dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0003003
Uniprot Accession O88277; FAT2_RAT;
Genbank Protein ID NP_075243.1;
Genbank Nucleotide ID NM_022954.1;
Protein Name Protocadherin Fat 2
Protein Synonyms/Alias Multiple epidermal growth factor-like domains protein 1;Multiple EGF-like domains protein 1;
Gene Name Fat2
Gene Synonyms/Alias Fath2;Megf1;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
May modulate the extracellular space surronding parallel fibers of cerebellar during development. Plays a role in the migration of epidermal cells (By similarity).
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
1701LREGNKDSVFSMNSYdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
2910DNPPRFASEDYRGSVdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
Sequence
(Fasta)
MTLVLLGLAI LLLHRAACEK SLEETIPPLS WRFTHSLYNA TIYENSAPKT YVESPVKMGM 60
YLAEPHWVVK YRIISGDAAG VFKTEEHVVG NFCFLRIRTK SSNTALLNRE VRDSYTLIVQ 120
ASDKSLEFEA LTQVVVHILD QNDLKPLFSP PSYRVTISED RPLKSPICKV TATDADLGQN 180
AEFYYAFNAR SEVFAIHPTS GVVTVAGKLN VTRRGKYELQ VLAVDRMRKI SEGNGFGNLA 240
SLVIRVEPVH RKPPAINLVV LNPPEGDEGD IYAIVTVDTN GSGAEVDSLE VVGGDPGKYF 300
KVLRSYAQGN EFNLVAVRDI NWAEHPHGFN ISLQTHSWSR FPPHSIIRAF HLPSWKLANL 360
RFEKAVYRVK LSEFSPPGSR VALVKVTTAL PNLRYSLKPS SRNTAFKLNA RTGLITTTKL 420
VDFHEQNQYQ LHVKTSLGQA TTTVIIDIVD CNNHAPVFNR SSYEGTLDEN IPPGTSVLTV 480
TATDQDHGDN GHITYSIAGP KAVPFSIDPL LGVISTTKPM DYELMKRIYT FRVRASDWGS 540
PFRQEKEVSV SLRLKNLNDN QPMFEEVNCT VSLRQDVPVG KSIMAVSAID MDELQNLKYE 600
IVSGNEQDYF HLNHFSGVIS LKRSFMNLTA VRPTIYSLKI TASDGKNYAS PTTLKVTVVK 660
DPHSEVPVQC DKTGVLTHIT KTILQSAGLQ SQELGEEEFT SLSNYQINHH SPQFEDHFPQ 720
SIDILEQVPI NTPLARLAAT DPDTGFHGKL VYVISDGNEE GCFDIELETG LLMVAAALDY 780
ETTSFYVLNV TVYDLGTPPK SSWKLLTVTV KDWNDNPPRF PPGGYQLTIS EDTEVGTTIA 840
ELKTEDADSE DNRRVRYTLL TPTEKFSLHP FTGELVVTGH LDRESESQYI LKAEARDQPT 900
KGHQLFSVTD LIVTLEDIND NPPQCITEHR RLKVPEDMPL GTVLTFLDAS DPDLGPAGEV 960
KYILVEDAHG TFQVHPMTGA LSLEKELDFE RRAGYNLSFW ASDSGKPLSR RTLCHVEVLV 1020
MDVNENLHSP HFSSFVYQGQ VQENSPAGTP VMVVTAQDDD SGLDGELQYF LRAGTGLETF 1080
SINQDTGMLE TLAPLDREFT PYYWLTVLAV DRGSVPLSAV TEVYIEVTDI NDNIPSMSRP 1140
VFYPSVLEDA PLGTSVLQLE AWDPDSSSQG KLTFNLTSGN HLGHFIVHPF TGLLTTAKQL 1200
