dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002990
Uniprot Accession O77263; TRMB_DROME; Q9W527;
Genbank Protein ID NP_569978.1;
Genbank Nucleotide ID NM_130622.3;
Protein Name tRNA (guanine-N(7)-)-methyltransferase
Protein Synonyms/Alias tRNA (guanine(46)-N(7))-methyltransferase;tRNA(m7G46)-methyltransferase;
Gene Name CG4045
Gene Synonyms/Alias
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
41YYRQRAHSNPIADHSPHOSIDA;curated21081558; 22817900
48SNPIADHSFDYPARPPHOSIDA;curated21081558; 22817900
Sequence
(Fasta)		MVATGGQAQD QGQNQEPDVL NPTSAVTGLP QKRYYRQRAH SNPIADHSFD YPARPEDVDW 60
RSMYPGIQQG QQVSFADIGC GYGGFLVTLG EMFPEKLSIG MEIRVKVSDY VVDRIAALRR 120
RCADTGAYQN IACLRTNAMK YLPNYFVKGQ LEKMFFLYPD PHFKRAKHKW RIINQALLSE 180
YAYILRKGGL LYTMTDVEDL HKWIVTHMEE HPLYERLTEE EANADPITPK LYQSSEEGAK 240
VVRNKGDHFL AIFRRL 257
Keyword

KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0819--tRNA processing
KW-0820--tRNA-binding
Interpro

IPR029063--SAM-dependent_MTases
IPR025763--Trm8_euk
IPR003358--tRNA_(Gua-N-7)_MeTrfase_Trmb
PROSITE

PS51625--SAM_MT_TRMB
Pfam

PF02390--Methyltransf_4
Gene Ontology

GO:0005634--C:nucleus
GO:0043527--C:tRNA methyltransferase complex
GO:0008176--F:tRNA (guanine-N7-)-methyltransferase activity
GO:0000049--F:tRNA binding
GO:0036265--P:RNA (guanine-N7)-methylation
GO:0030488--P:tRNA methylation
GO:0006400--P:tRNA modification