| Tag |
Content |
| dbPAF ID |
dbPAF-0002388 |
| Uniprot Accession |
O70351; HCD2_RAT; Q9QYD4;
|
| Genbank Protein ID |
NP_113870.1;
|
| Genbank Nucleotide ID |
NM_031682.1;
|
| Protein Name |
3-hydroxyacyl-CoA dehydrogenase type-2 |
| Protein Synonyms/Alias |
17-beta-hydroxysteroid dehydrogenase 10;17-beta-HSD 10; |
| Gene Name |
Hsd17b10 |
| Gene Synonyms/Alias |
Erab;Hadh2; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (By similarity).Functional Description
Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MAAAVRSVKG LVAVITGGAS GLGLSTAKRL VGQGATAVLL DVPNSEGETE AKKLGGNCIF 60
APANVTSEKE VQAALTLAKE KFGRIDVAVN CAGIAVAIKT YHEKKNQVHT LEDFQRVINV 120
NLIGTFNVIR LVAGVMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIVGMTL 180
PIARDLAPIG IRVVTIAPGL FATPLLTTLP DKVRNFLASQ VPFPSRLGDP AEYAHLVQMV 240
IENPFLNGEV IRLDGAIRMQ P
262Fasta Sequence
>O70351|Hsd17b10|Rattus norvegicus(Rat)
MAAAVRSVKGLVAVITGGASGLGLSTAKRLVGQGATAVLLDVPNSEGETEAKKLGGNCIFAPANVTSEKEVQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHEKKNQVHTLEDFQRVINVNLIGTFNVIRLVAGVMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVVTIAPGLFATPLLTTLPDKVRNFLASQVPFPSRLGDPAEYAHLVQMVIENPFLNGEVIRLDGAIRMQP
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0496--Mitochondrion
KW-0520--NAD
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0819--tRNA processing
|
| Interpro |
IPR002198--DH_sc/Rdtase_SDR
IPR002347--Glc/ribitol_DH
IPR016040--NAD(P)-bd_dom
IPR020904--Sc_DH/Rdtase_CS
|
| PROSITE |
PS00061--ADH_SHORT
|
| Pfam |
PF00106--adh_short
|
| Gene Ontology |
GO:0005739--C:mitochondrion
GO:0047015--F:3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
GO:0003857--F:3-hydroxyacyl-CoA dehydrogenase activity
GO:0018454--F:acetoacetyl-CoA reductase activity
GO:0001540--F:beta-amyloid binding
GO:0004303--F:estradiol 17-beta-dehydrogenase activity
GO:0030331--F:estrogen receptor binding
GO:0042802--F:identical protein binding
GO:0051287--F:NAD binding
GO:0005496--F:steroid binding
GO:0030283--F:testosterone dehydrogenase [NAD(P)] activity
GO:0007569--P:cell aging
GO:0033327--P:Leydig cell differentiation
GO:0051289--P:protein homotetramerization
GO:0008033--P:tRNA processing
|
