| Tag |
Content |
| dbPAF ID |
dbPAF-0003005 |
| Uniprot Accession |
O88279; SLIT1_RAT; Q8CJG8; Q8CJG9; Q8CJH0; Q9QWL1; Q9WUG5;
|
| Genbank Protein ID |
NP_075242.1;
|
| Genbank Nucleotide ID |
NM_022953.2;
|
| Protein Name |
Slit homolog 1 protein |
| Protein Synonyms/Alias |
|
| Gene Name |
Slit1 |
| Gene Synonyms/Alias |
Megf4; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb (By similarity).Functional Description
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 522 | HKCRCEASVVECSGL | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MALTPQRGSS SGLSRPELWL LLWAAAWRLG ATACPALCTC TGTTVDCHGT GLQAIPKNIP 60
RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV ERGAFDDMKE LERLRLNRNQ 120
LQVLPELLFQ NNQALSRLDL SENSLQAVPR KAFRGATDLK NLQLDKNQIS CIEEGAFRAL 180
RGLEVLTLNN NNITTIPVSS FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT 240
QCSGPASLRG LNVAEVQKSE FSCSGQGEAA QVPACTLSSG SCPAMCSCSN GIVDCRGKGL 300
TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP DAFQGLRSLN 360
SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA FQDLQNLSLL SLYDNKIQSL 420
AKGTFTSLRA IQTLHLAQNP FICDCNLKWL ADFLRTNPIE TTGARCASPR RLANKRIGQI 480
KSKKFRCSAK EQYFIPGTED YHLNSECTSD VACPHKCRCE ASVVECSGLK LSKIPERIPQ 540
STTELRLNNN EISILEATGL FKKLSHLKKI NLSNNKVSEI EDGTFEGATS VSELHLTANQ 600
LESVRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNHIT TISPGAFDTL 660
QALSTLNLLA NPFNCNCQLA WLGDWLRKRK IVTGNPRCQN PDFLRQIPLQ DVAFPDFRCE 720
EGQEEVGCLP RPQCPQECAC LDTVVRCSNK HLQALPKGIP KNVTELYLDG NQFTLVPGQL 780
STFKYLQLVD LSNNKISSLS NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH 840
GNDVSTLQEG IFADVTSLSH LAIGANPLYC DCHLRWLSSW VKTGYKEPGI ARCAGPPEME 900
GKLLLTTPAK KFECQGPPSL AVQAKCDPCL SSPCQNQGTC HNDPLEVYRC TCPSGYKGRN 960
CEVSLDSCSS NPCGNGGTCH AQEGEDAGFT CSCPSGFEGL TCGMNTDDCV KHDCVNGGVC 1020
VDGIGNYTCQ CPLQYTGRAC EQLVDFCSPD LNPCQHEAQC VGTPEGPRCE CVPGYTGDNC 1080
SKNQDDCKDH QCQNGAQCVD EINSYACLCA EGYSGQLCEI PPAPRNSCEG TECQNGANCV 1140
DQGSRPVCQC LPGFGGPECE KLLSVNFVDR DTYLQFTDLQ NWPRANITLQ VSTAEDNGIL 1200
LYNGDNDHIA VELYQGHVRV SYDPGSYPSS AIYSAETIND GQFHTVELVT FDQMVNLSID 1260
GGSPMTMDNF GKHYTLNSEA PLYVGGMPVD VNSAAFRLWQ ILNGTSFHGC IRNLYINNEL 1320
QDFTKTQMKP GVVPGCEPCR KLYCLHGICQ PNATPGPVCH CEAGWGGLHC DQPVDGPCHG 1380
HKCVHGKCVP LDALAYSCQC QDGYSGALCN QVGAVAEPCG GLQCLHGHCQ ASATRGAHCV 1440
CSPGFSGELC EQESECRGDP VRDFHRVQRG YAICQTTRPL SWVECRGACP GQGCCQGLRL 1500
KRRKLTFECS DGTSFAEEVE KPTKCGCAPC A
1532Fasta Sequence
>O88279|Slit1|Rattus norvegicus(Rat)
MALTPQRGSSSGLSRPELWLLLWAAAWRLGATACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENSLQAVPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAAQVPACTLSSGSCPAMCSCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVECSGLKLSKIPERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLESVRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQCPQECACLDTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDVSTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPPEMEGKLLLTTPAKKFECQGPPSLAVQAKCDPCLSSPCQNQGTCHNDPLEVYRCTCPSGYKGRNCEVSLDSCSSNPCGNGGTCHAQEGEDAGFTCSCPSGFEGLTCGMNTDDCVKHDCVNGGVCVDGIGNYTCQCPLQYTGRACEQLVDFCSPDLNPCQHEAQCVGTPEGPRCECVPGYTGDNCSKNQDDCKDHQCQNGAQCVDEINSYACLCAEGYSGQLCEIPPAPRNSCEGTECQNGANCVDQGSRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTSFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPVDGPCHGHKCVHGKCVPLDALAYSCQCQDGYSGALCNQVGAVAEPCGGLQCLHGHCQASATRGAHCVCSPGFSGELCEQESECRGDPVRDFHRVQRGYAICQTTRPLSWVECRGACPGQGCCQGLRLKRRKLTFECSDGTSFAEEVEKPTKCGCAPCA
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0433--Leucine-rich repeat
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR013320--ConA-like_dom
IPR000483--Cys-rich_flank_reg_C
IPR006207--Cys_knot_C
IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR000152--EGF-type_Asp/Asn_hydroxyl_site
IPR018097--EGF_Ca-bd_CS
IPR003645--Fol_N
IPR009030--Growth_fac_rcpt_N_dom
IPR001791--Laminin_G
IPR001611--Leu-rich_rpt
IPR003591--Leu-rich_rpt_typical-subtyp
IPR000372--LRRNT
|
| PROSITE |
PS01185--CTCK_1
PS01225--CTCK_2
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01187--EGF_CA
PS50025--LAM_G_DOMAIN
PS51450--LRR
|
| Pfam |
PF00008--EGF
PF12661--hEGF
PF02210--Laminin_G_2
PF13855--LRR_8
PF01463--LRRCT
PF01462--LRRNT
|
| Gene Ontology |
GO:0005615--C:extracellular space
GO:0005578--C:proteinaceous extracellular matrix
GO:0005509--F:calcium ion binding
GO:0043395--F:heparan sulfate proteoglycan binding
GO:0008201--F:heparin binding
GO:0048495--F:Roundabout binding
GO:0007420--P:brain development
GO:0048843--P:negative regulation of axon extension involved in axon guidance
GO:0051964--P:negative regulation of synapse assembly
GO:0035385--P:Roundabout signaling pathway
GO:0021510--P:spinal cord development
|
