dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002999
Uniprot Accession O88269; MRP6_RAT;
Genbank Protein ID NP_112275.1;
Genbank Nucleotide ID NM_031013.1;
Protein Name Multidrug resistance-associated protein 6
Protein Synonyms/Alias ATP-binding cassette sub-family C member 6;MRP-like protein 1;MLP-1;
Gene Name Abcc6
Gene Synonyms/Alias Mlp1;Mrp6;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
760GGQKQRLSLARAVYRdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
891RPERPRPSDAAPVKGPhosphoSitePlus;UniProt;curated22135298; 22673903; 23353032
Sequence
(Fasta)		MNGEHSMATP GESCAGLRVW NQTEQEPVAY HLLNLCFLRA AGSWVPPMYL WVLGPIYLLY 60
IHRHGCCYLR MSRLFKIKMV LGFALILLYT FNAAVPLWRI HRGMPQAPEL LIHPTVWLTT 120
MSFATFLIHM ERKKGVRASG LLFGYWLLCC LVPAIDTVQQ ASAGSFRQEP LHHLATYLCL 180
SLVVAELVLS CLVDQPPFFS EDSKPLNPCP EAEASFPSKA MFWWASGLLW KGYRKLLGPK 240
DLWSLERENS SEELVSQLER EWRRNFSELP GHKGHSGMGT PETEAFLQPE RSQRGPLLRA 300
IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDL ESSAWTGWLL AVLMFLSACL 360
QTLFEQQYMY RVKVLQMRLR TAITGLVYRK VLVLSSGSRK SSAAGDVVNL VSVDVQRLVE 420
SILHLNGLWL LFLWIIVCFV YLWQLLGPSA LTAVAVFLSL LPLNFFITKK RSFHQEEQMR 480
QKASRARLTS SMLRTVRTIK SHGWECAFLE RLLHIRGQEL GALKTSAFLF SVSLVSFQVS 540
TFLVALVVFA VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCL VQARVSFDRL 600
AAFLCLEEVD PNGMVLSPSR CSSKDRISIH NGTFAWSQES PPCLHGINLT VPQGCLLAVV 660
GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV QNTSVVENVC FRQELDLPWL 720
QEVLEACALG SDVASFPAGV HTPVGEQGMN LSGGQKQRLS LARAVYRRAA VYLMDDPLAA 780
LDAHVSQEVF KQVIGPSGLL QGTTRILVTH TLHVLPQADQ ILVLANGTIA EMGSYQDLLH 840
RNGALVGLLD GARQPAGEGE GEAHAAATSD DLGGFSGGGT PTRRPERPRP SDAAPVKGST 900
SEAQMEPSLD DVEVTGLTAG EDSVQYGRVK SATYLSYLRA VGTPLCTYTL FLFLCQQVAS 960
FCQGYWLSLW ADDPVVDGKQ MHSALRGSIF GLLGCLQAIG LFASMAAVFL GGARASCLLF 1020
RSLLWDVARS PIGFFERTPV GNLLNRFSKE TDIVDVDIPD KMRTLLTYAF GLLEVGLAVS 1080
MATPLAIVAI LPLMLLYAGF QSLYVATCCQ LRRLESASYS SVCSHLAETF QGSQVVRAFQ 1140
AQGPFTAQHD ALMDENQRIS FPRLVADRWL AANLELLGNG LVFVAATCAV LSKAHLSAGL 1200
AGFSVSAALQ VTQTLQWVVR SWTDLENSMV AVERVQDYVH TPKEAPWRLP SSAAQPLWPC 1260
GGQIEFRDFG LRHRPELPMA VQGVSLKIHA GEKVGIVGRT GAGKSSLTWG LLRLQEATEG 1320
GIWIDGVPIT DMGLHTLRSR ITIIPQDPVL FPGSLRMNLD LLQENTDEGI WAALETVQLK 1380
AFVTSLPGQL QYECSGQGDD LSVGQKQLLC LARALLRKTQ ILILDEATAS VDPGTEIQMQ 1440
AALERWFAQC TVLLIAHRLR SVMNCARVLV MDEGQVAESG SPAQLLAQKG LFYRLAQESG 1500
LA 1503
Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR003593--AAA+_ATPase
IPR011527--ABC1_TM_dom
IPR003439--ABC_transporter-like
IPR017871--ABC_transporter_CS
IPR030239--ABCC6
IPR005292--Multidrug-R_assoc
IPR027417--P-loop_NTPase
PROSITE

PS50929--ABC_TM1F
PS00211--ABC_TRANSPORTER_1
PS50893--ABC_TRANSPORTER_2
Pfam

PF00664--ABC_membrane
PF00005--ABC_tran
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0016021--C:integral component of membrane
GO:0016328--C:lateral plasma membrane
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0042626--F:ATPase activity, coupled to transmembrane movement of substances