dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002329
Uniprot Accession O70127; ABCBB_RAT;
Genbank Protein ID NP_113948.1;
Genbank Nucleotide ID NM_031760.1;
Protein Name Bile salt export pump
Protein Synonyms/Alias ATP-binding cassette sub-family B member 11;Sister of P-glycoprotein;
Gene Name Abcb11
Gene Synonyms/Alias Bsep;Spgp;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
2------MSDSVILRSPhosphoSitePlus22135298
4----MSDSVILRSVKPhosphoSitePlus22135298
9SDSVILRSVKKFGEEcurated23984901
25HAFESDGSHNNDKKSPhosphoSitePlus22135298
290EVLSSIRTVAAFGGEPhosphoSitePlus22135298
679KDATEGGTLERTFSRPhosphoSitePlus22135298
703SIRQRSKSQLSLLTHPhosphoSitePlus;UniProt22135298; 22673903
706QRSKSQLSLLTHDPPPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
1321VITGAPIS-------PhosphoSitePlus;UniProt22135298; 22673903
Sequence
(Fasta)		MSDSVILRSV KKFGEENHAF ESDGSHNNDK KSRLQDKMKE GDIRVGFFEL FRFSSSKDIW 60
LMLMGGVCAL LHGMAQPGIL IIFGIMTDIF IKYDIERQEL EIPGKACVNN TIVWINSSFH 120
QNMTNGTVCG LVDIESEMIK FSGIYAGVGM TVLILGYFQI RLWVITGARQ IRRMRKIYFR 180
RIMRMEIGWF DCTSVGELNS RFADDIEKIN DAIADQLAHF LQRMSTAMCG LLLGFYRGWK 240
LTLVILAVSP LIGIGAAVIG LSIAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE 300
VERYEKNLVF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSTLVLD EEEYTPGTLV 360
QIFLCVILAA MNIGHASSCL EIFSTGCSAA TNIFQTIDRQ PVIDCMSGDG YKLDRIKGEI 420
EFHNVTFHYP SRPDVKILDN LSMVIKPGET TALVGSSGAG KSTALQLIQR FYDPCEGMVT 480
LDGHDIRSLN IRWLRDQIGI VEQEPVLFST TIAENIRFGR EDATMEDIVQ AAKDANAYNF 540
IMALPQQFDT LVGEGGGQMS GGQKQRVAIA RALIRNPKIL LLDMATSALD NESEARVQEA 600
LNKIQHGHTI ISVAHRLSTV RAADVIIGFE HGVAVERGTH EELLERKGVY FMLVTLQSQG 660
DNAHKETSIM GKDATEGGTL ERTFSRGSYR DSLRASIRQR SKSQLSLLTH DPPLAVADHK 720
SSYKDSKDND VLVEEVEPAP VRRILKYNIP EWHYILVGSL SAAINGAVTP IYSLLFSQLL 780
GTFSLLDKEQ QRSEIHSMCL FFVILGCVSI FTQFLQGYTF AKSGELLTKR LRKFGFKAML 840
GQDIGWFDDL RNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIIAAL LIAFFFSWKL 900
SLIITIFFPF LALSGAVQTK MLTGFASQDK QALEKAGQIT SEALSNIRTV AGIGVEGRFI 960
KAFEVELQTS YKTAVRKANI YGLCFAFSQG IAFLANSAAY RYGGYLIAYE GLGFSHVFRV 1020
VSSVALSATA VGRTFSYTPS YAKAKISAAR FFQLLDRKPP INVYSEAGEK WDNFQGKIDF 1080
IDCKFTYPSR PDIQVLNGLS VSVNPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID 1140
GHDSKKVNIQ FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF 1200
VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD TESEKTVQTA 1260
LDKAREGRTC IVIAHRLSTI QNSDIIAVVS QGVVIEKGTH EKLMAQKGAY YKLVITGAPI 1320
S 1322
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR003593--AAA+_ATPase
IPR011527--ABC1_TM_dom
IPR003439--ABC_transporter-like
IPR017871--ABC_transporter_CS
IPR030278--BSEP
IPR027417--P-loop_NTPase
PROSITE

PS50929--ABC_TM1F
PS00211--ABC_TRANSPORTER_1
PS50893--ABC_TRANSPORTER_2
Pfam

PF00664--ABC_membrane
PF00005--ABC_tran
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0042626--F:ATPase activity, coupled to transmembrane movement of substances
GO:0015126--F:canalicular bile acid transmembrane transporter activity
GO:0015238--F:drug transmembrane transporter activity
GO:0015722--P:canalicular bile acid transport
GO:0046618--P:drug export
GO:0006855--P:drug transmembrane transport
GO:0042493--P:response to drug
GO:0043627--P:response to estrogen
GO:0006979--P:response to oxidative stress