dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0003004
Uniprot Accession O88278; CELR3_RAT;
Genbank Protein ID NP_112610.1;
Genbank Nucleotide ID NM_031320.1;
Protein Name Cadherin EGF LAG seven-pass G-type receptor 3
Protein Synonyms/Alias Multiple epidermal growth factor-like domains protein 2;Multiple EGF-like domains protein 2;
Gene Name Celsr3
Gene Synonyms/Alias Megf2;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Receptor that may have an important role in cell/cell signaling during nervous system formation.
Phosphorylation Sites
dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
2109DSPFAEVTASGCRVLdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
2111PFAEVTASGCRVLYDdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
2117ASGCRVLYDACPKSLdbPTM 3.0;PhosphoSitePlus;UniProt16641100; 16381945; 23193290; 22135298
3045HRAVPAASYGRIYAGdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
3046RAVPAASYGRIYAGGdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
3050AASYGRIYAGGGTGSdbPTM 3.0;PhosphoSitePlus;UniProt16641100; 16381945; 23193290; 22135298
3098APVLHPLSRPGSQERdbPTM 3.0;PhosphoSitePlus;UniProt16641100; 16381945; 23193290; 22135298
Sequence
(Fasta)
MARRPLWWGL PGPSTPLLLL LLFSLFPSSR EEMGGGGDQG WDPGVATATG PRAQIGSGAV 60
ALCPESPGVW EDGDPGLGVR EPVFMKLRVG RQNARNGRGA PEQPNREPVV QALGSREQEA 120
GQGSGYLLCW HPEISSCGRT GHLRRGSLPL DALSPGDSDL RNSSPHPSEL LAQPDSPRPV 180
AFQRNGRRSI RKRVETFRCC GKLWEPGHKG QGERSATSTV DRGPLRRDCL PGSLGSGLGE 240
DSAPRAVRTA PAPGSAPHES RTAPERMRSR GLFRRGFLFE RPGPRPPGFP TGAEAKRILS 300
TNQARSRRAA NRHPQFPQYN YQTLVPENEA AGTAVLRVVA QDPDPGEAGR LVYSLAALMN 360
SRSLELFSID PQSGLIRTAA ALDRESMERH YLRVTAQDHG SPRLSATTMV AVTVADRNDH 420
APVFEQAQYR ETLRENVEEG YPILQLRATD GDAPPNANLR YRFVGSPAAR TAAAAAFEID 480
PRSGLISTSG RVDREHMESY ELVVEASDQG QEPGPRSATV RVHITVLDEN DNAPQFSEKR 540
YVAQVREDVR PHTVVLRVTA TDKDKDANGL VHYNIISGNS RGHFAIDSLT GEIQVMAPLD 600
FEAEREYALR IRAQDAGRPP LSNNTGLASI QVVDINDHSP IFVSTPFQVS VLENAPLGHS 660
VIHIQAVDAD HGENSRLEYS LTGVASDTPF VINSATGWVS VSGPLDRESV EHYFFGVEAR 720
DHGSPPLSAS ASVTVTVLDV NDNRPEFTMK EYHLRLNEDA AVGTSVVSVT AVDRDANSAI 780
SYQITGGNTR NRFAISTQGG MGLVTLALPL DYKQERYFKL VLTASDRALH DHCYVHINIT 840
DANTHRPVFQ SAHYSVSMNE DRPVGSTVVV ISASDDDVGE NARITYLLED NLPQFRIDAD 900
SGAITLQAPL DYEDQVTYTL AITARDNGIP QKADTTYVEV MVNDVNDNAP QFVASHYTGL 960
VSEDAPPFTS VLQISATDRD AHANGRVQYT FQNGEDGDGD FTIEPTSGIV RTVRRLDREA 1020
VPVYELTAYA VDRGVPPLRT PVSIQVTVQD VNDNAPVFPA EEFEVRVKEN SIVGSVVAQI 1080
TAVDPDDGPN AHIMYQIVEG NIPELFQMDI FSGELTALID LDYEARQEYV IVVQATSAPL 1140
VSRATVHVRL VDQNDNSPVL NNFQILFNNY VSNRSDTFPS GIIGRIPAYD PDVSDHLFYS 1200
FERGNELQLL VVNQTSGELR LSRKLDNNRP LVASMLVTVT DGLHSVTAQC VLRVVIITEE 1260
LLANSLTVRL ENMWQERFLS PLLGHFLEGV AAVLATPTED VFIFNIQNDT DVGGTVLNVS 1320
FSALAPRGAG AGAAGPWFSS EELQEQLYVR RAALAARSLL DVLPFDDNVC LREPCENYMK 1380
CVSVLRFDSS APFLASASTL FRPIQPIAGL RCRCPPGFTG DFCETELDLC YSNPCRNGGA 1440
CARREGGYTC VCRPRFTGED CELDTEAGRC VPGVCRNGGT CTNAPNGGFR CQCPAGGAFE 1500
GPRCEVAARS FPPSSFVMFR GLRQRFHLTL SLSFATVQPS GLLFYNGRLN EKHDFLALEL 1560
VAGQVRLTYS TGESSTVVSP TVPGGLSDGQ WHTVHLRYYN KPRTDALGGA QGPSKDKVAV 1620
LSVDDCNVAV ALRFGAEIGN YSCAAAGVQT SSKKSLDLTG PLLLGGVPNL PENFPVSRKD 1680
FIGCMRDLHI DGRRVDMAAF VANNGTTAGC QAKSHFCASG PCKNGGLCSE RWGGFSCDCP 1740
VGFGGKDCRL TMAHPYHFQG NGTLSWDFGN DMPVSVPWYL GLSFRTRATK GVLMQVQLGP 1800
HSVLLCKLDQ GLLSVTLSRA SGHAVHLLLD QMTVSDGRWH DLRLELQEEP GGRRGHHIFM 1860
VSLDFTLFQD TMAMGSELEG LKVKHLHVGG PPPSSKEEGP QGLVGCIQGV WTGFTPFGSS 1920
ALPPPSHRIN VEPGCTVTNP CASGPCPPHA NCKDLWQTFS CTCWPGYYGP GCVDACLLNP 1980
CQNQGSCRHL QGGPHGYTCD CASGYFGQHC EHRMDQQCPR GWWGSPTCGP CNCDVHKGFD 2040
PNCNKTSGQC HCKEFHYRPR GSDSCLPCDC YPVGSTSRSC APHSGQCPCR PGALGRQCNS 2100
CDSPFAEVTA SGCRVLYDAC PKSLRSGVWW PQTKFGVLAT VPCPRGALGL RGTGAAVRLC 2160
DEDHGWLEPD FFNCTSPAFR ELSLLLDGLE LNKTALDTVE AKKLAQRLRE VTGQTDHYFS 2220
QDVRVTARLL AYLLAFESHQ QGFGLTATQD AHFNENLLWA GSALLAPETG DLWAALGQRA 2280
PGGSPGSAGL VRHLEEYAAT LARNMDLTYL NPVGLVTPNI MLSIDRMEQP SSSQGAHRYP 2340
RYHSNLFRGQ DAWDPHTHVL LPSQSPQPSP SEVLPTSSNA ENATASGVVS PPAPLEPESE 2400
PGISIVILLV YRALGGLLPA QFQAERRGAR LPQNPVMNSP VVSVAVFRGR NFLRGALVSP 2460
INLEFRLLQT ANRSKAICVQ WDPPGPADQH GMWTARDCEL VHRNGSHARC RCSRTGTFGV 2520
LMDASPRERL EGDLELLAVF THVVVAASVT ALVLTAAVLL SLRSLKSNVR GIHANVAAAL 2580
GVAELLFLLG IHRTHNQLLC TVVAILLHYF FLSTFAWLLV QGLHLYRMQV EPRNVDRGAM 2640
RFYHALGWGV PAVLLGLAVG LDPEGYGNPD FCWISIHEPL IWSFAGPIVL VIVMNGIMFL 2700
LAARTSCSTG QREAKKTSVL RTLRSSFLLL LLVSASWLFG LLAVNHSVLA FHYLHAGLCG 2760
LQGLAVLLLF CVLNADARAA WTPACLGKKA APEETRPAPG PGSGAYNNTA LFEESGLIRI 2820
TLGASTVSSV SSARSGRAQD QDSQRGRSYL RDNVLVRHGS TAEHAEHSLQ AHAGPTDLDV 2880
AMFHRDAGAD SDSDSDLSLE EERSLSIPSS ESEDNGRTRG RFQRPLRRAA QSERLLAHPK 2940
DVDGNDLLSY WPALGECEAA PCALQAWGSE RRLGLDSNKD AANNNQPELA LTSGDETSLG 3000
RAQRQRKGIL KNRLQYPLVP QTRGTPELSW CRAATLGHRA VPAASYGRIY AGGGTGSLSQ 3060
PASRYSSREQ LDLLLRRQLS RERLEEVPVP APVLHPLSRP GSQERLDTAP ARLEPRDRGS 3120
TLPRRQPPRD YPGTMAGRFG SRDALDLGAP REWLSTLPPP RRNRDLDPQH PPLPLSPQRP 3180
LSRDPLLPSR PLDSLSRISN SRERLDQVPS RHPSREALGP APQLLRARED PASGPSHGPS 3240
TEQLDILSSI LASFNSSALS SVQSSSTPSG PHTTATPSAT ASALGPSTPR SATSHSISEL 3300
SPDSEVPRSE GHS 3314
Keyword

