dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0003047 |
| Uniprot Accession | O88457; SCNBA_RAT; |
| Genbank Protein ID | NP_062138.1; |
| Genbank Nucleotide ID | NM_019265.2; |
| Protein Name | Sodium channel protein type 11 subunit alpha |
| Protein Synonyms/Alias | NaN;Sensory neuron sodium channel 2;Sodium channel protein type XI subunit alpha;Voltage-gated sodium channel subunit alpha Nav1.9; |
| Gene Name | Scn11a |
| Gene Synonyms/Alias | Nan;Sns2; |
| Organism | Rattus norvegicus(Rat) |
| NCBI Taxa ID | 10116 |
| Functional Description (View all) |
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization (By similarity). |
| Phosphorylation Sites |
dbPAF PTMs: 4 |
| Sequence (Fasta) | MEERYYPVIF PDERNFRPFT SDSLAAIEKR IAIQKERKKS KDKAAAEPQP RPQLDLKASR 60 KLPKLYGDIP PELVAKPLED LDPFYKDHKT FMVLNKKRTI YRFSAKRALF ILGPFNPLRS 120 LMIRISVHSV FSMFIICTVI INCMFMANSM ERSFDNDIPE YVFIGIYILE AVIKILARGF 180 IVDEFSFLRD PWNWLDFIVI GTAIATCFPG SQVNLSALRT FRVFRALKAI SVISGLKVIV 240 GALLRSVKKL VDVMVLTLFC LSIFALVGQQ LFMGILNQKC IKHNCGPNPA SNKDCFEKEK 300 DSEDFIMCGT WLGSRPCPNG STCDKTTLNP DNNYTKFDNF GWSFLAMFRV MTQDSWERLY 360 RQILRTSGIY FVFFFVVVIF LGSFYLLNLT LAVVTMAYEE QNRNVAAETE AKEKMFQEAQ 420 QLLREEKEAL VAMGIDRSSL NSLQASSFSP KKRKFFGSKT RKSFFMRGSK TAQASASDSE 480 DDASKNPQLL EQTKRLSQNL PVDLFDEHVD PLHRQRALSA VSILTITMQE QEKFQEPCFP 540 CGKNLASKYL VWDCSPQWLC IKKVLRTIMT DPFTELAITI CIIINTVFLA VEHHNMDDNL 600 KTILKIGNWV FTGIFIAEMC LKIIALDPYH YFRHGWNVFD SIVALLSLAD VLYNTLSDNN 660 RSFLASLRVL RVFKLAKSWP TLNTLIKIIG HSVGALGNLT VVLTIVVFIF SVVGMRLFGT 720 KFNKTAYATQ ERPRRRWHMD NFYHSFLVVF RILCGEWIEN MWGCMQDMDG SPLCIIVFVL 780 IMVIGKLVVL NLFIALLLNS FSNEEKDGSL EGETRKTKVQ LALDRFRRAF SFMLHALQSF 840 CCKKCRRKNS PKPKETTESF AGENKDSILP DARPWKEYDT DMALYTGQAG APLAPLAEVE 900 DDVEYCGEGG ALPTSQHSAG VQAGDLPPET KQLTSPDDQG VEMEVFSEED LHLSIQSPRK 960 KSDAVSMLSE CSTIDLNDIF RNLQKTVSPK KQPDRCFPKG LSCHFLCHKT DKRKSPWVLW 1020 WNIRKTCYQI VKHSWFESFI IFVILLSSGA LIFEDVNLPS RPQVEKLLRC TDNIFTFIFL 1080 LEMILKWVAF GFRRYFTSAW CWLDFLIVVV SVLSLMNLPS LKSFRTLRAL RPLRALSQFE 1140 GMKVVVYALI SAIPAILNVL LVCLIFWLVF CILGVNLFSG KFGRCINGTD INMYLDFTEV 1200 PNRSQCNISN YSWKVPQVNF DNVGNAYLAL LQVATYKGWL EIMNAAVDSR EKDEQPDFEA 1260 NLYAYLYFVV FIIFGSFFTL NLFIGVIIDN FNQQQKKLGG QDIFMTEEQK KYYNAMKKLG 1320 TKKPQKPIPR PLNKCQAFVF DLVTSQVFDV IILGLIVLNM IIMMAESADQ PKDVKKTFDI 1380 LNIAFVVIFT IECLIKVFAL RQHYFTNGWN LFDCVVVVLS IISTLVSRLE DSDISFPPTL 1440 FRVVRLARIG RILRLVRAAR GIRTLLFALM MSLPSLFNIG LLLFLVMFIY AIFGMSWFSK 1500 VKKGSGIDDI FNFETFTGSM LCLFQITTSA GWDTLLNPML EAKEHCNSSS QDSCQQPQIA 1560 VVYFVSYIII SFLIVVNMYI AVILENFNTA TEESEDPLGE DDFEIFYEVW EKFDPEASQF 1620 IQYSALSDFA DALPEPLRVA KPNKFQFLVM DLPMVMGDRL HCMDVLFAFT TRVLGDSSGL 1680 DTMKTMMEEK FMEANPFKKL YEPIVTTTKR KEEEQGAAVI QRAYRKHMEK MVKLRLKDRS 1740 SSSHQVFCNG DLSSLDVAKV KVHND 1766 |
| Keyword | KW-0181--Complete proteome |
| Interpro | IPR027359--Channel_four-helix_dom |
| PROSITE | |
| Pfam | |
| Gene Ontology | GO:0005886--C:plasma membrane |