dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002351
Uniprot Accession O70196; PPCE_RAT;
Genbank Protein ID NP_112614.1;
Genbank Nucleotide ID NM_031324.1;
Protein Name Prolyl endopeptidase
Protein Synonyms/Alias
Gene Name Prep
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has high activity on the succinyl- (suc-) peptide-4-methylcoumaryl-7-amide (MCA) substrates suc-Gly-Pro-Leu-Gly-Pro-MCA, suc-Gly-Pro-MCA and suc-Ala-Ala-Ala-MCA.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
71KERMTELYDYPKYSCPhosphoSitePlus22135298
90GKRYFYFYNTGLQNQPhosphoSitePlus22135298
658KFIATLQYIVGRSRKPhosphoSitePlus22135298
Sequence
(Fasta)		MLSFQYPDVY RDETSVQDYH GHKICDPYAW LEDPDSEQTK AFVEAQNKIT VPFLEQCPIR 60
GLYKERMTEL YDYPKYSCHF KKGKRYFYFY NTGLQNQRVL YVQDSLEGEA RVFLDPNTLS 120
DDGTVALRGY AFSEDGEYFA YGLSASGSDW VTIKFMKVDG AKELPDVLER VKFTCMAWTH 180
DGKGMFYNSY PQQDGKSDGT ETSTNLHQKL CYHVLGTDQS EDVLCAEFPD EPKWMGGAEL 240
SDDGRYVLLS IWEGCDPVNR LWYCDLQQGS NGINGILKWV KLIDNFEGEY DYITNEGTVF 300
TFKTNRNSPN YRLINIDFTD PDESKWKVLV PEHEKDVLEW VACVRSNFLV LCYLRNVKNI 360
LQLHDLTTGA LLKTFPLDVG SVVGYSGRKK DSEIFYQFTS FLSPGVIYHC DLTREELEPR 420
VFREVTVKGI DASDYQTIQV FYPSKDGTKI PMFIVHKKGI KLDGSHPAFL YGYGGFNISI 480
TPNYSVSRLI FVRHMGGVLA VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE 540
GYTTSKRLTI NGGSNGGLLV AACANQRPDL FGCVIAQVGV MDMLKFHKFT IGHAWTTDYG 600
CSDSKQHFEW LLKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSL KFIATLQYIV 660
GRSRKQSNPL LIHVDTKAGH GPGKPTAKVI EEVSDMFAFI ARCLNIEWIQ 711
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0720--Serine protease
Interpro

IPR029058--AB_hydrolase
IPR002471--Pept_S9_AS
IPR023302--Pept_S9A_N
IPR001375--Peptidase_S9
IPR002470--Peptidase_S9A
PROSITE

PS00708--PRO_ENDOPEP_SER
Pfam

PF00326--Peptidase_S9
PF02897--Peptidase_S9_N
Gene Ontology

GO:0005829--C:cytosol
GO:0004175--F:endopeptidase activity
GO:0042277--F:peptide binding
GO:0004252--F:serine-type endopeptidase activity
GO:0070008--F:serine-type exopeptidase activity
GO:0006508--P:proteolysis