| Tag |
Content |
| dbPAF ID |
dbPAF-0002993 |
| Uniprot Accession |
O77459; KEN_DROME;
|
| Genbank Protein ID |
NP_523833.1;
|
| Genbank Nucleotide ID |
NM_079109.3;
|
| Protein Name |
Transcription factor Ken |
| Protein Synonyms/Alias |
Protein Ken and Barbie; |
| Gene Name |
ken |
| Gene Synonyms/Alias |
CG5575; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles.Functional Description
Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MKEFQRMLML QYSKHGECIL KEIGAAFRGE HPADLTIVCE NKVKLHAHKL VLAAASPLIR 60
NLLEDTHLSD CSTTVYFPDV NATYFKFLLD FLYSGQTCIT SRDVNYLHDL LLLLQIKSDS 120
WKTTDSAYLS SKCGGLRDRA DRRKQQYTSP QNLEPDQTLK YEVDSVDESR NAADFSSAFN 180
SNDNCESAAE CERSGGHNNK EEDEDDCTHK DNKSDKDTDE IVNLSNAPPS GTSGSNSNIS 240
TSSNHQQQQH HHHHHHNHNN NNNNNNNNSS SSTINPVNLS LDLRTKSENS ASRTLGSGSD 300
HSGIDLAVTA SESTKRKGLF FDSHKDVMKP LSDGSDINSS PENYVVTPHR KRRPGFHNTQ 360
SDNQPFTSYP HSLLEELRLA KSTTSPISGF GSEKNMLAHL EDGALNGDTL TPDRKHLLEA 420
QRNRAQSPEI PMHLGPQFVY QWQSNQNAAM SAMPNLQSRL SSLSHISLNL DHPEGRSGSA 480
SGSGANLAGS NTHASSVREY RCEYCGKQFG MSWNLKTHLR VHTGEKPFAC RLCVAMFKQK 540
AHLLKHLCSV HRNVITTTNG ADTENRYSCC FCSMCFESVQ ELVRHLSGHH NNLLLTKNLR 600
E
602Fasta Sequence
>O77459|ken|Drosophila melanogaster(Fruit fly)
MKEFQRMLMLQYSKHGECILKEIGAAFRGEHPADLTIVCENKVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYLHDLLLLLQIKSDSWKTTDSAYLSSKCGGLRDRADRRKQQYTSPQNLEPDQTLKYEVDSVDESRNAADFSSAFNSNDNCESAAECERSGGHNNKEEDEDDCTHKDNKSDKDTDEIVNLSNAPPSGTSGSNSNISTSSNHQQQQHHHHHHHNHNNNNNNNNNNSSSSTINPVNLSLDLRTKSENSASRTLGSGSDHSGIDLAVTASESTKRKGLFFDSHKDVMKPLSDGSDINSSPENYVVTPHRKRRPGFHNTQSDNQPFTSYPHSLLEELRLAKSTTSPISGFGSEKNMLAHLEDGALNGDTLTPDRKHLLEAQRNRAQSPEIPMHLGPQFVYQWQSNQNAAMSAMPNLQSRLSSLSHISLNLDHPEGRSGSASGSGANLAGSNTHASSVREYRCEYCGKQFGMSWNLKTHLRVHTGEKPFACRLCVAMFKQKAHLLKHLCSVHRNVITTTNGADTENRYSCCFCSMCFESVQELVRHLSGHHNNLLLTKNLRE
|
| Keyword |
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR000210--BTB/POZ_dom
IPR011333--POZ_dom
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
|
| PROSITE |
PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
|
| Pfam |
PF00651--BTB
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0007620--P:copulation
GO:0045497--P:female analia development
GO:0030540--P:female genitalia development
GO:0007320--P:insemination
GO:0045496--P:male analia development
GO:0030539--P:male genitalia development
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006909--P:phagocytosis
GO:0046425--P:regulation of JAK-STAT cascade
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
