| Tag |
Content |
| dbPAF ID |
dbPAF-0003041 |
| Uniprot Accession |
O88450; DEAF1_RAT; Q62998;
|
| Genbank Protein ID |
|
| Genbank Nucleotide ID |
|
| Protein Name |
Deformed epidermal autoregulatory factor 1 homolog |
| Protein Synonyms/Alias |
Nuclear DEAF-1-related transcriptional regulator;NUDR;Suppressin; |
| Gene Name |
Deaf1 |
| Gene Synonyms/Alias |
Spn; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Transcriptional activator of EIF4G3. May also involved in behavior (By similarity).Functional Description
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Transcriptional activator of EIF4G3. May also involved in behavior (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MEDSDSAAKQ LGLAEAAAVA AAAAVAAAAA AAAESEAEEP VLSRDEDSEE DADSEAERET 60
RRVTAVAVMA AESGHMDMGT EALPSPDEAA AAAAFAEVTT VTVANVGSSA DNVFTTSVAN 120
AASISGHVLS GRTALQIGDS LNTEKATLIV VHTDGSIVET TGLKGPAAPL TPGPQSPPTP 180
LAPGQEKGGT KYNWDPSVYD SELPVRCRNI SGTLYKSRLG SGGRGRCIKQ GENWYSPTEF 240
EAMAGRASSK DWKRSIRYAG RPLQCLIQDG ILNPHAASCT CAACCDDMTL SGPVRLFVPY 300
KRRKKENELP TTPVKKDSPK NITLLPATAA TTFTVTPSGQ ITTSGALTFD RASTVEATAV 360
ISESPAQGDV FAGATVQEAG VQPPCRVGHP EPHYPGYQDS CQIAPFPEAA LPTSHPKIVL 420
TSLPALAVPP STPTKAVSPT VVSGLEMSEH RSWLYLEEMV NSLLNTAQQL KTLFEQAKQA 480
SSCREAAVTQ ARMQVDAERK EQSCVNCGRE AMSECTGCHK VNYCSTFCQR KDWKDHQHVC 540
GQSASVTVQA DDVHVEESVI EKVAV
566Fasta Sequence
>O88450|Deaf1|Rattus norvegicus(Rat)
MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAESEAEEPVLSRDEDSEEDADSEAERETRRVTAVAVMAAESGHMDMGTEALPSPDEAAAAAAFAEVTTVTVANVGSSADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEAGVQPPCRVGHPEPHYPGYQDSCQIAPFPEAALPTSHPKIVLTSLPALAVPPSTPTKAVSPTVVSGLEMSEHRSWLYLEEMVNSLLNTAQQLKTLFEQAKQASSCREAAVTQARMQVDAERKEQSCVNCGREAMSECTGCHKVNYCSTFCQRKDWKDHQHVCGQSASVTVQADDVHVEESVIEKVAV
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0964--Secreted
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR024119--TF_DEAF-1
IPR002893--Znf_MYND
|
| PROSITE |
PS50864--SAND
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2
|
| Pfam |
PF01342--SAND
PF01753--zf-MYND
|
| Gene Ontology |
GO:0005576--C:extracellular region
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0048706--P:embryonic skeletal system development
GO:0001843--P:neural tube closure
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0033599--P:regulation of mammary gland epithelial cell proliferation
GO:2000026--P:regulation of multicellular organismal development
GO:0006351--P:transcription, DNA-templated
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