Tag |
Content |
dbPAF ID |
dbPAF-0002347 |
Uniprot Accession |
O70185; O70185_RAT; F1LLY9; |
Genbank Protein ID |
XP_006238398.1; |
Genbank Nucleotide ID |
XM_006238336.2; |
Protein Name |
Nuclear factor 1 |
Protein Synonyms/Alias |
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Gene Name |
Nfib |
Gene Synonyms/Alias |
NF1-B;rCG_55296; |
Organism |
Rattus norvegicus(Rat) |
NCBI Taxa ID |
10116 |
Functional Description (View all) |
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.Functional Description
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
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Phosphorylation Sites
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dbPAF PTMs: 24 (View all) |
Sequence (Fasta) | MMYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE 60 LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK HPCCVLSNPD QKGKIRRIDC 120 LRQADKVWRL DLVMVILFKG IPLESTDGER LMKSPHCTNP ALCVQPHHIT VSVKELDLFL 180 AYYVQEQDSG QSGSPSHNDP AKNPPGYLED SFVKSGVFNV SELVRVSRTP ITQGTGVNFP 240 IGEIPSQPYY HDMNSGVNLQ RSLSSPPSSK RPKTISIDEN MEPSPTGDFY PSPNSPAAGS 300 RTWHERDQDM SSPTTMKKPE KPLFSSTSPQ DSSPRLSTFP QHHHPGIPGV AHSVISTRTP 360 PPPSPLPFPT QAILPPAPSS YFSHPTIRYP PHLNPQDTLK NYVPSYDPSS PQTSQPNSSG 420 QVVGKVPGHF TPVLAPSPHP SAVRPVTLTM TDTKPITTST EAYTASGTSQ ANRYVGLSPR 480 DPSFLHQQQL RICDWTMNQN GRHLYPSTSE DTLGITWQSP GTWASLVPFQ VSNRTPILPA 540 NVQNYGLNII GEPFLQAETS N
562Fasta Sequence
>O70185|Nfib|Rattus norvegicus(Rat) MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPNSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSTSPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNSSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLTMTDTKPITTSTEAYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQAETSN
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Keyword |
KW-0010--Activator KW-0181--Complete proteome KW-0235--DNA replication KW-0238--DNA-binding KW-0539--Nucleus KW-1267--Proteomics identification KW-1185--Reference proteome KW-0804--Transcription KW-0805--Transcription regulation
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Interpro |
IPR000647--CTF/NFI IPR020604--CTF/NFI_DNA-bd-dom IPR019739--CTF/NFI_DNA-bd_CS IPR019548--CTF/NFI_DNA-bd_N IPR003619--MAD_homology1_Dwarfin-type
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PROSITE |
PS00349--CTF_NFI_1 PS51080--CTF_NFI_2
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Pfam |
PF00859--CTF_NFI PF03165--MH1 PF10524--NfI_DNAbd_pre-N
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Gene Ontology |
GO:0044300--C:cerebellar mossy fiber GO:0005730--C:nucleolus GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0003690--F:double-stranded DNA binding GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0001106--F:RNA polymerase II transcription corepressor activity GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0021960--P:anterior commissure morphogenesis GO:0060689--P:cell differentiation involved in salivary gland development GO:0002062--P:chondrocyte differentiation GO:0060486--P:Clara cell differentiation GO:0071679--P:commissural neuron axon guidance GO:0006260--P:DNA replication GO:0010001--P:glial cell differentiation GO:0030902--P:hindbrain development GO:0061141--P:lung ciliated cell differentiation GO:0043392--P:negative regulation of DNA binding GO:2000795--P:negative regulation of epithelial cell proliferation involved in lung morphogenesis GO:2000791--P:negative regulation of mesenchymal cell proliferation involved in lung development GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0045892--P:negative regulation of transcription, DNA-templated GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0045893--P:positive regulation of transcription, DNA-templated GO:0021740--P:principal sensory nucleus of trigeminal nerve development GO:0060662--P:salivary gland cavitation GO:0007608--P:sensory perception of smell GO:0060509--P:Type I pneumocyte differentiation GO:0060510--P:Type II pneumocyte differentiation
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