dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002404
Uniprot Accession O70441; SYN3_RAT;
Genbank Protein ID NP_058805.1;
Genbank Nucleotide ID NM_017109.1;
Protein Name Synapsin-3
Protein Synonyms/Alias Synapsin III;
Gene Name Syn3
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
9NFLRRRLSDSSFVANdbPTM 3.0;PhosphoSitePlus10571231; 16381945; 23193290; 22135298
404VPGASVPSPLRPWGPPhosphoSitePlus22135298
461SPSQQRLSPQGQQPVPhosphoSitePlus;UniProt22135298; 22673903
469PQGQQPVSPQSGSPQPhosphoSitePlus;UniProt22135298; 22673903
474PVSPQSGSPQQQRSPPhosphoSitePlus;UniProt22135298; 22673903
480GSPQQQRSPGSPQLSPhosphoSitePlus;UniProt22135298; 22673903
483QQQRSPGSPQLSRASPhosphoSitePlus;UniProt22135298; 22673903
540PHLNKSQSLTNSLSTPhosphoSitePlus;UniProt22135298; 22673903
572TIRNLRKSFASLFSDPhosphoSitePlus22135298
575NLRKSFASLFSD---PhosphoSitePlus22135298
578KSFASLFSD------PhosphoSitePlus22135298
Sequence
(Fasta)		MNFLRRRLSD SSFVANLPNG YMPDLQRPES SSSSPASPAT ERRHPQPLAA SFSSPGSSLF 60
SSFSSAMKQT PQAPTGLMEP PTPVTPVVQR PRILLVIDDA HTDWSKYFHG KKVNGDIEIR 120
VEQAEFSELN LAAYVTGGCM VDMQVVRNGT KIVRSFKPDF ILVRQHAYSM ALAEDYRSLV 180
IGLQYGGLPA VNSLYSVYNF CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMLTAP 240
NFPVVIKLGH AHAGMGKIKV ENQHDYQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN 300
YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV KAVHSKNGRD 360
YIIEVMDSSM PLIGEHVEED KQLMADLVVS KMSQLLVPGA SVPSPLRPWG PQTKSAKSPG 420
QGQLGPLLGQ PQPRPPPQGG PRQAQSPQPP RSRSPSQQRL SPQGQQPVSP QSGSPQQQRS 480
PGSPQLSRAS GGSSPNQASK PTASLSSHTR PPVQGRSTSQ QGEEPQKTAS PHPHLNKSQS 540
LTNSLSTSDT SHRGTPSEDE AKAETIRNLR KSFASLFSD
Keyword

KW-0067--ATP-binding
KW-0106--Calcium
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
Interpro

IPR013815--ATP_grasp_subdomain_1
IPR013816--ATP_grasp_subdomain_2
IPR016185--PreATP-grasp_dom
IPR001359--Synapsin
IPR020898--Synapsin_ATP-bd_dom
IPR019735--Synapsin_CS
IPR019736--Synapsin_P_site
IPR020897--Synapsin_pre-ATP-grasp_dom
PROSITE

PS00415--SYNAPSIN_1
PS00416--SYNAPSIN_2
Pfam

PF02078--Synapsin
PF02750--Synapsin_C
PF10581--Synapsin_N
Gene Ontology

GO:0030054--C:cell junction
GO:0008021--C:synaptic vesicle
GO:0030672--C:synaptic vesicle membrane
GO:0005524--F:ATP binding
GO:0003824--F:catalytic activity
GO:0007269--P:neurotransmitter secretion