dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002987
Uniprot Accession O77086; C3G_DROME; Q1ECB6; Q7YU30; Q86B63; Q9W3W3;
Genbank Protein ID NP_572350.2; NP_788867.1;
Genbank Nucleotide ID NM_132122.5; NM_176694.3;
Protein Name Guanine nucleotide-releasing factor 2
Protein Synonyms/Alias CRK SH3-binding GNRP;DC3G;
Gene Name C3G
Gene Synonyms/Alias CG42328;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Guanine nucleotide-releasing protein that binds to SH3 domain of Crk. Transduces signals from Crk to activate RAS. Also involved in MAPK activation.
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
275KLARRARSFKDDLIEPHOSIDA21081558
299NTLGRSHSPHSPRTKPHOSIDA;PhosphoPep 2.021081558; 19060867
302GRSHSPHSPRTKHGTPHOSIDA;PhosphoPep 2.021081558; 19060867
495AESAAQRTSLPDIALPhosphoPep 2.019060867
496ESAAQRTSLPDIALTdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;UniProt18327897; 16381945; 23193290; 21081558; 19060867
523NPMRGSHSTESILRDdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;UniProt18327897; 16381945; 23193290; 21081558; 19060867
524PMRGSHSTESILRDTdbPTM 3.0;Phospho.ELM 9.0;UniProt18327897; 16381945; 23193290
526RGSHSTESILRDTSPdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;UniProt18327897; 16381945; 23193290; 21081558
532ESILRDTSPPPKPPLPHOSIDA;PhosphoPep 2.021081558; 19060867
615VDRLSVRSRSPDENSdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;UniProt18327897; 16381945; 23193290; 21081558; 19060867
617RLSVRSRSPDENSQCPHOSIDA;PhosphoPep 2.021081558; 19060867
863GWASHRSSQSEVAELPHOSIDA21081558
900QWHSKHHSLIEGPRLPhosphoPep 2.019060867
914LQLAGSGSCSAFDQRPhosphoPep 2.019060867
916LAGSGSCSAFDQRHLPhosphoPep 2.019060867
968CNISRNISHSQTMNIPhosphoPep 2.019060867
970ISRNISHSQTMNIMPPhosphoPep 2.019060867
983MPMSKELSPELEMPPPHOSIDA21081558
Sequence
(Fasta)		MPQFDESFLS DCALADRWHF YSYTVKQLPP HPSPKPNRNR NPYPSGASHD DHQHQLHHHH 60
HQQHHHNHHR LWKTQRQSWS PRDTNNNHSL TSNNCNCNSS NTCNSISATG NTLHSIKFHR 120
RRKYKKLARL ALSTPAIPLQ MDVDVDVNVT VDREFDMEMD TPVPLKNAVC HGSISSPSTP 180
GTCSSGIGVG GGGCSSSSNN SINSGSYSTA CTPPPPTHQH HSQHQQLQGT PGGSSRVGGA 240
GAGGGGGVPP APPSAGSSGH KNSLKGTKLA RRARSFKDDL IEKISLMRTT NNTLGRSHSP 300
HSPRTKHGTK APPTTEEVLR STQTLETHVK DISNALKHFR DVILKKKLEV LPGNGTVILE 360
TIASMYSVIQ TYTLNENSAI MSSATLQVYQ SLGKLIKLCD EVMLSEDSGE CASLSNENVR 420
EVIDLLEDAV RNLVTLAQGK LKEQDQCAFR YSGSGLGGIG AAAEIMGAVT ASPGASVPGT 480
GVMRVSAAES AAQRTSLPDI ALTPKERDIL EQHNVNPMRG SHSTESILRD TSPPPKPPLP 540
NRASNPPPLP PKRRSQPSAS AGTVGVGCSS STSTSNQASP LPYAQSHNIS LNSDLDCSSN 600
ISLLNYGVDR LSVRSRSPDE NSQCSFDSAL NHSREEEDQQ QQHQHLRSFP KLAAMMDEDM 660
DKMVSYSAAI DDKTQTPLST GGGIAGVAGG TGGAGEGVAA AASGDGETNS NRHSNESGFV 720
SMREFRTSTQ TTDYSVQSST KSSSSNSEIA FSISESTAVG SSSEYQQISQ LVSHSQRHIS 780
SSSSSCTTTT TSSSTTTGYG SSEVEQLQQQ QQQQTTTTPA DLAPALPPKS IQRSSLTRHD 840
SPGVGDELDE VQSSSGWASH RSSQSEVAEL RQLSPLHHLN HHPHTASAGQ LQQWHSKHHS 900
LIEGPRLQLA GSGSCSAFDQ RHLDQEPPPL PIKKKHILAY MEICSASTRS IEQHRHTMHA 960
CNISRNISHS QTMNIMPMSK ELSPELEMPP ALPPKNYKQR KATSMVASPT LQPVIVTTPP 1020
PSPKPTLGEN GSTGRPDSRM ATVCEELNDA VASEDAMPEP RSPVLDSNEN VSAVDDGQTF 1080
YCHSHQLPAA EMEMSEDASS ADNQPITTPQ VLEEQEEPTA ESRPLVAVHE SVKPANVDED 1140
EEAERADMLI NMLEEVNITR YLILKKREED GPEVKGGYID ALIVHASRVQ KVADNAFCEA 1200
FITTFRTFIQ PIDVIEKLTH RYTYFFCQVQ DNKQKAAKET FALLVRVVND LTSTDLTSQL 1260
LSLLVEFVYQ LVCSGQLYLA KLLRNKFVEK VTLYKEPKVY GFVGELGGAG SVGGAGIAGS 1320
GGCSGTAGGG NQPSLLDLKS LEIAEQMTLL DAELFTKIEI PEVLLFAKDQ CEEKSPNLNK 1380
FTEHFNKMSY WARSKILRLQ DAKEREKHVN KFIKIMKHLR KMNNYNSYLA LLSALDSGPI 1440
RRLEWQKGIT EEVRSFCALI DSSSSFRAYR QALAETNPPC IPYIGLILQD LTFVHVGNQD 1500
YLSKGVINFS KRWQQYNIID NMKRFKKCAY PFRRNERIIR FFDNFKDFMG EEEMWQISEK 1560
IKPRGRRPVN Y 1572
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0344--Guanine-nucleotide releasing factor
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0729--SH3-binding
Interpro

IPR000651--Ras-like_Gua-exchang_fac_N
IPR019804--Ras_G-nucl-exch_fac_CS
IPR023578--Ras_GEF_dom
IPR001895--RASGEF_cat_dom
PROSITE

PS00720--RASGEF
PS50009--RASGEF_CAT
PS50212--RASGEF_NTER
Pfam

PF00617--RasGEF
PF00618--RasGEF_N
Gene Ontology

GO:0005622--C:intracellular
GO:0017034--F:Rap guanyl-nucleotide exchange factor activity
GO:0005088--F:Ras guanyl-nucleotide exchange factor activity
GO:0016203--P:muscle attachment
GO:0043547--P:positive regulation of GTPase activity
GO:0007265--P:Ras protein signal transduction
GO:0043087--P:regulation of GTPase activity
GO:0045214--P:sarcomere organization
GO:0007525--P:somatic muscle development