dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002348
Uniprot Accession O70188; O70188_RAT;
Genbank Protein ID NP_113755.1;
Genbank Nucleotide ID NM_031567.1;
Protein Name Nuclear factor 1
Protein Synonyms/Alias
Gene Name Nfic
Gene Synonyms/Alias NF1-C;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
194RDAEQSSSPRTGVGSPhosphoSitePlus;SysPTM 2.0;curated22135298; 16396499; 19366988; 22817900; 21630457; 24945867
279PSTSSSGSKRHKSGScurated23984901
284SGSKRHKSGSMEEDVcurated21630457; 24945867
293SMEEDVDTSPGGDYYcurated23984901
294MEEDVDTSPGGDYYTPhosphoSitePlus22135298
299DTSPGGDYYTSPNSPPhosphoSitePlus;curated22135298; 22817900; 21630457; 24945867
300TSPGGDYYTSPNSPTPhosphoSitePlus;curated22135298; 22817900; 21630457
301SPGGDYYTSPNSPTSPhosphoSitePlus;curated22135298; 22817900
302PGGDYYTSPNSPTSSPhosphoSitePlus;curated22135298; 22817900; 21630457
305DYYTSPNSPTSSSRNPhosphoSitePlus;curated22135298; 22817900; 21630457; 23589303; 24945867
307YTSPNSPTSSSRNWTPhosphoSitePlus;curated22135298; 22817900; 21630457
308TSPNSPTSSSRNWTEPhosphoSitePlus;curated22135298; 22817900
309SPNSPTSSSRNWTEDPhosphoSitePlus;curated22135298; 22817900
310PNSPTSSSRNWTEDMPhosphoSitePlus;curated22135298; 22817900; 21630457
314TSSSRNWTEDMEGGIcurated23712012; 21630457
322EDMEGGISSPVKKTEcurated23712012; 21630457
323DMEGGISSPVKKTEMPhosphoSitePlus;curated22135298; 22817900; 21630457; 22276854
333KKTEMDKSPFNSPSPPhosphoSitePlus;curated22135298; 23712012; 21630457; 23984901; 24945867
337MDKSPFNSPSPQDSPcurated23712012; 21630457
339KSPFNSPSPQDSPRLPhosphoSitePlus;curated22135298; 22817900; 21630457; 22276854
Sequence
(Fasta)		MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE 60
LLGEKAEVKQ KWASRLLAKL RKDIRPECRE DFVLAVTGKK APGCVLSNPD QKGKMRRIDC 120
LRQADKVWRL DLVMVILFKG IPLESTDGER LVKAAACAHP VLCVQPHHIG VAVKELDLYL 180
AYFVRERDAE QSSSPRTGVG SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV 240
TGTGPNFSLG ELQGHLAYDL NPASAGMRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY 300
TSPNSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT QHHRPVIAVH 360
SGIARSPHPS SALHFPATPI LPQTASTYFP HTAIRYPPHL NPQDPLKDLV SLACDPATQQ 420
PGPPALRPAR PLQTVPLWD
Keyword

KW-0010--Activator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR000647--CTF/NFI
IPR020604--CTF/NFI_DNA-bd-dom
IPR019739--CTF/NFI_DNA-bd_CS
IPR019548--CTF/NFI_DNA-bd_N
IPR003619--MAD_homology1_Dwarfin-type
PROSITE

PS00349--CTF_NFI_1
PS51080--CTF_NFI_2
Pfam

PF00859--CTF_NFI
PF03165--MH1
PF10524--NfI_DNAbd_pre-N
Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0001159--F:core promoter proximal region DNA binding
GO:0003677--F:DNA binding
GO:0003690--F:double-stranded DNA binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0006260--P:DNA replication
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007608--P:sensory perception of smell