dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002445
Uniprot Accession O70608; SYCP2_RAT;
Genbank Protein ID NP_570091.1; XP_008760769.1;
Genbank Nucleotide ID NM_130735.1; XM_008762547.1;
Protein Name Synaptonemal complex protein 2
Protein Synonyms/Alias
Gene Name Sycp2
Gene Synonyms/Alias Scp2;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
113NSKEIILSQRQSKDEPhosphoSitePlus22135298
494TDRYTVRSPILLINTPhosphoSitePlus;UniProt22135298; 22673903
503ILLINTSTPRRSRAPPhosphoSitePlus;UniProt22135298; 22673903
516APLQAIHSAEKAVSKPhosphoSitePlus;UniProt22135298; 22673903
651CTKQKSVSDDDSEETPhosphoSitePlus;UniProt22135298; 22673903
655KSVSDDDSEETQRVKPhosphoSitePlus;UniProt22135298; 22673903
936DDSKTDISWLRKPKSPhosphoSitePlus22135298
1025SESEKEISYLFKDKLPhosphoSitePlus22135298
1121DYDYITKSLSPYPKAPhosphoSitePlus22135298
1123DYITKSLSPYPKAASPhosphoSitePlus;UniProt22135298; 22673903
1130SPYPKAASPEFLNRSPhosphoSitePlus;UniProt22135298; 22673903
1146RVVGHGKSPRISETScurated23800682
1160SAVCVRKSCSPASGLcurated23800682
1162VCVRKSCSPASGLPFPhosphoSitePlus;UniProt22135298; 22673903
1170PASGLPFSPRHTTKNPhosphoSitePlus;UniProt22135298; 22673903
1218KLYMEPESPDSCENHPhosphoSitePlus;UniProt;curated22135298; 22673903; 23800682
1221MEPESPDSCENHVQSPhosphoSitePlus;UniProt;curated22135298; 22673903; 23800682
1237REENHAASPFSLSSEPhosphoSitePlus;UniProt22135298; 22673903
1240NHAASPFSLSSEKIEPhosphoSitePlus;curated22135298; 23800682
1280YLEEDELSNPSEAEVPhosphoSitePlus;UniProt;curated22135298; 22673903; 23800682; 24117733
Sequence
(Fasta)		MPVRPDPQQL EKCIDDALRK NDFKPLVTLL QIDICEDVKI KCSKQFLRKL DDLICRELHK 60
KDIQTISNIL ISIGRCSKNI FILGQTGLQT MIKQGLVQKM VSWFENSKEI ILSQRQSKDE 120
AVMNMIEDLF DLLMVVYDVN DEGKNQVLES FIPHICALVI DSRVNFCIQQ EALKKMNLML 180
DRIPQDANKI LCNQEILTLM SNMGERILDV GDYELQVGIV EALCRMTTEK RRQELAYEWF 240
SMDFIANAFK KIKDCEFETD CRIFLNLVNG MLGDRRRVFT FPCLSAFLGK YELQIPSDEK 300
LEEFWIDFNL GSHTLSFYIA GDDDDHQWEA VTVPEEKVDM YNIEVRESKK LLTLTLKNIV 360
KISKKEGKEL LLYFDAALEI TNVTKKLFGG NKYKEFTRKQ DISVAKTSIH VLFDASGSQI 420
LVPESQPSPV KENLIHLKEK SNLQKKLTNP LEPDNSSSQR DRKNSQDEIT TPSRKKMSEA 480
SMIVPDTDRY TVRSPILLIN TSTPRRSRAP LQAIHSAEKA VSKTSESGVD YAVSLKSRQS 540
DGRNRGNNRA NHNKTATVQN KGHEHHESPD QTFNEIEETL SDAYAVEKVD KPVLPGVLDI 600
SKNKAHSRWA CWTPVTTIKL CNNQRSCALP GDTFTQDTGV NKKCTKQKSV SDDDSEETQR 660
VKYSKDVIKC NKSEEAEVCE RNIQEQNHPK YSQKKNTANA KKNDWHIESE TTYKSVLLNK 720
TTEESLIYKK TCVLSKDVNT TICDKSPSRK SMRSHTKSRK ELMSEVTSCE LDEIPVRENS 780
KGKRFTGTAE SLINLINKRY NSSDDMISTR KLKEPRDGSG FSKKPELQFN KVQRKSYRKL 840
KTVVNVTSEC PLNDVYNFSL NGADEPVIKL GIQEFQATTR EASMDNSIKL VDVRNRDERD 900
LSLKTKDERI LSHERKTLFS DTETECGWDD SKTDISWLRK PKSKRLMDYS RNKNTKKCKS 960
IKSRSSTEKG QPRSTVVLSK NIAKNDYEVI VDGRTRLPRR ATKTKKNYKD LSTSGSESES 1020
EKEISYLFKD KLPTKEETVH SSAQTKKLPK KQQKVFNTEA LKGQPSEEQK NSSTLRNGRE 1080
DSLYLSSASV SGSSSSVEVM RCTEKITERD FTQDYDYITK SLSPYPKAAS PEFLNRSNRV 1140
VGHGKSPRIS ETSAVCVRKS CSPASGLPFS PRHTTKNNSV MNIKNTNSVI NNQRTQHCNS 1200
YSDVSSNSSE KLYMEPESPD SCENHVQSKR EENHAASPFS LSSEKIEKIW FDMPNDNTHV 1260
SGPSQRGSKR RMYLEEDELS NPSEAEVQEA EEREHLVSKK LCQREHFDQH TSETSLSTPE 1320
FSVPKDWQQE LQGAGMFYDN INSDYKRKTD TQHKIMDDFT TKTLKLTQQH LLAMACQARG 1380
HRDENIDKFQ VTLLDELEKV EKDSQTLRDL EKEFVDIEEK IVHKMRAFHQ SERERFRALK 1440
TSLDKSLLVY NSVYEENVLT SEMCLMKANM KMLQDKLLKE MHEEELLNIR RGLESLFKDH 1500
EGNNA 1506
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0469--Meiosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR016024--ARM-type_fold
IPR024835--SYCP1/2
IPR024832--SYCP2
PROSITE
Pfam
Gene Ontology

GO:0000800--C:lateral element
GO:0005634--C:nucleus
GO:0000795--C:synaptonemal complex
GO:0003677--F:DNA binding
GO:0051301--P:cell division
GO:0007143--P:female meiotic division
GO:0009566--P:fertilization
GO:0048808--P:male genitalia morphogenesis
GO:0007140--P:male meiosis
GO:0043066--P:negative regulation of apoptotic process