KW-0106--Calcium
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0379--Hydroxylation
KW-0424--Laminin EGF-like domain
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002126--Cadherin
IPR015919--Cadherin-like
IPR020894--Cadherin_CS
IPR013320--ConA-like_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR032471--GAIN_dom_N
IPR017981--GPCR_2-like
IPR001879--GPCR_2_extracellular_dom
IPR000832--GPCR_2_secretin-like
IPR017983--GPCR_2_secretin-like_CS
IPR000203--GPS
IPR002049--Laminin_EGF
IPR001791--Laminin_G

PROSITE

PS00010--ASX_HYDROXYL
PS00232--CADHERIN_1
PS50268--CADHERIN_2
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01248--EGF_LAM_1
PS50027--EGF_LAM_2
PS00650--G_PROTEIN_RECEP_F2_2
PS50227--G_PROTEIN_RECEP_F2_3
PS50261--G_PROTEIN_RECEP_F2_4
PS50221--GPS
PS50025--LAM_G_DOMAIN

Pfam

PF00002--7tm_2
PF00028--Cadherin
PF00008--EGF
PF16489--GAIN
PF02793--HRM
PF00053--Laminin_EGF
PF02210--Laminin_G_2

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0004930--F:G-protein coupled receptor activity
GO:0007413--P:axonal fasciculation
GO:0007166--P:cell surface receptor signaling pathway
GO:0042384--P:cilium assembly
GO:0007156--P:homophilic cell adhesion via plasma membrane adhesion molecules
GO:0001764--P:neuron migration
GO:0032880--P:regulation of protein localization
GO:0001932--P:regulation of protein phosphorylation