling pathway in absence of ligand
GO:0001701--P:in utero embryonic development
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001822--P:kidney development
GO:0008584--P:male gonad development
GO:0030879--P:mammary gland development
GO:0002262--P:myeloid cell homeostasis
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0043065--P:positive regulation of apoptotic process
GO:0060139--P:positive regulation of apoptotic process by virus
GO:0045787--P:positive regulation of cell cycle
GO:0010942--P:positive regulation of cell death
GO:2000271--P:positive regulation of fibroblast apoptotic process
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:1902110--P:positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0032464--P:positive regulation of protein homooligomerization
GO:0090200--P:positive regulation of release of cytochrome c from mitochondria
GO:0048563--P:post-embryonic organ morphogenesis
GO:0048070--P:regulation of developmental pigmentation
GO:0046620--P:regulation of organ growth
GO:0034976--P:response to endoplasmic reticulum stress
GO:0007283--P:spermatogenesis
GO:0048536--P:spleen development
GO:0043029--P:T cell homeostasis
GO:0070242--P:thymocyte apoptotic process
GO:0048538--P:thymus development
GO:0035148--P:tube formation