| Tag |
Content |
| dbPAF ID |
dbPAF-0002325 |
| Uniprot Accession |
O62618; MK14A_DROME; A4V3C0; O46216; Q9TXB4;
|
| Genbank Protein ID |
NP_001163711.1; NP_477163.1; NP_732959.1;
|
| Genbank Nucleotide ID |
NM_001170240.2; NM_057815.5; NM_170126.5;
|
| Protein Name |
Mitogen-activated protein kinase 14A |
| Protein Synonyms/Alias |
|
| Gene Name |
Mpk2 |
| Gene Synonyms/Alias |
p38a;CG5475; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Kinase involved in a signal transduction pathway. May down-regulate insect immunity gene expression after prolonged infection.Functional Description
Kinase involved in a signal transduction pathway. May down-regulate insect immunity gene expression after prolonged infection. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MSVSITKKFY KLDINRTEWE IPDIYQDLQP VGSGAYGQVS KAVVRGTNMH VAIKKLARPF 60
QSAVHAKRTY RELRLLKHMD HENVIGLLDI FHPHPANGSL ENFQQVYLVT HLMDADLNNI 120
IRMQHLSDDH VQFLVYQILR GLKYIHSAGV IHRDLKPSNI AVNEDCELRI LDFGLARPTE 180
NEMTGYVATR WYRAPEIMLN WMHYDQTVDI WSVGCIMAEL ITRRTLFPGT DHIHQLNLIM 240
EMLGTPPAEF LKKISSESAR SYIQSLPPMK GRSFKNVFKN ANPLAIDLLE KMLELDAEKR 300
ITAEEALSHP YLEKYAEPSV EQTSPPYDHS FEDMDLPVDK WKELIYKEVT NFKPPPSYAQ 360
VLKDVK
367Fasta Sequence
>O62618|Mpk2|Drosophila melanogaster(Fruit fly)
MSVSITKKFYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGYVATRWYRAPEIMLNWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQTSPPYDHSFEDMDLPVDKWKELIYKEVTNFKPPPSYAQVLKDVK
|
| Keyword |
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
|
| Interpro |
IPR011009--Kinase-like_dom
IPR003527--MAP_kinase_CS
IPR008352--MAPK_p38
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
|
| PROSITE |
PS01351--MAPK
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
|
| Pfam |
PF00069--Pkinase
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004707--F:MAP kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0016909--F:SAP kinase activity
GO:0071243--P:cellular response to arsenic-containing substance
GO:0071276--P:cellular response to cadmium ion
GO:0034614--P:cellular response to reactive oxygen species
GO:0042742--P:defense response to bacterium
GO:0050832--P:defense response to fungus
GO:0008340--P:determination of adult lifespan
GO:0003007--P:heart morphogenesis
GO:0006955--P:immune response
GO:0000165--P:MAPK cascade
GO:0002385--P:mucosal immune response
GO:0008348--P:negative regulation of antimicrobial humoral response
GO:0038001--P:paracrine signaling
GO:0045793--P:positive regulation of cell size
GO:0006468--P:protein phosphorylation
GO:0072593--P:reactive oxygen species metabolic process
GO:0048082--P:regulation of adult chitin-containing cuticle pigmentation
GO:1900407--P:regulation of cellular response to oxidative stress
GO:0009408--P:response to heat
GO:0042542--P:response to hydrogen peroxide
GO:0006970--P:response to osmotic stress
GO:0006979--P:response to oxidative stress
GO:0042594--P:response to starvation
|
