dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002047
Uniprot Accession O60229; KALRN_HUMAN; A8MSI4; C9JQ37; Q6ZN45; Q8TBQ5; Q9NSZ4; Q9Y2A5;
Genbank Protein ID NP_001019831.2; NP_003938.1; NP_008995.2;
Genbank Nucleotide ID NM_001024660.3; NM_003947.4; NM_007064.3;
Protein Name Kalirin
Protein Synonyms/Alias Huntingtin-associated protein-interacting protein;Protein Duo;Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain;
Gene Name KALRN
Gene Synonyms/Alias DUET;DUO;HAPIP;TRAD;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Phosphorylation Sites
 dbPAF PTMs: 32 (View all)
PositionPeptidesSourceReferences ( PMIDs )
86TYLASVPSEDVCKRGPhosphoSitePlus22135298
103VIIDMRGSKWDLIKPPhosphoSitePlus22135298
223FPVDVEGSRRLIDEHPhosphoSitePlus22135298
487DVLQRPLSPGNSESLdbPTM 3.0;PhosphoSitePlus22508986; 16381945; 23193290; 22135298
672LEDVCADSVDAVQELPhosphoSitePlus;curated22135298; 25627689
1079NAEVFLKYIHRNNVSPhosphoSitePlus22135298
1256ELDIIPASLSDREVKPhosphoSitePlus22135298
1607PAKQRNNSKRDGVEDPhosphoSitePlus22135298
1714CISHSRSSVEMDCFFcurated25850435
1750ANLQAQPSLNSIHSSdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18088087; 16381945; 23193290; 22135298; 19366988; 23898821;
1753QAQPSLNSIHSSPGPdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18088087; 16381945; 23193290; 18669648; 18988627; 22135298;
1756PSLNSIHSSPGPKRSdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18088087; 16381945; 23193290; 18669648; 18988627; 22135298;
1757SLNSIHSSPGPKRSTdbPTM 3.0;HPRD 9;curated18669648; 16381945; 23193290; 18988627; 23898821; 22817900;
1763SSPGPKRSTNTLKKWPhosphoSitePlus22135298
1772NTLKKWLTSPVRRLNcurated23898821
1773TLKKWLTSPVRRLNSdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated16964243; 16381945; 23193290; 18220336; 19276368; 19664994;
1780SPVRRLNSGKADGNIPhosphoSitePlus;curated22135298; 25849741
1799KVRDGRKSFDLGSPKdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18088087; 18669648; 16381945; 23193290; 20058876; 18988627;
1804RKSFDLGSPKPGDETcurated25849741
1817ETTPQGDSADEKSKKdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18088087; 16381945; 23193290; 22135298; 19366988; 22817900
Sequence
(Fasta)		MTDRFWDQWY LWYLRLLRLL DRGSFRNDGL KASDVLPILK EKVAFVSGGR DKRGGPILTF 60
PARSNHDRIR QEDLRKLVTY LASVPSEDVC KRGFTVIIDM RGSKWDLIKP LLKTLQEAFP 120
AEIHVALIIK PDNFWQKQKT NFGSSKFIFE TSMVSVEGLT KLVDPSQLTE EFDGSLDYNH 180
EEWIELRLSL EEFFNSAVHL LSRLEDLQEM LARKEFPVDV EGSRRLIDEH TQLKKKVLKA 240
PVEELDREGQ RLLQCIRCSD GFSGRNCIPG SADFQSLVPK ITSLLDKLHS TRQHLHQMWH 300
VRKLKLDQCF QLRLFEQDAE KMFDWISHNK ELFLQSHTEI GVSYQYALDL QTQHNHFAMN 360
SMNAYVNINR IMSVASRLSE AGHYASQQIK QISTQLDQEW KSFAAALDER STILAMSAVF 420
HQKAEQFLSG VDAWCKMCSE GGLPSEMQDL ELAIHHHQTL YEQVTQAYTE VSQDGKALLD 480
VLQRPLSPGN SESLTATANY SKAVHQVLDV VHEVLHHQRR LESIWQHRKV RLHQRLQLCV 540
FQQDVQQVLD WIENHGEAFL SKHTGVGKSL HRARALQKRH DDFEEVAQNT YTNADKLLEA 600
AEQLAQTGEC DPEEIYKAAR HLEVRIQDFV RRVEQRKLLL DMSVSFHTHT KELWTWMEDL 660
QKEMLEDVCA DSVDAVQELI KQFQQQQTAT LDATLNVIKE GEDLIQQLRS APPSLGEPSE 720
