dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0002360 |
| Uniprot Accession | O70244; CUBN_RAT; |
| Genbank Protein ID | NP_445784.1; |
| Genbank Nucleotide ID | NM_053332.2; |
| Protein Name | Cubilin |
| Protein Synonyms/Alias | 460 kDa receptor;Glycoprotein 280;gp280;Intrinsic factor-cobalamin receptor;Intrinsic factor-vitamin B12 receptor; |
| Gene Name | Cubn |
| Gene Synonyms/Alias | Ifcr; |
| Organism | Rattus norvegicus(Rat) |
| NCBI Taxa ID | 10116 |
| Functional Description (View all) |
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MSSQFLWGFV TLLMIAELDG KTGKPEQRGQ KRIADLHQPR MTTEEGNLVF LTSSTQNIEF 60 RTGSLGKIKL NDEDLGECLH QIQRNKDDII DLRKNTTGLP QNILSQVHQL NSKLVDLERD 120 FQNLQQNVER KVCSSNPCLN GGTCVNLHDS FVCICPSQWK GLFCSEDVNE CVVYSGTPFG 180 CQSGSTCVNT VGSFRCDCTP DTYGPQCASK YNDCEQGSKQ LCKHGICEDL QRVHHGQPNF 240 HCICDAGWTT PPNGISCTED KDECSLQPSP CSEHAQCFNT QGSFYCGACP KGWQGNGYEC 300 QDINECEINN GGCSQAPLVP CLNTPGSFSC GNCPAGFSGD GRVCTPVDIC SIHNGGCHPE 360 ATCSSSPVLG SFLPVCTCPP GYTGNGYGSN GCVRLSNICS RHPCVNGQCI ETVSSYFCKC 420 DSGWSGQNCT ENINDCSSNP CLNGGTCIDG INGFTCDCTS SWTGYYCQTP QAACGGILSG 480 TQGTFAYHSP NDTYIHNVNC FWIVRTDEEK VLHVTFTFFD LESASNCPRE YLQIHDGDSS 540 ADFPLGRYCG SRPPQGIHSS ANALYFHLYS EYIRSGRGFT ARWEAKLPEC GGILTDNYGS 600 ITSPGYPGNY PPGRDCVWQV LVNPNSLITF TFGTLSLESH NDCSKDYLEI RDGPFHQDPV 660 LGKFCTSLST PPLKTTGPAA RIHFHSDSET SDKGFHITYL TTQSDLDCGG NYTDTDGELL 720 LPPLSGPFSH SRQCVYLITQ AQGEQIVINF THVELESQMG CSHTYIEVGD HDSLLRKICG 780 NETLFPIRSV SNKVWIRLRI DALVQKASFR ADYQVACGGM LRGEGFFRSP FYPNAYPGRR 840 TCRWTISQPQ RQVVLLNFTD FQIGSSASCD TDYIEIGPSS VLGSPGNEKF CSSNIPSFIT 900 SVYNILYVTF VKSSSMENRG FTAKFSSDKL ECGEVLTAST GIIESPGHPN VYPRGVNCTW 960 HVVVQRGQLI RLEFSSFYLE FHYNCTNDYL EIYDTAAQTF LGRYCGKSIP PSLTSNSNSI 1020 KLIFVSDSAL AHEGFSINYE AIDASSVCLY DYTDNFGMLS SPNFPNNYPS NWECIYRITV 1080 GLNQQIALHF TDFTLEDYFG SQCVDFVEIR DGGYETSPLV GIYCGSVLPP TIISHSNKLW 1140 LKFKSDAALT AKGFSAYWDG SSTGCGGNLT TPTGVLTSPN YPMPYYHSSE CYWRLEASHG 1200 SPFELEFQDF HLEHHPSCSL DYLAVFDGPT TNSRLIDKLC GDTTPAPIRS NKDVVLLKLR 1260 TDAGQQGRGF EINFRQRCDN VVIVNKTSGI LESINYPNPY DKNQRCNWTI QATTGNTVNY 1320 TFLGFDVESY MNCSTDYVEL YDGPQWMGRY CGNNMPPPGA TTGSQLHVLF HTDGINSGEK 1380 GFKMQWFTHG CGGEMSGTAG SFSSPGYPNS YPHNKECIWN IRVAPGSSIQ LTIHDFDVEY 1440 HTSCNYDSLE IYAGLDFNSP RIAQLCSQSP SANPMQVSST GNELAIRFKT DSTLNGRGFN 1500 ASWRAVPGGC GGIIQLSRGE IHSPNYPNNY RANTECSWII QVERHHRVLL NITDFDLEAP 1560 DSCLRLMDGS SSTNARVASV CGRQQPPNSI IASGNSLFVR FRSGSSSQNR GFRAEFREEC 1620 GGRIMTDSSD TIFSPLYPHN YLHNQNCSWI IEAQPPFNHI