dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0002347
Uniprot Accession O70185; O70185_RAT; F1LLY9;
Genbank Protein ID XP_006238398.1;
Genbank Nucleotide ID XM_006238336.2;
Protein Name Nuclear factor 1
Protein Synonyms/Alias
Gene Name Nfib
Gene Synonyms/Alias NF1-B;rCG_55296;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Phosphorylation Sites
dbPAF PTMs: 24 (View all)
PositionPeptidesSourceReferences ( PMIDs )
264VNLQRSLSSPPSSKRPhosphoSitePlus;curated22135298; 23712012; 21630457
265NLQRSLSSPPSSKRPPhosphoSitePlus;curated22135298; 23712012; 21630457
269SLSSPPSSKRPKTIScurated21630457
274PSSKRPKTISIDENMPhosphoSitePlus;curated22135298; 23712012; 21630457; 24945867
276SKRPKTISIDENMEPPhosphoSitePlus;curated22135298; 23712012
284IDENMEPSPTGDFYPcurated23712012; 21630457; 23984901
286ENMEPSPTGDFYPSPcurated23712012; 21630457
290PSPTGDFYPSPNSPAcurated23712012; 21630457; 24945867
292PTGDFYPSPNSPAAGPhosphoSitePlus;curated22135298; 23712012; 21630457
295DFYPSPNSPAAGSRTPhosphoSitePlus;curated22135298; 23712012; 21630457; 24945867
300PNSPAAGSRTWHERDPhosphoSitePlus;curated22135298; 23712012; 21630457; 23984901
311HERDQDMSSPTTMKKPhosphoSitePlus;curated22135298; 23984901
312ERDQDMSSPTTMKKPPhosphoSitePlus;curated22135298; 23712012; 21630457
314DQDMSSPTTMKKPEKPhosphoSitePlus;curated22135298; 21630457
325KPEKPLFSSTSPQDScurated23984901
326PEKPLFSSTSPQDSScurated21630457
327EKPLFSSTSPQDSSPcurated23712012; 21630457
328KPLFSSTSPQDSSPRPhosphoSitePlus;curated22135298; 23712012; 21630457
332SSTSPQDSSPRLSTFcurated23712012; 21630457
333STSPQDSSPRLSTFPPhosphoSitePlus;curated22135298; 23712012; 21630457; 23984901
Sequence
(Fasta)
MMYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE 60
LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK HPCCVLSNPD QKGKIRRIDC 120
LRQADKVWRL DLVMVILFKG IPLESTDGER LMKSPHCTNP ALCVQPHHIT VSVKELDLFL 180
AYYVQEQDSG QSGSPSHNDP AKNPPGYLED SFVKSGVFNV SELVRVSRTP ITQGTGVNFP 240
IGEIPSQPYY HDMNSGVNLQ RSLSSPPSSK RPKTISIDEN MEPSPTGDFY PSPNSPAAGS 300
RTWHERDQDM SSPTTMKKPE KPLFSSTSPQ DSSPRLSTFP QHHHPGIPGV AHSVISTRTP 360
PPPSPLPFPT QAILPPAPSS YFSHPTIRYP PHLNPQDTLK NYVPSYDPSS PQTSQPNSSG 420
QVVGKVPGHF TPVLAPSPHP SAVRPVTLTM TDTKPITTST EAYTASGTSQ ANRYVGLSPR 480
DPSFLHQQQL RICDWTMNQN GRHLYPSTSE DTLGITWQSP GTWASLVPFQ VSNRTPILPA 540
NVQNYGLNII GEPFLQAETS N 562
Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR000647--CTF/NFI
IPR020604--CTF/NFI_DNA-bd-dom
IPR019739--CTF/NFI_DNA-bd_CS
IPR019548--CTF/NFI_DNA-bd_N
IPR003619--MAD_homology1_Dwarfin-type

PROSITE

PS00349--CTF_NFI_1
PS51080--CTF_NFI_2

Pfam

PF00859--CTF_NFI
PF03165--MH1
PF10524--NfI_DNAbd_pre-N

Gene Ontology

GO:0044300--C:cerebellar mossy fiber
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003690--F:double-stranded DNA binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001106--F:RNA polymerase II transcription corepressor activity
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0021960--P:anterior commissure morphogenesis
GO:0060689--P:cell differentiation involved in salivary gland development
GO:0002062--P:chondrocyte differentiation
GO:0060486--P:Clara cell differentiation
GO:0071679--P:commissural neuron axon guidance
GO:0006260--P:DNA replication
GO:0010001--P:glial cell differentiation
GO:0030902--P:hindbrain development
GO:0061141--P:lung ciliated cell differentiation
GO:0043392--P:negative regulation of DNA binding
GO:2000795--P:negative regulation of epithelial cell proliferation involved in lung morphogenesis
GO:2000791--P:negative regulation of mesenchymal cell proliferation involved in lung development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0021740--P:principal sensory nucleus of trigeminal nerve development
GO:0060662--P:salivary gland cavitation
GO:0007608--P:sensory perception of smell
GO:0060509--P:Type I pneumocyte differentiation
GO:0060510--P:Type II pneumocyte differentiation