dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003017
Uniprot Accession O88339; EPN1_RAT;
Genbank Protein ID NP_476477.1;
Genbank Nucleotide ID NM_057136.1;
Protein Name Epsin-1
Protein Synonyms/Alias EPS-15-interacting protein 1;
Gene Name Epn1
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
18KNIVHNYSEAEIKVRcurated23984901
411SDFDRLRTALPTSGScurated24945867
415RLRTALPTSGSSTGEcurated23984901
416LRTALPTSGSSTGELPhosphoSitePlus;curated22135298; 24945867
418TALPTSGSSTGELELPhosphoSitePlus;curated22135298; 23712012; 21630457
419ALPTSGSSTGELELLPhosphoSitePlus;curated22135298; 21630457
420LPTSGSSTGELELLAPhosphoSitePlus;curated22135298; 25532521
453SLAESVGSPPPAATPPhosphoSitePlus;UniProt22135298; 22673903
469PTPPTRKTPESFLGPPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521; 22817900; 22276854
493LVSRPGPTPPGAKAScurated23984901
535TLNQLRLSPVPPVPGPhosphoSitePlus22135298
Sequence
(Fasta)		MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI 60
WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG 120
VNVREKAKQL VALLRDEDRL REERAHALKT KEKLAQTATA SSAAVGSGPP PEAEQAWPQS 180
SGEEELQLQL ALAMSKEEAD QPPSCGPEDD VQLQLALSLS REEHDKEERI RRGDDLRLQM 240
AIEESKRETG GKEESSLMDL ADVFTTPAPP QASDPWGGPA SVPTAVPVAA AASDPWGAPA 300
VPPAADPWGG AAPTPASGDP WRPAAPTGPS VDPWGGTPAP AAGEGPTSDP WGSADGGAPV 360
SGPPSSDPWA PAPAFSDPWG GSPAKPSSNG TAVGGFDTEP DEFSDFDRLR TALPTSGSST 420
GELELLAGEV PARSPGAFDM SGVGGSLAES VGSPPPAATP TPTPPTRKTP ESFLGPNAAL 480
VDLDSLVSRP GPTPPGAKAS NPFLPSGAPA TGPSVTNPFQ PAPPATLTLN QLRLSPVPPV 540
PGAPPTYISP LGGGPGLPPM MPPGPPAPNT NPFLL 576
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR013809--ENTH
IPR008942--ENTH_VHS
IPR003903--UIM_dom
PROSITE

PS50942--ENTH
PS50330--UIM
Pfam

PF01417--ENTH
PF02809--UIM
Gene Ontology

GO:0005905--C:coated pit
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043195--C:terminal bouton
GO:0044325--F:ion channel binding
GO:0008289--F:lipid binding
GO:0008134--F:transcription factor binding
GO:0048568--P:embryonic organ development
GO:0006897--P:endocytosis
GO:0007565--P:female pregnancy
GO:0001701--P:in utero embryonic development
GO:0007219--P:Notch signaling pathway