| Tag |
Content |
| dbPAF ID |
dbPAF-0002952 |
| Uniprot Accession |
O76324; DCO_DROME; A4V3P5; Q0KHY4; Q9V462;
|
| Genbank Protein ID |
NP_001263132.1; NP_524602.1; NP_733414.1; NP_733415.1;
|
| Genbank Nucleotide ID |
NM_001276203.1; NM_079863.3; NM_170535.2; NM_170536.3;
|
| Protein Name |
Discs overgrown protein kinase |
| Protein Synonyms/Alias |
Protein double-time; |
| Gene Name |
dco |
| Gene Synonyms/Alias |
dbt;CG2048; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Involved in circadian rhythms, viability and molecular oscillations of the clock genes period (per) and timeless (tim). Dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation. No evident circadian oscillation is detected in head. Together with CkIalpha, regulates processing of ci by phosphorylating it which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase (PubMed:16326393).Functional Description
Involved in circadian rhythms, viability and molecular oscillations of the clock genes period (per) and timeless (tim). Dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation. No evident circadian oscillation is detected in head. Together with CkIalpha, regulates processing of ci by phosphorylating it which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase (PubMed:16326393). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MELRVGNKYR LGRKIGSGSF GDIYLGTTIN TGEEVAIKLE CIRTKHPQLH IESKFYKTMQ 60
GGIGIPRIIW CGSEGDYNVM VMELLGPSLE DLFNFCSRRF SLKTVLLLAD QMISRIDYIH 120
SRDFIHRDIK PDNFLMGLGK KGNLVYIIDF GLAKKFRDAR SLKHIPYREN KNLTGTARYA 180
SINTHLGIEQ SRRDDLESLG YVLMYFNLGA LPWQGLKAAN KRQKYERISE KKLSTSIVVL 240
CKGFPSEFVN YLNFCRQMHF DQRPDYCHLR KLFRNLFHRL GFTYDYVFDW NLLKFGGPRN 300
PQAIQQAQDG ADGQAGHDAV AAAAAVAAAA AASSHQQQQH KVNAALGGGG GSAAQQQLQG 360
GQTLAMLGGN GGGNGSQLIG GNGLNMDDSM AATNSSRPPY DTPERRPSIR MRQGGGGGGG 420
GVGVGGMPSG GGGGGVGNAK
441Fasta Sequence
>O76324|dco|Drosophila melanogaster(Fruit fly)
MELRVGNKYRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKHPQLHIESKFYKTMQGGIGIPRIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDYIHSRDFIHRDIKPDNFLMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGALPWQGLKAANKRQKYERISEKKLSTSIVVLCKGFPSEFVNYLNFCRQMHFDQRPDYCHLRKLFRNLFHRLGFTYDYVFDWNLLKFGGPRNPQAIQQAQDGADGQAGHDAVAAAAAVAAAAAASSHQQQQHKVNAALGGGGGSAAQQQLQGGQTLAMLGGNGGGNGSQLIGGNGLNMDDSMAATNSSRPPYDTPERRPSIRMRQGGGGGGGGVGVGGMPSGGGGGGVGNAK
|
| Keyword |
KW-0067--ATP-binding
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
|
| Interpro |
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
|
| PROSITE |
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
|
| Pfam |
PF00069--Pkinase
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0016301--F:kinase activity
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0048148--P:behavioral response to cocaine
GO:0007154--P:cell communication
GO:0007623--P:circadian rhythm
GO:0008062--P:eclosion rhythm
GO:0006897--P:endocytosis
GO:0001737--P:establishment of imaginal disc-derived wing hair orientation
GO:0042067--P:establishment of ommatidial planar polarity
GO:0007446--P:imaginal disc growth
GO:0045475--P:locomotor rhythm
GO:0043066--P:negative regulation of apoptotic process
GO:0018105--P:peptidyl-serine phosphorylation
GO:0016310--P:phosphorylation
GO:0051781--P:positive regulation of cell division
GO:0030307--P:positive regulation of cell growth
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045732--P:positive regulation of protein catabolic process
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0008360--P:regulation of cell shape
GO:0042752--P:regulation of circadian rhythm
GO:0042306--P:regulation of protein import into nucleus
GO:0007622--P:rhythmic behavior
GO:0030431--P:sleep
GO:0016055--P:Wnt signaling pathway
|