DRENKDEYVL EVTVQDNGDP SLRSTSRVVV CILDVNDNPP MFSHKLFNVR LSERLSPLSP 1260
EPVYRLVASD PDEGLNGSVT YSIEESDEES FRIDPVTGVV SSSSTFAAGE YNILTIKATD 1320
SGQPALSTSV RLHIEWIPQP RPSSIPLSFD ESYYSFTVME TDPVNHMVGV ISVEGRPGLF 1380
WFHISDGDKD MDFDIEKTTG SIVIARPLDT RRKSSYNLTV EVTDGFHTIA TQVHIFMIAN 1440
INHHRPQFLQ DHYEIRVPQD TLPGVELLRV QATDQDHGKG LIYTILSSQD PGSANLFQLD 1500
PSSGVLVTVG TLELHSGPSQ HILTVMVRDQ EMPIKRNFVW VTIHVEDGNL HSPHFTQLRY 1560
EANVPDTTAP GTELLQVRAV DADRGANAEI HYSFLKGNSD GFFNIDSLLG IITVAQRLYH 1620
VHLTRHALTV KAEDQGSPRR HDLALVVIHV HPSDSSAPVF SKDEYFIEIP ESVPIGSPIL 1680
LLSAGSSSEV TYELREGNKD SVFSMNSYSG LISTQKRLDH EKVPSYRLRI RGSNMAGVFT 1740
EVVALVYIID ENDNPPAFGK PTFLGHISEA APLHSLILGE DNSPLVVRAS DSDREANSLL 1800
VYKILEPEAL KFFKIDPSMG TLTTTSELDF EDTPLFQFNI YVHDQGTPIL FAPRSAKVII 1860
HVRDVNDSPP RFSEQIYEVA VVEPIHPGMG LLTVQAEDND SRVTYSIKTS NADEAVTIHP 1920
TTGQISVVNP ATLRLFQKFS IRASDGLYHD TAVVKISLTQ VLDKSLQFDQ DVYRARVTEN 1980
TPHRKALVIL GVHGNHLNDT LSYFLLNGTD LFHMIESAGV LQTRGGTFDR EQQDTHEVAV 2040
EVRDNRVPQR VAQALVRVSV EDVNDNIPEF QHLPYYTVIQ DGTEPGDVLF QVSATDKDLG 2100
ANGSVTYGFA EDYAYFRIDP YVGDISLKKP FDYQALNKYH LRVIARDSGI PPLQTEVEVH 2160
VTVRNKSNPL FQSPYYKVKV PENITLYTPI LHTQARSPEG LRLIYNIVEE EPLMLFTTDF 2220
KTGVLTVTGP LDYESKNKHV FTVRATDTAL GSFSEATVEV LVEDINDNPP TFSQLVYTTS 2280
VSEGSPAQTP VIQLLASDQD SGQNQDVSYQ IVEDGSDVSK FFRINGSTGE IFTIQELDYE 2340
THQHFRVKVR AMDKGDPPLT GETLVVVNVS DINDNPPKFR EPQYEANVSE LATCGHLVLK 2400
VQALDPDIGD TSRLEYLILS GNQDRHFSIN STSGIISMFN LCKKQLDSSY NLRVGASDGV 2460
FRATVPVYIN TTNANKYSPE FQQNVYEAEL AENAKVGTKV IELLAIDKDS GPYGTVDYTI 2520
INKLAGERFF INPRGQITTL QKLDRENSTE RVIAIKVMAR DGGGKVAFCT VKIILTDEND 2580
NAPQFKASGY TVSIPSNVSR DSPIIQVLAY DADEGRNADV TYSVDSTEDL AEEIIEVNPT 2640
TGVVKVKESL VGLENRAVDF NIKAQDGGPP HWDSLVPVRL QVVPNEIPLP KFSEPLYTFS 2700
APEDLPEGSE IGSVKAVAAQ DPIIYSLVQG TTPESNSDDV FSLDQDTGVL KVRKAMDHES 2760
TKWYQIDLMA HCPHEDTDLV SLVSVSIQVE DVNDNRPVFE ADPYKAFLTE NMPGGTTVIQ 2820
VTANDQDTGS DGQVSYRLSV EPGSNIHELF AVDSESGWIT TLQELDCETQ QTYRFYVVAF 2880
DHGQTIQLSS QALVEVSITD ENDNPPRFAS EDYRGSVVEN NEPGELVATL KTLDADVSDQ 2940
NRQVTCYITE GDPLGQFSIS QVGDEWRISS RKTLDREHIA KYLLRVTASD GKFQASVPVE 3000
VFVVDINDNS PQCSQLLYTG KVREDVTPGH FILKVSAIDV DMDTNAQITY SLHGPGAQEF 3060
