dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0002994 |
| Uniprot Accession | O77460; IPYR_DROME; Q9W150; |
| Genbank Protein ID | NP_001137758.1; NP_523849.3; |
| Genbank Nucleotide ID | NM_001144286.3; NM_079125.3; |
| Protein Name | Inorganic pyrophosphatase |
| Protein Synonyms/Alias | Nucleosome-remodeling factor 38 kDa subunit;Pyrophosphate phospho-hydrolase;PPase; |
| Gene Name | Nurf-38 |
| Gene Synonyms/Alias | CG4634; |
| Organism | Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID | 7227 |
| Functional Description (View all) |
Component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. NURF is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. Nurf-38 may have adapted to deliver pyrophosphatase to chromatin to assist in replication or transcription by efficient removal of the inhibitory metabolite. |
| Phosphorylation Sites |
dbPAF PTMs: 3 |
| Sequence (Fasta) | MLAKITRSSF YASRAVGRLS GSIPTSPAAL ASNCRYIQIE RKRTKSHEMA LYETVEKGAK 60 NSPSYSLYFK NKCGNVISPM HDIPLYANEE KTIYNMVVEV PRWTNAKMEI SLKTPMNPIK 120 QDIKKGKLRF VANCFPHKGY IWNYGALPQT WENPDHIEPS TGCKGDNDPI DVIEIGYRVA 180 KRGDVLKVKV LGTIALIDEG ETDWKIIAID VNDPLASKVN DIADVDQYFP GLLRATVEWF 240 KIYKIPDGKP ENQFAFNGDA KNADFANTII AETHKFWQNL VHQSPASGSI STTNITNRNS 300 EHVIPKEEAE KILAEAPDGG QVEEVSDTVD TWHFIHLK 339 |
| Keyword | KW-0156--Chromatin regulator |
| Interpro | IPR008162--Pyrophosphatase |
| PROSITE | PS00387--PPASE |
| Pfam | PF00719--Pyrophosphatase |
| Gene Ontology | GO:0005737--C:cytoplasm |