| Tag |
Content |
| dbPAF ID |
dbPAF-0002963 |
| Uniprot Accession |
O76460; RAD54_DROME; B6UXG7; B6UXH8; B6UXJ2; B6UXJ5; P91636; Q7K0T1; Q7KPH9;
|
| Genbank Protein ID |
NP_476661.1;
|
| Genbank Nucleotide ID |
NM_057313.5;
|
| Protein Name |
DNA repair and recombination protein RAD54-like |
| Protein Synonyms/Alias |
|
| Gene Name |
okr |
| Gene Synonyms/Alias |
RAD54;CG3736; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.Functional Description
Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MRRSLAPSQR GPLRPESRHS FTPPLLKKNK RSCQQELERE QELDRRRLGA LRDASNTSEL 60
PLPIRFTANS EYELAIAKVL ARKFKVPMDN YVPDYGGKRV LGVRRCISRR PLHDPMACNA 120
LVLFHPPAYT EHERMGMDPT KVLVHVVVDP LLSNILRPHQ REGVRFMYEC VEGKRGNFNG 180
CIMADEMGLG KTLQCVTLVW TLLRQGPECK PTINKAIVVS PSSLVKNWEK EFTKWLHGRL 240
LCLPMEGGTK ENTIRALEQF SMTSARLGTP VLLISYETFR IYAEILCKYE VGMVICDEGH 300
RLKNSDNLTY QALMGLKTKR RVLLSGTPIQ NDLTEYYSLV NFVNPEMLGT AAVFKRNFES 360
AILRGQNTDS TEQERQRAIE KTQELIGLVD QCIIRRTNQI LTKYLPVKFE MVICAKLTAI 420
QLELYTNFLK SDQVRRSLAD CNEKASLTAL ADITTLKKIC SHPDLIYEKL TAREKGFENS 480
QNVLPSNYKP KDLNPELSGK FMLLDFMLAA IRAEGNDKVV LISNYTQTLD LFEQLARKRK 540
YGFVRLDGTM SIKKRSKVVD RFNDPESDSF LFMLSSKAGG CGLNLIGANR LFMFDPDWNP 600
ANDEQAMARV WRDGQKKPCY IYRLVASGSI EEKILQRQTH KKSLSSTIID NNESAEKHFT 660
RDDLKDLFTF DANILSDTHD KLKCKRCVQN IQMKPPPEDT DCTSHLSQWY HCSNNRGLPD 720
NILAQAWMDC KCVSFVFHHR SQAQEIVPSA EEEATDQPEE KPESRKRSST PASDDSADED 780
FRGF
785Fasta Sequence
>O76460|okr|Drosophila melanogaster(Fruit fly)
MRRSLAPSQRGPLRPESRHSFTPPLLKKNKRSCQQELEREQELDRRRLGALRDASNTSELPLPIRFTANSEYELAIAKVLARKFKVPMDNYVPDYGGKRVLGVRRCISRRPLHDPMACNALVLFHPPAYTEHERMGMDPTKVLVHVVVDPLLSNILRPHQREGVRFMYECVEGKRGNFNGCIMADEMGLGKTLQCVTLVWTLLRQGPECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKENTIRALEQFSMTSARLGTPVLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADCNEKASLTALADITTLKKICSHPDLIYEKLTAREKGFENSQNVLPSNYKPKDLNPELSGKFMLLDFMLAAIRAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTIIDNNESAEKHFTRDDLKDLFTFDANILSDTHDKLKCKRCVQNIQMKPPPEDTDCTSHLSQWYHCSNNRGLPDNILAQAWMDCKCVSFVFHHRSQAQEIVPSAEEEATDQPEEKPESRKRSSTPASDDSADEDFRGF
|
| Keyword |
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0469--Meiosis
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
|
| Interpro |
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
|
| PROSITE |
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
|
| Pfam |
PF00271--Helicase_C
PF00176--SNF2_N
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0051301--P:cell division
GO:0006338--P:chromatin remodeling
GO:0030261--P:chromosome condensation
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0043150--P:DNA synthesis involved in double-strand break repair via homologous recombination
GO:0046843--P:dorsal appendage formation
GO:0006302--P:double-strand break repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0045003--P:double-strand break repair via synthesis-dependent strand annealing
GO:0008298--P:intracellular mRNA localization
GO:0000711--P:meiotic DNA repair synthesis
GO:0007067--P:mitotic nuclear division
GO:0048477--P:oogenesis
GO:0007131--P:reciprocal meiotic recombination
GO:0006417--P:regulation of translation
GO:0010212--P:response to ionizing radiation
|
