dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002427
Uniprot Accession O70511; ANK3_RAT; Q574D7; Q574D8; Q574D9; Q574E0; Q574E2; Q8VDA0;
Genbank Protein ID NP_001029156.1; NP_113993.1;
Genbank Nucleotide ID NM_001033984.1; NM_031805.1;
Protein Name Ankyrin-3
Protein Synonyms/Alias
Gene Name Ank3
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 25 (View all)
PositionPeptidesSourceReferences ( PMIDs )
541NAATTSGYTPLHLSAPhosphoSitePlus22135298
631LLLDQGASPHAAAKNPhosphoSitePlus;UniProt22135298; 22673903
640HAAAKNGYTPLHIAAPhosphoSitePlus22135298
818ARRLGYISVVDTLKVPhosphoSitePlus22135298
855MNEVLDMSDDEVGKAPhosphoSitePlus;UniProt22135298; 22673903
869ASAPEKLSDGEYISDPhosphoSitePlus;UniProt22135298; 22673903
875LSDGEYISDGEEGEDPhosphoSitePlus;UniProt22135298; 22673903
921SLGARSASLRSFSSDPhosphoSitePlus;UniProt22135298; 22673903
924ARSASLRSFSSDRSYPhosphoSitePlus;UniProt22135298; 22673903
965PFTREFDSDSLRHYSPhosphoSitePlus;UniProt22135298; 22673903
967TREFDSDSLRHYSWAPhosphoSitePlus;UniProt22135298; 22673903
1121GMDEELDSPEELGTKPhosphoSitePlus;UniProt22135298; 22673903
1378KPIYVDCYGNLAPLTPhosphoSitePlus22135298
1396QQLVFNFYSFKENRLPhosphoSitePlus22135298
1458EKADRRQSFTSLALRPhosphoSitePlus;UniProt22135298; 22673903
1679SPLKSVVSPTKSAADPhosphoSitePlus22135298
1683SVVSPTKSAADVISTPhosphoSitePlus22135298
1984PKSDKGHSPEDDWTEPhosphoSitePlus;UniProt22135298; 22673903
2102GTDAILESPDDFSQHPhosphoSitePlus;UniProt22135298; 22673903
2107LESPDDFSQHDQDKSPhosphoSitePlus22135298
Sequence
(Fasta)		MAHAASQLKK NRDLEINAEE ETEKKKKHRK RSRDRKKKSD ANASYLRAAR AGHLEKALDY 60
IKNGVDVNIC NQNGLNALHL ASKEGHVEVV SELLQREANV DAATKKGNTA LHIASLAGQA 120
EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE NHLEVVRFLL DNGASQSLAT EDGFTPLAVA 180
LQQGHDQVVS LLLENDTKGK VRLPALHIAA RKDDTKAAAL LLQNDTNADI ESKMVVNRAT 240
ESGFTPLHIA AHYGNINVAT LLLNRAAAVD FTARNDITPL HVASKRGNAN MVKLLLDRGA 300
KIDAKTRDGL TPLHCGARSG HEQVVEMLLD RAAPILSKTK NGLSPLHMAT QGDHLNCVQL 360
LLQHNVPVDD VTNDYLTALH VAAHCGHYKV AKVLLDKKAN PNAKALNGFT PLHIACKKNR 420
IRVMELLLKH GASIQAVTES GLTPIHVAAF MGHVNIVSQL MHHGASPNTT NVRGETALHM 480
AARSGQAEVV RYLVQDGAQV EAKAKDDQTP LHISARLGKA DIVQQLLQQG ASPNAATTSG 540
YTPLHLSARE GHEDVAAFLL DHGASLSITT KKGFTPLHVA AKYGKLEVAS LLLQKSASPD 600
AAGKSGLTPL HVAAHYDNQK VALLLLDQGA SPHAAAKNGY TPLHIAAKKN QMDIATSLLE 660
YGADANAVTR QGIASVHLAA QEGHVDMVSL LLSRNANVNL SNKSGLTPLH LAAQEDRVNV 720
AEVLVNQGAH VDAQTKMGYT PLHVGCHYGN IKIVNFLLQH SAKVNAKTKN GYTPLHQAAQ 780
QGHTHIINVL LQNNASPNEL TVNGNTALAI ARRLGYISVV DTLKVVTEEI MTTTTITEKH 840
KMNVPETMNE VLDMSDDEVG KASAPEKLSD GEYISDGEEG EDAITGDTDK YLGPQDLKEL 900
GDDSLPAEGY VGFSLGARSA SLRSFSSDRS YTLNRSSYAR DSMMIEELLV PSKEQHLPFT 960
REFDSDSLRH YSWAADTLDN VNLVSSPVHS GFLVSFMVDA RGGSMRGSRH HGMRIIIPPR 1020
KCTAPTRITC RLVKRHKLAN PPPMVEGEGL ASRLVEMGPA GAQFLGPVIV EIPHFGSMRG 1080
KERELIVLRS ENGETWKEHQ FDSKNEDLSE LLNGMDEELD SPEELGTKRI CRIITKDFPQ 1140
YFAVVSRIKQ ESNQIGPEGG ILSSTTVPLV QASFPEGALT KRIRVGLQAQ PVPEETVKKI 1200
LGNKATFSPI VTVEPRRRKF HKPITMTIPV PPPSGEGVSN GYKGDTTPSL RLLCSITGGT 1260
SPAQWEDITG TTPLTFIKDC VSFTTNVSAR FWLADCHQVL ETVGLASQLY RELICVPYMA 1320
KFVVFAKTND PVESSLRCFC MTDDRVDKTL EQQENFEEVA RSKDIEVLEG KPIYVDCYGN 1380
LAPLTKGGQQ LVFNFYSFKE NRLPFSIKVR DTSQEPCGRL SFLKEPKTTK GLPQTAVCNL 1440
NITLPAHKKA EKADRRQSFT SLALRKRYSY LTEPSMKTVE RSSGTARSLP TTYSHKPFFS 1500
TRPYQSWTTT PITVPGPAKS GSLSSSPSNT PSASPLKSIW SVSTPSPIKS TLGASTTSSV 1560
