dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002048
Uniprot Accession O60231; DHX16_HUMAN; O60322; Q5JP45; Q969X7; Q96QC1;
Genbank Protein ID NP_001157711.1; NP_003578.2;
Genbank Nucleotide ID NM_001164239.1; NM_003587.4;
Protein Name Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Protein Synonyms/Alias ATP-dependent RNA helicase #3;DEAH-box protein 16;
Gene Name DHX16
Gene Synonyms/Alias DBP2;DDX16;KIAA0577;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Probable ATP-binding RNA helicase involved in pre-mRNA splicing.
Phosphorylation Sites
 dbPAF PTMs: 19
PositionPeptidesSourceReferences ( PMIDs )
3-----MATPAGLERWcurated22199227
103SYRLLEDSEESSEETdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated15302935; 17081983; 18187866; 18318008; 18669648; 19413330;
106LLEDSEESSEETVSRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18187866; 18669648; 19413330; 16381945; 23193290;
107LEDSEESSEETVSRAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18318008; 18669648; 19413330; 16381945; 23193290;
110SEESSEETVSRAGSScurated23090842
112ESSEETVSRAGSSLQPhosphoSitePlus22135298
116ETVSRAGSSLQKKRKdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
117TVSRAGSSLQKKRKKcurated23090842; 20068231
141EEEEEEASEKGKKKTdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
155TGGSKQQTEKPESEDdbPTM 3.0;HPRD 9;curated18452278; 16381945; 23193290; 18988627; 25850435; 22817900
160QQTEKPESEDEWERTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 20068231; 20164059; 20363803;
167SEDEWERTERERLQDcurated23186163
205ERSDKKAYEEAQKRLPhosphoSitePlus22135298
338EARLGAASLKFGARDPhosphoSitePlus;curated22135298; 23186163
348FGARDAASQEPKYQLPhosphoSitePlus;curated22135298; 25627689
552ELKVLVASATMDTARdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
554KVLVASATMDTARFSdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
663QARIFQPTPPGARKVPhosphoSitePlus22135298
712GMESLTVTPCSKASAPhosphoSitePlus;curated22135298; 25627689; 23917254
Sequence
(Fasta)		MATPAGLERW VQDELHSVLG LSERHVAQFL IGTAQRCTSA EEFVQRLRDT DTLDLSGPAR 60
DFALRLWNKV PRKAVVEKPA RAAEREARAL LEKNRSYRLL EDSEESSEET VSRAGSSLQK 120
KRKKRKHLRK KREEEEEEEA SEKGKKKTGG SKQQTEKPES EDEWERTERE RLQDLEERDA 180
FAERVRQRDK DRTRNVLERS DKKAYEEAQK RLKMAEEDRK AMVPELRKKS RREYLAKRER 240
EKLEDLEAEL ADEEFLFGDV ELSRHERQEL KYKRRVRDLA REYRAAGEQE KLEATNRYHM 300
PKETRGQPAR AVDLVEEESG APGEEQRRWE EARLGAASLK FGARDAASQE PKYQLVLEEE 360
ETIEFVRATQ LQGDEEPSAP PTSTQAQQKE SIQAVRRSLP VFPFREELLA AIANHQVLII 420
EGETGSGKTT QIPQYLFEEG YTNKGMKIAC TQPRRVAAMS VAARVAREMG VKLGNEVGYS 480
IRFEDCTSER TVLRYMTDGM LLREFLSEPD LASYSVVMVD EAHERTLHTD ILFGLIKDVA 540
RFRPELKVLV ASATMDTARF STFFDDAPVF RIPGRRFPVD IFYTKAPEAD YLEACVVSVL 600
QIHVTQPPGD ILVFLTGQEE IEAACEMLQD RCRRLGSKIR ELLVLPIYAN LPSDMQARIF 660
QPTPPGARKV VVATNIAETS LTIEGIIYVL DPGFCKQKSY NPRTGMESLT VTPCSKASAN 720
QRAGRAGRVA AGKCFRLYTA WAYQHELEET TVPEIQRTSL GNVVLLLKSL GIHDLMHFDF 780
LDPPPYETLL LALEQLYALG ALNHLGELTT SGRKMAELPV DPMLSKMILA SEKYSCSEEI 840
LTVAAMLSVN NSIFYRPKDK VVHADNARVN FFLPGGDHLV LLNVYTQWAE SGYSSQWCYE 900
NFVQFRSMRR ARDVREQLEG LLERVEVGLS SCQGDYIRVR KAITAGYFYH TARLTRSGYR 960
TVKQQQTVFI HPNSSLFEQQ PRWLLYHELV LTTKEFMRQV LEIESSWLLE VAPHYYKAKE 1020
LEDPHAKKMP KKIGKTREEL G 1042
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0347--Helicase
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR011545--DEAD/DEAH_box_helicase_dom
IPR002464--DNA/RNA_helicase_DEAH_CS
IPR011709--DUF1605
IPR007502--Helicase-assoc_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
PROSITE

PS00690--DEAH_ATP_HELICASE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
Pfam

PF00270--DEAD
PF04408--HA2
PF00271--Helicase_C
PF07717--OB_NTP_bind
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0005524--F:ATP binding
GO:0004004--F:ATP-dependent RNA helicase activity
GO:0044822--F:poly(A) RNA binding
GO:0003724--F:RNA helicase activity
GO:0006397--P:mRNA processing
GO:0008380--P:RNA splicing