| Tag |
Content |
| dbPAF ID |
dbPAF-0002443 |
| Uniprot Accession |
O70594; S22A5_RAT; Q9QWL0;
|
| Genbank Protein ID |
NP_062142.1;
|
| Genbank Nucleotide ID |
NM_019269.1;
|
| Protein Name |
Solute carrier family 22 member 5 |
| Protein Synonyms/Alias |
CT1;High-affinity sodium-dependent carnitine cotransporter;Organic cation/carnitine transporter 2;UST2r; |
| Gene Name |
Slc22a5 |
| Gene Synonyms/Alias |
Octn2; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.Functional Description
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MRDYDEVTAF LGEWGPFQRL IFFLLSASII PNGFNGMSIV FLAGTPEHRC LVPHTVNLSS 60
AWRNHSIPLE TKDGRQVPQS CRRYRLATIA NFSALGLEPG RDVDLEQLEQ ENCLDGWEYN 120
KDVFLSTIVT EWDLVCKDDW KAPLTTSLFF VGVLMGSFIS GQLSDRFGRK NVLFLTMGMQ 180
TGFSFLQLFS VNFEMFTVLF VLVGMGQISN YVAAFVLGTE ILSKSIRIIF ATLGVCIFYA 240
FGFMVLPLFA YFIRDWRMLL LALTVPGVLC GALWWFIPES PRWLISQGRV KEAEVIIRKA 300
AKFNGIVAPS TIFDPSELQD LNSKKPQSHH IYDLVRTRNI RIITIMSIIL WLTISVGYFG 360
LSLDTPNLHG DIYVNCFLLA AVEVPAYVLA WLLLQHLPRR YSISAALFLG GSVLLFIQLV 420
PSELFYLSTA LVMVGKFGIT SAYSMVYVYT AELYPTVVRN MGVGVSSTAS RLGSILSPYF 480
VYLGAYDRFL PYILMGSLTI LTAILTLFFP ESFGAPLPDT IDQMLRVKGI KQWQIQSQTR 540
TQKDGGESPT VLKSTAF
558Fasta Sequence
>O70594|Slc22a5|Rattus norvegicus(Rat)
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQLFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFDPSELQDLNSKKPQSHHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLLFIQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFPESFGAPLPDTIDQMLRVKGIKQWQIQSQTRTQKDGGESPTVLKSTAF
|
| Keyword |
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0406--Ion transport
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0915--Sodium
KW-0739--Sodium transport
KW-0769--Symport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR020846--MFS_dom
IPR005828--MFS_sugar_transport_like
IPR004749--Orgcat_transp/SVOP
IPR005829--Sugar_transporter_CS
|
| PROSITE |
PS50850--MFS
PS00216--SUGAR_TRANSPORT_1
|
| Pfam |
PF00083--Sugar_tr
|
| Gene Ontology |
GO:0016323--C:basolateral plasma membrane
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0042895--F:antibiotic transporter activity
GO:0005524--F:ATP binding
GO:0015226--F:carnitine transmembrane transporter activity
GO:0015491--F:cation:cation antiporter activity
GO:0015651--F:quaternary ammonium group transmembrane transporter activity
GO:0015293--F:symporter activity
GO:0042891--P:antibiotic transport
GO:0009437--P:carnitine metabolic process
GO:1902603--P:carnitine transmembrane transport
GO:0015879--P:carnitine transport
GO:0098655--P:cation transmembrane transport
GO:0072337--P:modified amino acid transport
GO:0015695--P:organic cation transport
GO:0015697--P:quaternary ammonium group transport
GO:0006814--P:sodium ion transport
|
