dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003043
Uniprot Accession O88453; SAFB1_RAT;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Scaffold attachment factor B1
Protein Synonyms/Alias
Gene Name Safb
Gene Synonyms/Alias Safb1;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
11TLSGLGDSGAASAAAcurated23984901
24AAVSSAASETGTRRLPhosphoSitePlus;UniProt22135298; 22673903
195INNVDTSSSDFTILQPhosphoSitePlus;curated22135298; 23712012; 21630457
196NNVDTSSSDFTILQEcurated21630457
199DTSSSDFTILQEMEEcurated21630457
208LQEMEEASLEPENEKPhosphoSitePlus;UniProt22135298; 22673903
366RAPTAAPSPEPRDSKdbPTM 3.016396499; 16381945; 23193290; 17089331; 17683130; 18473453
437FWVSGLSSTTRATDLcurated23984901
623SVSREKRSVVSFDKVPhosphoSitePlus;curated22135298; 25532521; 23712012; 21630457; 23984901
626REKRSVVSFDKVKESdbPTM 3.0;PhosphoSitePlus;curated18779572; 16381945; 23193290; 22135298; 23712012; 21630457;
Sequence
(Fasta)		MAETLSGLGD SGAASAAAVS SAASETGTRR LSDLRVIDLR AELRKRNLTS SGNKSVLMER 60
LKKAIEEEGG NPDEIEVISE GNKKMPKRPS KGKKPEDEGV EDNGLEENSG DGQEDVETSL 120
ENLQDMDMMD ISVLDEADID NGSVADCVEE EEEATLPEGL GLLRIGRLQS KGLPEQLQEL 180
AIDDKEAINN VDTSSSDFTI LQEMEEASLE PENEKILDIL GETCKSEPVK EEGSELEQPF 240
AQATSSVGPD RKLAEEEDLF ESCGHPEEEE EEEEEEEQEE EQEEEGDLAL ASSSKSESSS 300
TRCQWSEADA LLAVVKREPA EAPGGGTGMD REPVGLEEPV EQSSTAAQLP ETTSQELVRA 360
PTAAPSPEPR DSKDDVKKFA FDACNDVPAA PKESSASEGA DQKMSSVEDD SDTKRLSREE 420
KGRSSCGRNF WVSGLSSTTR ATDLKNLFSR YGKVVGAKVV TNARSPGARC YGFVTMSTAE 480
EATKCINHLH KTELHGKMIS VEKAKSEPAG KRVPDRRDGD SKKEKTSTSD RSANLKREEK 540
GDRKDDAKKT DDGSTEKSKD ADDQKPGPSE RSRTTKSGSR GTERTVVMDK SKGVPVISVK 600
TSGSKERASK SQDRKSVSRE KRSVVSFDKV KESRKSRDSE SRRERERERS EREQRLQAQW 660
EREERERLEI ARERLAFHRH RLERERMERE RLERERMHVE QERRREQERI HREREELRRQ 720
QELRYEQERR PAVRRPYEVD GRRDDAYWPE AKRAALDDRY HSDFSRQDRF HDFDHRDRGR 780
YPNHSVDRRE GSRSMMGDRE GQHYPERHGG PERHGRDSRD GWGYGSNKRL SEGRGLPLLP 840
RRDWGEHARR LEDDRAWQGT ADGGMMERDQ QRWQGGERSM SGHSGPGHMM NRGGMSGRGS 900
FAPGGASRRH VIPRGGMQAG FGGTEPGQQT Q 932
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0694--RNA-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR003034--SAP_dom
PROSITE

PS50102--RRM
PS50800--SAP
Pfam

PF00076--RRM_1
PF02037--SAP
Gene Ontology

GO:0005634--C:nucleus
GO:0000166--F:nucleotide binding
GO:0019901--F:protein kinase binding
GO:0003723--F:RNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0050684--P:regulation of mRNA processing
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated