dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002256
Uniprot Accession O61307; TENM_DROME; A8JNW8; O18366; Q24551; Q9TX59; Q9VNU6;
Genbank Protein ID NP_001097661.2; NP_524215.2;
Genbank Nucleotide ID NM_001104191.3; NM_079491.3;
Protein Name Teneurin-m
Protein Synonyms/Alias
Gene Name Ten-m
Gene Synonyms/Alias odz;CG5723;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with Ten-a to organize neuromuscular synapses. Functions in olfactory synaptic partner matching by promoting homophilic cell adhesion between pre-synaptic olfactory receptor neurons (ORN) axons and post-synaptic projection neurons (PN) dendrites partner in the developing antennal lobe to form stable connections. Also required for peripheral axon growth cone guidance and target recognition of motor neurons.
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
148EPSCLVRTPSGNVYIPHOSIDA;PhosphoPep 2.021081558; 19060867
154RTPSGNVYIPSGNLNPhosphoPep 2.0;SysPTM 2.019060867; 18281928; 19366988
166NLNINKGSPIDFKSGPhosphoPep 2.019060867
2281PRTPHLVTHVHFPKIPHOSIDA21081558
Sequence
(Fasta)		MNPYEYESTL DCRDVGGGPT PAHAHPHAQG RTLPMSGHGR PTTDLGPVHG SQTLQHQNQQ 60
NLQAAQAAAQ SSHYDYEYQH LAHRPPDTAN NTAQRTHGRQ GFLLEGVTPT APPDVPPRNP 120
TMSRMQNGRL TVNNPNDADF EPSCLVRTPS GNVYIPSGNL NINKGSPIDF KSGSACSTPT 180
KDTLKGYERS TQGCMGPVLP QRSVMNGLPA HHYSAPMNFR KDLVARCSSP WFGIGSISVL 240
FAFVVMLILL TTTGVIKWNQ SPPCSVLVGN EASEVTAAKS TNTDLSKLHN SSVRAKNGQG 300
IGLAQGQSGL GAAGVGSGGG SSAATVTTAT SNSGTAQGLQ STSASAEATS SAATSSSQSS 360
LTPSLSSSLA NANNGGARTF PARSFPPDGT TFGQITLGQK LTKEIQPYSY WNMQFYQSEP 420
AYVKFDYTIP RGASIGVYGR RNALPTHTQY HFKEVLSGFS ASTRTARAAH LSITREVTRY 480
MEPGHWFVSL YNDDGDVQEL TFYAAVAEDM TQNCPNGCSG NGQCLLGHCQ CNPGFGGDDC 540
SESVCPVLCS QHGEYTNGEC ICNPGWKGKE CSLRHDECEV ADCSGHGHCV SGKCQCMRGY 600
KGKFCEEVDC PHPNCSGHGF CADGTCICKK GWKGPDCATM DQDALQCLPD CSGHGTFDLD 660
TQTCTCEAKW SGDDCSKELC DLDCGQHGRC EGDACACDPE WGGEYCNTRL CDVRCNEHGQ 720
CKNGTCLCVT GWNGKHCTIE GCPNSCAGHG QCRVSGEGQW ECRCYEGWDG PDCGIALELN 780
CGDSKDNDKD GLVDCEDPEC CASHVCKTSQ LCVSAPKPID VLLRKQPPAI TASFFERMKF 840
LIDESSLQNY AKLETFNESR SAVIRGRVVT SLGMGLVGVR VSTTTLLEGF TLTRDDGWFD 900
LMVNGGGAVT LQFGRAPFRP QSRIVQVPWN EVVIIDLVVM SMSEEKGLAV TTTHTCFAHD 960
YDLMKPVVLA SWKHGFQGAC PDRSAILAES QVIQESLQIP GTGLNLVYHS SRAAGYLSTI 1020
KLQLTPDVIP TSLHLIHLRI TIEGILFERI FEADPGIKFT YAWNRLNIYR QRVYGVTTAV 1080
VKVGYQYTDC TDIVWDIQTT KLSGHDMSIS EVGGWNLDIH HRYNFHEGIL QKGDGSNIYL 1140
RNKPRIILTT MGDGHQRPLE CPDCDGQATK QRLLAPVALA AAPDGSLFVG DFNYIRRIMT 1200
DGSIRTVVKL NATRVSYRYH MALSPLDGTL YVSDPESHQI IRVRDTNDYS QPELNWEAVV 1260
GSGERCLPGD EAHCGDGALA KDAKLAYPKG IAISSDNILY FADGTNIRMV DRDGIVSTLI 1320
GNHMHKSHWK PIPCEGTLKL EEMHLRWPTE LAVSPMDNTL HIIDDHMILR MTPDGRVRVI 1380
SGRPLHCATA STAYDTDLAT HATLVMPQSI AFGPLGELYV AESDSQRINR VRVIGTDGRI 1440
APFAGAESKC NCLERGCDCF EAEHYLATSA KFNTIAALAV TPDSHVHIAD QANYRIRSVM 1500
SSIPEASPSR EYEIYAPDMQ EIYIFNRFGQ HVSTRNILTG ETTYVFTYNV NTSNGKLSTV 1560
TDAAGNKVFL LRDYTSQVNS IENTKGQKCR LRMTRMKMLH ELSTPDNYNV TYEYHGPTGL 1620
LRTKLDSTGR SYVYNYDEFG RLTSAVTPTG RVIELSFDLS VKGAQVKVSE NAQKEMSLLI 1680
QGATVIVRNG AAESRTTVDM DGSTTSITPW GHNLQMEVAP YTILAEQSPL LGESYPVPAK 1740
QRTEIAGDLA NRFEWRYFVR RQQPLQAGKQ SKGPPRPVTE VGRKLRVNGD NVLTLEYDRE 1800
TQSVVVMVDD KQELLNVTYD RTSRPISFRP QSGDYADVDL EYDRFGRLVS WKWGVLQEAY 1860
SFDRNGRLNE IKYGDGSTMV YAFKDMFGSL PLKVTTPRRS DYLLQYDDAG ALQSLTTPRG 1920
HIHAFSLQTS LGFFKYQYYS PINRHPFEIL YNDEGQILAK IHPHQSGKVA FVHDTAGRLE 1980
TILAGLSSTH YTYQDTTSLV KSVEVQEPGF ELRREFKYHA GILKDEKLRF GSKNSLASAR 2040
YKYAYDGNAR LSGIEMAIDD KELPTTRYKY SQNLGQLEVV QDLKITRNAF NRTVIQDSAK 2100
QFFAIVDYDQ HGRVKSVLMN VKNIDVFRLE LDYDLRNRIK SQKTTFGRST AFDKINYNAD 2160
GHVVEVLGTN NWKYLFDENG NTVGVVDQGE KFNLGYDIGD RVIKVGDVEF NNYDARGFVV 2220
KRGEQKYRYN NRGQLIHSFE RERFQSWYYY DDRSRLVAWH DNKGNTTQYY YANPRTPHLV 2280
THVHFPKISR TMKLFYDDRD MLIALEHEDQ RYYVATDQNG SPLAFFDQNG SIVKEMKRTP 2340
FGRIIKDTKP EFFVPIDFHG GLIDPHTKLV YTEQRQYDPH VGQWMTPLWE TLATEMSHPT 2400
DVFIYRYHNN DPINPNKPQN YMIDLDSWLQ LFGYDLNNMQ SSRYTKLAQY TPQASIKSNT 2460
LAPDFGVISG LECIVEKTSE KFSDFDFVPK PLLKMEPKMR NLLPRVSYRR GVFGEGVLLS 2520
RIGGRALVSV VDGSNSVVQD VVSSVFNNSY FLDLHFSIHD QDVFYFVKDN VLKLRDDNEE 2580
LRRLGGMFNI STHEISDHGG SAAKELRLHG PDAVVIIKYG VDPEQERHRI LKHAHKRAVE 2640
RAWELEKQLV AAGFQGRGDW TEEEKEELVQ HGDVDGWNGI DIHSIHKYPQ LADDPGNVAF 2700
QRDAKRKRRK TGSSHRSASN RRQLKFGELS A 2732
Keyword

KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0771--Synaptosome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR008969--CarboxyPept-like_regulatory
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR031325--RHS_repeat
IPR028916--Tox-GHH_dom
IPR006530--YD
PROSITE

PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
Pfam

PF05593--RHS_repeat
PF15636--Tox-GHH
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005887--C:integral component of plasma membrane
GO:0031594--C:neuromuscular junction
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0045211--C:postsynaptic membrane
GO:0005578--C:proteinaceous extracellular matrix
GO:0031005--F:filamin binding
GO:0042802--F:identical protein binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0007155--P:cell adhesion
GO:0022416--P:chaeta development
GO:0048058--P:compound eye corneal lens development
GO:0001745--P:compound eye morphogenesis
GO:0042051--P:compound eye photoreceptor development
GO:0031122--P:cytoplasmic microtubule organization
GO:0048790--P:maintenance of presynaptic active zone structure
GO:0008045--P:motor neuron axon guidance
GO:0007274--P:neuromuscular synaptic transmission
GO:0034116--P:positive regulation of heterotypic cell-cell adhesion
GO:0040017--P:positive regulation of locomotion
GO:0001941--P:postsynaptic membrane organization
GO:0097090--P:presynaptic membrane organization
GO:0045467--P:R7 cell development
GO:0008360--P:regulation of cell shape
GO:0034110--P:regulation of homotypic cell-cell adhesion
GO:2000331--P:regulation of terminal button organization
GO:0050808--P:synapse organization
GO:0051124--P:synaptic growth at neuromuscular junction
GO:0016200--P:synaptic target attraction
GO:0008039--P:synaptic target recognition
GO:0048499--P:synaptic vesicle membrane organization