KSISDVASPI RSFRTISSPI RTVASPSPYN TQVASGTLGR VPTITEATPI KGVAPNSTLS 1620
SRTSPVTTAG SLLEKSSITM TPPASPKANI TMYSSSLPFK SIITSAAPLI SSPLKSVVSP 1680
TKSAADVIST AKAAMASTLS SPLKQMSGHA EVALVNGSVS PLKYPSSSAL INGCKATATL 1740
QDKISTATNA VSSVVSAAPD TVEKALSTTT AMPFSPLRSY VSAAAPSAFQ SLRAPSASAL 1800
YNSLGPSVGV TTSSVTSSII TVPVYSVGNV LAEPALKKLP DSNSLTKSAA ALLSPIKTLT 1860
TETRPQPHFN RTSSPVKSSL FLASSALKPS VPSSLSSSQE ILKDVAEMKE DLMRMTAILQ 1920
TDVPEEKPFQ TDLPREGRID DEEPFKIVEK VKEDLVKVSE ILKKDVCVES KGPPKSPKSD 1980
KGHSPEDDWT EFSSEEIREA RQAAASHAPS LPERVHGKAN LTRVIDYLTN DIGSSSLTNL 2040
KYKFEEAKKE GEERQKRILK PAMALQEHKL KMPPASMRPS TSEKELCKMA DSFFGTDAIL 2100
ESPDDFSQHD QDKSPLSDSG FETRSEKTPS APQSAESTGP KPLFHEVPIP PVITETRTEV 2160
VHVIRSYEPS TGEIPQSQPE DPVSPKPPPT FMELEPKPTA LSIKEKVKAF QMKASSEEED 2220
HSRVLSKGMR VKEETHITTT TRMVYHSPPG SECASERIEE TMSVHDIMKA FQSGRDPSKE 2280
LAGLFEHKSA MSPDVAKSAA ETSAQHAEKD NQMKPKLERI IEVHIEKGPQ SPCERTDIRM 2340
AIVADHLGLS WTELARELNF SVDEINQIRV ENPNSLISQS FMLLKKWVTR DGKNATTDAL 2400
TSVLTKINRI DIVTLLEGPI FDYGNISGTR SFADENNVFH DPVDGWQNET PSGSLESPAQ 2460
ARRITGGLLD RLDDSSDQVR DPITSYLTGE AGKFEANGNH AEVIPEAKAK AYFPESQNDI 2520
GKQSIKENLK PKTHGCGRAE EPVSPLTAYQ KSLEETSKLV IEDAPKPCVP VGMKKMTRTP 2580
ADGKARLNLQ EEEGSARSEP KQGEGYKVKT KKEIRNVEKK AH 2623
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0458--Lysosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011029--DEATH-like_dom
IPR000488--Death_domain
IPR000906--ZU5_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50017--DEATH_DOMAIN
PS51145--ZU5
Pfam

PF00023--Ank
PF12796--Ank_2
PF13606--Ank_3
PF00531--Death
PF00791--ZU5
Gene Ontology

GO:0043194--C:axon initial segment
GO:0009986--C:cell surface
GO:0043034--C:costamere
GO:0030425--C:dendrite
GO:0014704--C:intercalated disc
GO:0005764--C:lysosome
GO:0031594--C:neuromuscular junction
GO:0043005--C:neuron projection
GO:0033268--C:node of Ranvier
GO:0005886--C:plasma membrane
GO:0045211--C:postsynaptic membrane
GO:0042383--C:sarcolemma
GO:0016529--C:sarcoplasmic reticulum
GO:0014731--C:spectrin-associated cytoskeleton
GO:0030315--C:T-tubule
GO:0030018--C:Z disc
GO:0045296--F:cadherin binding
GO:0008092--F:cytoskeletal protein binding
GO:0044325--F:ion channel binding
GO:0030674--F:protein binding, bridging
GO:0030507--F:spectrin binding
GO:0071286--P:cellular response to magnesium ion
GO:0010960--P:magnesium ion homeostasis
GO:0071709--P:membrane assembly
GO:1902260--P:negative regulation of delayed rectifier potassium channel activity
GO:0007528--P:neuromuscular junction development
GO:2001259--P:positive regulation of cation channel activity
GO:0010650--P:positive regulation of cell communication by electrical coupling
GO:0010628--P:positive regulation of gene expression
GO:0034112--P:positive regulation of homotypic cell-cell adhesion
GO:1900827--P:positive regulation of membrane depolarization during cardiac muscle cell action potential
GO:0045838--P:positive regulation of membrane potential
GO:0090314--P:positive regulation of protein targeting to membrane
GO:2000651--P:positive regulation of sodium ion transmembrane transporter activity
GO:0010765--P:positive regulation of sodium ion transport
GO:0072659--P:protein localization to plasma membrane
GO:0043266--P:regulation of potassium ion transport
GO:0007165--P:signal transduction