dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0002352
Uniprot Accession O70199; UGDH_RAT;
Genbank Protein ID NP_112615.1;
Genbank Nucleotide ID NM_031325.1;
Protein Name UDP-glucose 6-dehydrogenase
Protein Synonyms/Alias
Gene Name Ugdh
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
Phosphorylation Sites
dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
47ARINAWNSPTLPIYEcurated23984901
91LVFISVNTPTKTYGMcurated22817900
461TIGFQIETIGKKVSSPhosphoSitePlus;curated22135298; 22817900
473VSSKRIPYTPGEIPKPhosphoSitePlus22135298
474SSKRIPYTPGEIPKFdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16396499; 16641100; 16381945; 23193290; 18779572; 22135298;
Sequence
(Fasta)
MVEIKKICCI GAGYVGGPTC SVIARMCPEI RVTVVDVNEA RINAWNSPTL PIYEPGLKEV 60
VESCRGKNLF FSTNIDDAIR EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS 120
NGYKIVTEKS TVPVRAAESI RRIFDANTKP NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI 180
GGDETPEGQR AVQALCAVYE HWVPKEKILT TNTWSSELSK LAANAFLAQR ISSINSISAL 240
CESTGADVEE VATAIGMDQR IGNKFLKASV GFGGGCFQKD VLNLVYLCEA LNLPEVARYW 300
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE 360
GAHLHIYDPK VPREQIVVDL SHPGVSADDQ VSRLVTISKD PYEACDGAHA LVICTEWDMF 420
KELDYERIHK RMLKPAFIFD GRRVLDGLHN ELQTIGFQIE TIGKKVSSKR IPYTPGEIPK 480
FSLQDPPNKK PKV 494
Keyword

KW-0007--Acetylation
KW-0021--Allosteric enzyme
KW-0181--Complete proteome
KW-0520--NAD
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR008927--6-PGluconate_DH_C-like
IPR016040--NAD(P)-bd_dom
IPR017476--UDP-Glc/GDP-Man
IPR014027--UDP-Glc/GDP-Man_DH_C
IPR014026--UDP-Glc/GDP-Man_DH_dimer
IPR001732--UDP-Glc/GDP-Man_DH_N
IPR028356--UDPglc_DH_euk

PROSITE
Pfam

PF00984--UDPG_MGDP_dh
PF03720--UDPG_MGDP_dh_C
PF03721--UDPG_MGDP_dh_N

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0051287--F:NAD binding
GO:0003979--F:UDP-glucose 6-dehydrogenase activity
GO:0005975--P:carbohydrate metabolic process
GO:0006024--P:glycosaminoglycan biosynthetic process
GO:0006065--P:UDP-glucuronate biosynthetic process