| Tag |
Content |
| dbPAF ID |
dbPAF-0003002 |
| Uniprot Accession |
O88275; PPARG_RAT; Q9QWG0; Q9R197;
|
| Genbank Protein ID |
NP_001138838.1; NP_001138839.1; NP_037256.1; XP_006237071.1;
|
| Genbank Nucleotide ID |
NM_001145366.1; NM_001145367.1; NM_013124.3; XM_006237009.2;
|
| Protein Name |
Peroxisome proliferator-activated receptor gamma |
| Protein Synonyms/Alias |
|
| Gene Name |
Pparg |
| Gene Synonyms/Alias |
Nr1c3; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.Functional Description
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MGETLGDPPV DPEHGAFADA LPMSTSQEIT MVDTEMPFWP TNFGISSVDL SVMDDHSHSF 60
DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT 120
QLYNRPHEEP SNSLMAIECR VCGDKASGFH YGVHACEGCK GFFRRTIRLK LIYDRCDLNC 180
RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR 240
ALAKHLYDSY IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE 300
QSKEVAIRIF QGCQFRSVEA VQEITEYAKN IPGFINLDLN DQVTLLKYGV HEIIYTMLAS 360
LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV KFNALELDDS DLAIFIAVII 420
LSGDRPGLLN VKPIEDIQDN LLQALELQLK LNHPESSQLF AKVLQKMTDL RQIVTEHVQL 480
LHVIKKTETD MSLHPLLQEI YKDLY
506Fasta Sequence
>O88275|Pparg|Rattus norvegicus(Rat)
MGETLGDPPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMDDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
|
| Keyword |
KW-0010--Activator
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0325--Glycoprotein
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR003074--1Cnucl_rcpt
IPR003077--1Cnucl_rcpt_G
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR022590--PPARgamma_N
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA
|
| PROSITE |
PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2
|
| Pfam |
PF00104--Hormone_recep
PF12577--PPARgamma_N
PF00105--zf-C4
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0003677--F:DNA binding
GO:0008144--F:drug binding
GO:0030331--F:estrogen receptor binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0019903--F:protein phosphatase binding
GO:0001012--F:RNA polymerase II regulatory region DNA binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050873--P:brown fat cell differentiation
GO:0048469--P:cell maturation
GO:0071455--P:cellular response to hyperoxia
GO:0032869--P:cellular response to insulin stimulus
GO:0071285--P:cellular response to lithium ion
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0071379--P:cellular response to prostaglandin stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071306--P:cellular response to vitamin E
GO:0002024--P:diet induced thermogenesis
GO:0030855--P:epithelial cell differentiation
GO:0006631--P:fatty acid metabolic process
GO:0019395--P:fatty acid oxidation
GO:0042593--P:glucose homeostasis
GO:0007507--P:heart development
GO:0042953--P:lipoprotein transport
GO:0015909--P:long-chain fatty acid transport
GO:0045713--P:low-density lipoprotein particle receptor biosynthetic process
GO:0030224--P:monocyte differentiation
GO:0002674--P:negative regulation of acute inflammatory response
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0010887--P:negative regulation of cholesterol storage
GO:0032966--P:negative regulation of collagen biosynthetic process
GO:0060336--P:negative regulation of interferon-gamma-mediated signaling pathway
GO:2000230--P:negative regulation of pancreatic stellate cell proliferation
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0051974--P:negative regulation of telomerase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0031100--P:organ regeneration
GO:0035357--P:peroxisome proliferator activated receptor signaling pathway
GO:0001890--P:placenta development
GO:0043065--P:positive regulation of apoptotic process
GO:0045600--P:positive regulation of fat cell differentiation
GO:0046321--P:positive regulation of fatty acid oxidation
GO:0048714--P:positive regulation of oligodendrocyte differentiation
GO:0060100--P:positive regulation of phagocytosis, engulfment
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0008217--P:regulation of blood pressure
GO:0042752--P:regulation of circadian rhythm
GO:0045598--P:regulation of fat cell differentiation
GO:0019216--P:regulation of lipid metabolic process
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0060850--P:regulation of transcription involved in cell fate commitment
GO:0031000--P:response to caffeine
GO:0009409--P:response to cold
GO:0036270--P:response to diuretic
GO:0042493--P:response to drug
GO:0043627--P:response to estrogen
GO:0035902--P:response to immobilization stress
GO:0033993--P:response to lipid
GO:0055098--P:response to low-density lipoprotein particle
GO:0009612--P:response to mechanical stimulus
GO:1901558--P:response to metformin
GO:0014070--P:response to organic cyclic compound
GO:0010033--P:response to organic substance
GO:0032526--P:response to retinoic acid
GO:0042594--P:response to starvation
GO:0033189--P:response to vitamin A
GO:0048511--P:rhythmic process
GO:0050872--P:white fat cell differentiation
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