| Tag |
Content |
| dbPAF ID |
dbPAF-0002368 |
| Uniprot Accession |
O70260; PIAS3_RAT;
|
| Genbank Protein ID |
NP_113972.2;
|
| Genbank Nucleotide ID |
NM_031784.2;
|
| Protein Name |
E3 SUMO-protein ligase PIAS3 |
| Protein Synonyms/Alias |
KChAP;Potassium channel-associated protein;Protein inhibitor of activated STAT protein 3; |
| Gene Name |
Pias3 |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1. Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity).Functional Description
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1. Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA PSVQMKIKEL 60
YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP SPLASIPPTL LTPGTLLGPK REVDMHPPLP 120
QPVHPDVTMK PLPFYEVYGE LIRPTTLAST SSQRFEEAHF TFALTPQQLQ QILTSREVLP 180
GAKCDYTIQV QLRFCLCETS CPQEDYFPPN LFVKVNGKLC PLPGYLPPTK NGAEPKRPSR 240
PINITPLARL SATVPNTIVV NWSSEFGRNY SLSVYLVRQL TAGTLLQKLR AKGIRNPDHS 300
RALIKEKLTA DPDSEVATTS LRVSLMCPLG KMRLTVPCRA LTCAHLQSFD AALYLQMNEK 360
KPTWTCPVCD KKAPYESLII DGLFMEILNS CSDCDEIQFM EDGSWCPMKP KKEASEVCPP 420
PGYGLDGLQY SPVQEGNQSE NKKRVEVIDL TIESSSDEED LPPTKKHCPV TSAAIPALPG 480
SKGALTSGHQ PSSVLRSPAM GTLGSDFLSS LPLHEYPPAF PLGADIQGLD LFSFLQTESQ 540
HYSPSVITSL DEQDTLGHFF QFRGTPPHFL GPLAPTLGSS HRSATPAPAP GRVSSIVAPG 600
SSLREGHGGP LPSGPSLTGC RSDVISLD
629Fasta Sequence
>O70260|Pias3|Rattus norvegicus(Rat)
MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPSPLASIPPTLLTPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQEGNQSENKKRVEVIDLTIESSSDEEDLPPTKKHCPVTSAAIPALPGSKGALTSGHQPSSVLRSPAMGTLGSDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYSPSVITSLDEQDTLGHFFQFRGTPPHFLGPLAPTLGSSHRSATPAPAPGRVSSIVAPGSSLREGHGGPLPSGPSLTGCRSDVISLD
|
| Keyword |
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR027226--PIAS3
IPR023321--PINIT
IPR003034--SAP_dom
IPR004181--Znf_MIZ
|
| PROSITE |
PS51466--PINIT
PS50800--SAP
PS51044--ZF_SP_RING
|
| Pfam |
PF14324--PINIT
PF02891--zf-MIZ
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0045202--C:synapse
GO:0016874--F:ligase activity
GO:0015459--F:potassium channel regulator activity
GO:0008022--F:protein C-terminus binding
GO:0047485--F:protein N-terminus binding
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0033234--P:negative regulation of protein sumoylation
GO:0010628--P:positive regulation of gene expression
GO:0045838--P:positive regulation of membrane potential
GO:0033235--P:positive regulation of protein sumoylation
GO:0016925--P:protein sumoylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009725--P:response to hormone
GO:0006351--P:transcription, DNA-templated
|
