dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002266
Uniprot Accession O61643; INHB_DROME; Q8MRB1; Q8WR60; Q9V497;
Genbank Protein ID NP_651942.2;
Genbank Nucleotide ID NM_143685.3;
Protein Name Inhibin beta chain
Protein Synonyms/Alias Activin beta chain;dAct;dActivin;
Gene Name Actbeta
Gene Synonyms/Alias activin-beta;CG11062;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
225FSDAKCQSLETNYGTcurated22817900
228AKCQSLETNYGTNYDcurated22817900
Sequence
(Fasta)		MRFAFDSNHS QSGAPFKGSR CFFNCQCICC RQGCCVVVVK CCCCFNLNCC NSLGSRKSFP 60
QPAAMRKKVA DLEVLRVSRF VAVILVLARW VTAVATLLTS CILLDIFSVP GQSGVADRSQ 120
ASSRTVHVSV PTTPNETPSS TSETKLKLLY GYTSYDINND QQVKSNNLCR VLCKSRNRKR 180
QRRRRRRRNH RRRRHRYTKR LHHLMQDNMS GFEQRLNFSD AKCQSLETNY GTNYDLVQGG 240
KLFSQSERSL LVSPLREIEA PWPAIHGSMR NCSKIKRNRA NLIWLLIGLV WFEVKLINCN 300
GISSSNYYAS NLESHKGCTL CHESGKPNIY TDKDNPHTDY NIYNKYHSNN NFNKKTNQPH 360
NNIAPSDEVR LESIKRQILT KLGLSHKPNV SHPLPKQFIW ETIYRVDGGR MIPNNAFGSS 420
GKNLDQKTIK LRAFASPGSH LFNGRGGRTD QRSERDPSHH KYRSPFDFTF NISKNNVYGK 480
VLRNRSLERI DKKNSFLNGW TENRQLKINS QIASMPIELK SHHNSSPKEL KSGAVRKVNG 540
INGTQMNENA LKKSTYPIDI NHSIDNKTHT GKNGEMSHND YEYFNDYSVQ THDKNRYHEG 600
RSSIGYQPAI HNIEYENQKG HHESFADDHE NIDHEDFFGN TQEIITFAEE GTQYRQYRIL 660
EFSAQNRRVP SQKLSIRSAQ IHIRIDKPHS LWIEKAKSLP EKHLLNTKRK WGANKPHHRI 720
KIWVFQLSTS INITEKGIDK AIIFRASFQV DPKNLGWQKF DLTDTIREWY GHTSHEKLRL 780
LIDCTGCGGR YSLHLFQTSK LRGNSSDYLS TNPNRPFLVL HTESSRTRRV RRRAVDCGGA 840
LNGQCCKESF YVSFKALGWD DWIIAPRGYF ANYCRGDCTG SFRTPDTFQT FHAHFIEEYR 900
KMGLMNGMRP CCAPIKFSSM SLIYYGDDGI IKRDLPKMVV DECGCP 947
Keyword

KW-0165--Cleavage on pair of basic residues
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0339--Growth factor
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
Interpro

IPR029034--Cystine-knot_cytokine
IPR002405--Inhibin_asu
IPR001839--TGF-b_C
IPR015615--TGF-beta-rel
IPR017948--TGFb_CS
PROSITE

PS00250--TGF_BETA_1
PS51362--TGF_BETA_2
Pfam

PF00019--TGF_beta
Gene Ontology

GO:0005615--C:extracellular space
GO:0005125--F:cytokine activity
GO:0005160--F:transforming growth factor beta receptor binding
GO:0048468--P:cell development
GO:0016049--P:cell growth
GO:0048813--P:dendrite morphogenesis
GO:0010862--P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0042981--P:regulation of apoptotic process
GO:0043408--P:regulation of MAPK cascade
GO:0060395--P:SMAD protein signal transduction