| Tag |
Content |
| dbPAF ID |
dbPAF-0002267 |
| Uniprot Accession |
O61661; CHK1_DROME; A4V0S9; Q960N7;
|
| Genbank Protein ID |
NP_477011.1; NP_723985.1; NP_723986.1;
|
| Genbank Nucleotide ID |
NM_057663.4; NM_165171.3; NM_165172.3;
|
| Protein Name |
Serine/threonine-protein kinase grp |
| Protein Synonyms/Alias |
Chk1 homolog;Protein grapes; |
| Gene Name |
grp |
| Gene Synonyms/Alias |
CG17161; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. May phosphorylate the CDC25 phosphatase stg, which promotes its degradation. This results in increased inhibitory tyrosine phosphorylation of Cdk1-cyclin complexes and consequent inhibition of cell cycle progression.Functional Description
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. May phosphorylate the CDC25 phosphatase stg, which promotes its degradation. This results in increased inhibitory tyrosine phosphorylation of Cdk1-cyclin complexes and consequent inhibition of cell cycle progression. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MAATLTEAGT GPAATREFVE GWTLAQTLGE GAYGEVKLLI NRQTGEAVAM KMVDLKKHPD 60
AANSVRKEVC IQKMLQDKHI LRFFGKRSQG SVEYIFLEYA AGGELFDRIE PDVGMPQHEA 120
QRYFTQLLSG LNYLHQRGIA HRDLKPENLL LDEHDNVKIS DFGMATMFRC KGKERLLDKR 180
CGTLPYVAPE VLQKAYHAQP ADLWSCGVIL VTMLAGELPW DQPSTNCTEF TNWRDNDHWQ 240
LQTPWSKLDT LAISLLRKLL ATSPGTRLTL EKTLDHKWCN MQFADNERSY DLVDSAAALE 300
ICSPKAKRQR LQSSAHLSNG LDDSISRNYC SQPMPTMRSD DDFNVRLGSG RSKEDGGDRQ 360
TLAQEARLSY SFSQPALLDD LLLATQMNQT QNASQNYFQR LVRRMTRFFV TTRWDDTIKR 420
LVGTIERLGG YTCKFGDDGV VTVSTVDRNK LRLVFKAHII EMDGKILVDC RLSKGCGLEF 480
KRRFIKIKNA LEDIVLKGPT TWPIAIATNS VP
513Fasta Sequence
>O61661|grp|Drosophila melanogaster(Fruit fly)
MAATLTEAGTGPAATREFVEGWTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPDAANSVRKEVCIQKMLQDKHILRFFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQKAYHAQPADLWSCGVILVTMLAGELPWDQPSTNCTEFTNWRDNDHWQLQTPWSKLDTLAISLLRKLLATSPGTRLTLEKTLDHKWCNMQFADNERSYDLVDSAAALEICSPKAKRQRLQSSAHLSNGLDDSISRNYCSQPMPTMRSDDDFNVRLGSGRSKEDGGDRQTLAQEARLSYSFSQPALLDDLLLATQMNQTQNASQNYFQRLVRRMTRFFVTTRWDDTIKRLVGTIERLGGYTCKFGDDGVVTVSTVDRNKLRLVFKAHIIEMDGKILVDCRLSKGCGLEFKRRFIKIKNALEDIVLKGPTTWPIAIATNSVP
|
| Keyword |
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0227--DNA damage
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
|
| Interpro |
IPR020636--Ca/CaM-dep_Ca-dep_prot_Kinase
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
|
| PROSITE |
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
|
| Pfam |
PF00069--Pkinase
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0007050--P:cell cycle arrest
GO:0000075--P:cell cycle checkpoint
GO:0007349--P:cellularization
GO:0051299--P:centrosome separation
GO:0000077--P:DNA damage checkpoint
GO:0001700--P:embryonic development via the syncytial blastoderm
GO:0016321--P:female meiosis chromosome segregation
GO:0007444--P:imaginal disc development
GO:0007093--P:mitotic cell cycle checkpoint
GO:0033314--P:mitotic DNA replication checkpoint
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0006468--P:protein phosphorylation
GO:0007348--P:regulation of syncytial blastoderm mitotic cell cycle
GO:0009314--P:response to radiation
GO:0051225--P:spindle assembly
GO:0042060--P:wound healing
|
