dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002334
Uniprot Accession O70143; SHC3_RAT;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name SHC-transforming protein 3
Protein Synonyms/Alias Neuronal Shc;N-Shc;SHC-transforming protein C;Src homology 2 domain-containing-transforming protein C3;SH2 domain protein C3;
Gene Name Shc3
Gene Synonyms/Alias Nshc;Shcc;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
74KVSHLKLSSSGLRGLdbPTM 3.0;curated18779572; 16381945; 23193290
75VSHLKLSSSGLRGLSdbPTM 3.0;curated18779572; 16381945; 23193290
94ERAGARLSGSCSAPSdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
98ARLSGSCSAPSLAAPdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
111APDGGSATPGSRAPAdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
120GSRAPAASMSATRKSdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
122RAPAASMSATRKSRAdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
341GDGPDHPYYNSVPNKPhosphoSitePlus22135298
342DGPDHPYYNSVPNKMPhosphoSitePlus22135298
406RQGSLDIYSTPEGKAPhosphoSitePlus22135298
Sequence
(Fasta)		MLPRTKYNRF RNDSVTSVDD LLHSLSVSGS GGKVSAEPAA SPYLVSGEAL RKAPDDGPGS 60
LGHLLHKVSH LKLSSSGLRG LSSAARERAG ARLSGSCSAP SLAAPDGGSA TPGSRAPAAS 120
MSATRKSRAS DEPLPRPPRG APHASDQVLG SGVTYVVKYL GCIEVLRSMR SLDFSTRTQV 180
TREAISRVCE AVPGAKGAFK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD 240
SKQIISNHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 300
FELRFKQYLQ CPSKIPALQD RMQSLDEPWT EEEGDGPDHP YYNSVPNKMP PPGGFLDARL 360
KARPHAPDAA QFSGKEQTYY QGRHLGDAFG EDWQRAPTRQ GSLDIYSTPE GKAHMVPVGE 420
TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPVLS KAASVECISP 480
VTPRAPDAKM LEELNAEPWY QGEMSRKEAE ALLQEDGDFL VRKSTTNPGS FVLTGMHNGQ 540
AKHLLLVDPE GTVRTKDRVF DSISHLITYH LESSLPIVSA GSELCLRQPV ERKP 595
Keyword

KW-0024--Alternative initiation
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
Interpro

IPR011993--PH/PTB_dom
IPR006019--PID_Shc-like
IPR006020--PTB/PI_dom
IPR000980--SH2
IPR029593--Shc3/ShcC/N-Shc
PROSITE

PS01179--PID
PS50001--SH2
Pfam

PF00640--PID
PF00017--SH2
Gene Ontology

GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0001784--F:phosphotyrosine binding
GO:0019901--F:protein kinase binding
GO:0005102--F:receptor binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0007417--P:central nervous system development
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0035556--P:intracellular signal transduction