KLDPHTGELT TLTVLDRERK DVYNLVAKAT DGGGQSCQAE VTLHIEDVND NAPRFFPSHC 3120
DVAVFDNTTV KTPVAVVFAR DPDQGANAQV VYSLTDSADG QFSIDATSGV IRLEKPLQVR 3180
ASSAVELTVR ASDLGTPIPL STLGTVTVSV VGLEDYLPIF LNAEHSTQVP EDAPIDMEVL 3240
HLATLTRPGS EKTGYHITGG NEQGKFRLDA HTGILYVNGS LDFETNPKYF LSIECSRKSS 3300
SSLSDVTTIV INVTDVNEHH PRFTHDLYTV RVLENAVVGD VILTVSASDD DGPVNSAITY 3360
SLVGGNQLGH FTINPKKGKL QVAKALDWEQ TPSYSLRLRA TDSGQPPLHE DTEVAVEVVD 3420
VNDNPPRFFQ LNYSTSVQEN SPIGIKVLQL ILDDPDSPQN GPPYFFRITE GNTGSVFRVT 3480
PDGWLVTAAS LSKKAREWYQ LHIEVSDSGL PPLSSSTLVR VQVTEQSRYP PSTLPLEISI 3540
TKGEEEFQGG MIGKIHATDR DPQDTLTYSL EQEGGLDRYF TVGASDGKII ASQGLPHGRY 3600
SFNVTVSDGT FTTTTGVHVH VWHMEPEVPQ QAVWLGFHQL TPEELVSDHW RNLQRFLSNL 3660
LDVKRANIHL ASLQPAEVTA GVDVLLVFER HSGTSYDLQE LASAIAHSVR EIEHSVGIRM 3720
RSALPVVPCQ GQSCQDQTCQ ETVSLEPRVG PSYSTARLSI LTPRHHLGRN CSCNGTTLRF 3780
SGQSYVQYRP LEAQNWQIHF YLKTLQPWAL LMFTNETASI SLKLANGFSH LEYHCPGGFY 3840
GNLSSRYPVN DGQWHSMLLE ERDTSVHLLV DITDNASLVI PEECQGLRTE RQLLLGGLVP 3900
SNPSSNVSLG FEGCLDAVVV NGERLELLGR EKKMEGRLET WALSQCCWPG TACSQSPCLN 3960
GGSCSPALGS GYLCRCPPPF SGRNCELGRE NCTSAPCQEG GTCVSSPEGT SCNCPHPYTG 4020
DRCEMEARGC SGGHCLITPE IKRGDWGQQE FLVITVALPL VIIATVGLLL YCRRRKSHKP 4080
VTMEDPDLLA RSIGVDTQAS PAIELDPLNT SSCNNLNQPE PSKTSVPNEL VTFGPSSKQR 4140
PMVCSVPPRL PPAAVSSHPG HEPIIKRTWS GEELVYPSGA AVWPPTYSRK KHWEYPHPET 4200
MQGTLPPSPR RHVGPAVMPD PTGLYGGFPF PLELENKRAP LPPRYSNQNL EDLMPPRPPS 4260
PREHLLAPCL NEYTAISYYH SQFRQGGGGP CLAEGGYKGV SMRLSRAGPS YADCEVNGGP 4320
ATGRSQPRAP PNYEGSDMVE SDYGSCEEVM F 4352
Keyword

KW-0106--Calcium
KW-0130--Cell adhesion
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002126--Cadherin
IPR015919--Cadherin-like
IPR020894--Cadherin_CS
IPR013320--ConA-like_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR001791--Laminin_G

PROSITE

PS00232--CADHERIN_1
PS50268--CADHERIN_2
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS50025--LAM_G_DOMAIN

Pfam

PF00028--Cadherin
PF00008--EGF
PF02210--Laminin_G_2

Gene Ontology

GO:0005913--C:cell-cell adherens junction
GO:0016021--C:integral component of membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0010631--P:epithelial cell migration
GO:0007156--P:homophilic cell adhesion via plasma membrane adhesion molecules