TLSFTHFQLQ NSTDCTRDFV 1680 EILDGNDYDA PVQGRYCGFS LPHPIISFGN ALTVRFVTDS TRSFEGFRAI YSASTSSCGG 1740 SFYTLDGIFN SPDYPADYHP NAECVWNIAS SPGNRLQLSF LSFNLENSLN CNKDFVEIRE 1800 GNATGHLIGR YCGNSLPGNY SSAEGHSLWV RFVSDGSGTG MGFQARFKNI FGNNNIVGTH 1860 GKIASPFWPG KYPYNSNYKW VVNVDAYHII HGRILEMDIE PTTNCFYDSL KIYDGFDTHS 1920 RLIGTYCGTQ TESFSSSRNS LTFQFSSDSS VSGRGFLLEW FAVDVSDSTP PTIAPGACGG 1980 FMVTGDTPVH IFSPGWPREY ANGADCIWII YAPDSTVELN ILSLDIEPQQ SCNYDKLIVK 2040 DGDSDLSPEL AVLCGVSPPG PIRSTGEYMY IRFTSDTSVA GTGFNASFHK SCGGYLHADR 2100 GVITSPKYPD TYLPNLNCSW HVLVQTGLTI AVHFEQPFQI QNRDSFCSQG DYLVLRNGPD 2160 NHSPPLGPSG RNGRFCGMYA PSTLFTSGNE MFVQFISDSS NGGQGFKIRY EAKSLACGGT 2220 VYIHDADSDG YLTSPNYPAN YPQHAECIWI LEAPPGRSIQ LQFEDQFNIE DTPNCSVSYL 2280 ELRDGANSNA RLVSKLCGHT LPHSWVSSRE RIYLKFHTDG GSSYMGFKAK YSIASCGGTV 2340 SGDSGVIESI GYPTLPYANN VFCQWFIRGL PGHYLTLSFE DFNLQSSPGC TKDFVEIWEN 2400 HTSGRVLGRY CGNSTPSSVD TSSNVASVKF VTDGSVTASG FRLQFKSSRQ VCGGDLHGPT 2460 GTFTSPNYPN PNPHARICEW TITVQEGRRI VLTFTNLRLS TQPSCNSEHL IVFNGIRSNS 2520 PLLQKLCSRV NVTNEFKSSG NTMKVVFFTD GSRPYGGFTA SYTSTEDAVC GGFLPSVSGG 2580 NFSSPGYNGI RDYARNLDCE WTLSNPNREN SSISIYFLEL SIESHQDCTF DVLEFRVGDA 2640 DGPLIEKFCS LSAPTAPLVI PYPQVWIHFV SNERVEYTGF YIEYSFTDCG GIRTGDNGVI 2700 SSPNYPNLYS AWTHCSWLLK APEGHTITLT FSDFLLEAHP TCTSDSVTVR NGDSPGSPVI 2760 GRYCGQSVPR PIQSGSNQLI VTFNTNNQGQ TRGFYATWTT NALGCGGTFH SANGTIKSPH 2820 WPQTFPENSR CSWTVITHES KHWEISFDSN FRIPSSDSQC QNSFVKVWEG RLMINKTLLA 2880 TSCGDVAPSP IVTSGNIFTA VFQSEEMAAQ GFSASFISRC GRTFNTSPGD IISPNFPKQY 2940 DNNMNCTYLI DADPQSLVIL TFVSFHLEDR SAITGTCDHD GLHIIKGRNL SSTPLVTICG 3000 SETLRPLTVD GPVLLNFYSD AYTTDFGFKI SYRAITCGGI YNESSGILRS PSYSYSNYPN 3060 NLYCVYSLHV RSSRVIIIRF NDFDVAPSNL CAHDFLEVFD GPSIGNRSLG KFCGSTRPQT 3120 VKSTNSSLTL LFKTDSSQTA RGWKIFFRET IGPQQGCGGY LTEDNQSFVS PDSDSNGRYD 3180 KGLSCIWYIV APENKLVKLT FNVFTLEGPS SAGSCVYDYV QIADGASINS YLGGKFCGSR 3240 MPAPFISSGN FLTFQFVSDV TVEMRGFNAT YTFVDMPCGG TYNATSTPQN ASSPHLSNIG 3300 RPYSTCTWVI AAPPQQQVQI TVWDLQLPSQ DCSQSYLELQ DSVQTGGNRV TQFCGANYTT 3360 LPVFYSSMST AVVVFKSGVL NRNSQVQFSY QIADCNREYN QTFGNLKSPG WPQNYDNNLD 3420 CTIILRAPQN HSISLFFYWF QLEDSRQCMN DFLEVRNGGS STSPLLDKYC SNLLPNPVFS 3480 QSNELYLHFH SDHSVTNNGY EIIWTSSAAG CGGTLLGDEG IFTNPGFPDS YPNNTHCEWT 3540 IVAPSGRPVS VGFPFLSIDS SGGCDQNYLI VFNGPDANSP PFGPLCGINT GIAPFYASSN 3600 RVFIRFHAEY TTRLSGFEIM WSS 3624 |
| Keyword | KW-0106--Calcium |
| Interpro | IPR000859--CUB_dom |
| PROSITE | PS00010--ASX_HYDROXYL |
| Pfam | |
| Gene Ontology | GO:0031526--C:brush border membrane |