ARDSAVSNNK TPHSSSISHI ESVLQQLDDA QVQMEELFHE RKIKLDIFLQ LRIFEQYTIE 780
VTAELDAWNE DLLRQMNDFN TEDLTLAEQR LQRHTERKLA MNNMTFEVIQ QGQDLHQYIT 840
EVQASGIELI CEKDIDLAAQ VQELLEFLHE KQHELELNAE QTHKRLEQCL QLRHLQAEVK 900
QVLGWIRNGE SMLNASLVNA SSLSEAEQLQ REHEQFQLAI ESLFHATSLQ KTHQSALQVQ 960
QKAEVLLQAG HYDADAIREC AEKVALHWQQ LMLKMEDRLK LVNASVAFYK TSEQVCSVLE 1020
SLEQEYRRDE DWCGGRDKLG PAAEIDHVIP LISKHLEQKE AFLKACTLAR RNAEVFLKYI 1080
HRNNVSMPSV ASHTRGPEQQ VKAILSELLQ RENRVLHFWT LKKRRLDQCQ QYVVFERSAK 1140
QALDWIQETG EFYLSTHTST GETTEETQEL LKEYGEFRVP AKQTKEKVKL LIQLADSFVE 1200
KGHIHATEIR KWVTTVDKHY RDFSLRMGKY RYSLEKALGV NTEDNKDLEL DIIPASLSDR 1260
EVKLRDANHE VNEEKRKSAR KKEFIMAELL QTEKAYVRDL HECLETYLWE MTSGVEEIPP 1320
GILNKEHIIF GNIQEIYDFH NNIFLKELEK YEQLPEDVGH CFVTWADKFQ MYVTYCKNKP 1380
DSNQLILEHA GTFFDEIQQR HGLANSISSY LIKPVQRITK YQLLLKELLT CCEEGKGELK 1440
DGLEVMLSVP KKANDAMHVS MLEGFDENLD VQGELILQDA FQVWDPKSLI RKGRERHLFL 1500
FEISLVFSKE IKDSSGHTKY VYKNKLLTSE LGVTEHVEGD PCKFALWSGR TPSSDNKTVL 1560
KASNIETKQE WIKNIREVIQ ERIIHLKGAL KEPLQLPKTP AKQRNNSKRD GVEDIDSQGD 1620
GSSQPDTISI ASRTSQNTVD SDKLSGGCEL TVVLQDFSAG HSSELTIQVG QTVELLERPS 1680
ERPGWCLVRT TERSPPLEGL VPSSALCISH SRSSVEMDCF FPLVKDAYSH SSSENGGKSE 1740
SVANLQAQPS LNSIHSSPGP KRSTNTLKKW LTSPVRRLNS GKADGNIKKQ KKVRDGRKSF 1800
DLGSPKPGDE TTPQGDSADE KSKKGWGEDE PDEESHTPLP PPMKIFDNDP TQDEMSSLLA 1860
ARQASTEVPT AADLVNAIEK LVKNKLSLEG SSYRGSLKDP AGCLNEGMAP PTPPKNPEEE 1920
QKAKALRGRM FVLNELVQTE KDYVKDLGIV VEGFMKRIEE KGVPEDMRGK DKIVFGNIHQ 1980
IYDWHKDFFL AELEKCIQEQ DRLAQLFIKH ERKLHIYVWY CQNKPRSEYI VAEYDAYFEE 2040
VKQEINQRLT LSDFLIKPIQ RITKYQLLLK DFLRYSEKAG LECSDIEKAV ELMCLVPKRC 2100
NDMMNLGRLQ GFEGTLTAQG KLLQQDTFYV IELDAGMQSR TKERRVFLFE QIVIFSELLR 2160
KGSLTPGYMF KRSIKMNYLV LEENVDNDPC KFALMNRETS ERVVLQAANA DIQQAWVQDI 2220
NQVLETQRDF LNALQSPIEY QRKERSTAVM RSQPARLPQA SPRPYSSVPA GSEKPPKGSS 2280
YNPPLPPLKI STSNGSPGFE YHQPGDKFEA SKQNDLGGCN GTSSMAVIKD YYALKENEIC 2340
VSQGEVVQVL AVNQQNMCLV YQPASDHSPA AEGWVPGSIL APLTKATAAE SSDGSIKKSC 2400
SWHTLRMRKR AEVENTGKNE ATGPRKPKDI LGNKVSVKET NSSEESECDD LDPNTSMEIL 2460
NPNFIQEVAP EFLVPLVDVT CLLGDTVILQ CKVCGRPKPT ITWKGPDQNI LDTDNSSATY 2520
TVSSCDSGEI TLKICNLMPQ DSGIYTCIAT NDHGTTSTSA TVKVQGVPAA PNRPIAQERS 2580
CTSVILRWLP PSSTGNCTIS GYTVEYREEG SQIWQQSVAS TLDTYLVIED LSPGCPYQFR 2640
VSASNPWGIS LPSEPSEFVR LPEYDAAADG ATISWKENFD SAYTELNEIG RGRFSIVKKC 2700
IHKATRKDVA VKFVSKKMKK KEQAAHEAAL LQHLQHPQYI TLHDTYESPT SYILILELMD 2760
DGRLLDYLMN HDELMEEKVA FYIRDIMEAL QYLHNCRVAH LDIKPENLLI DLRIPVPRVK 2820
LIDLEDAVQI SGHFHIHHLL GNPEFAAPEV IQGIPVSLGT DIWSIGVLTY VMLSGVSPFL 2880
DESKEETCIN VCRVDFSFPH EYFCGVSNAA RDFINVILQE DFRRRPTAAT CLQHPWLQPH 2940
NGSYSKIPLD TSRLACFIER RKHQNDVRPI PNVKSYIVNR VNQGT 2986
Keyword

KW-0024--Alternative initiation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1015--Disulfide bond
KW-0344--Guanine-nucleotide releasing factor
KW-0393--Immunoglobulin domain
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase
Interpro

IPR001251--CRAL-TRIO_dom
IPR000219--DH-domain
IPR003961--FN3_dom
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR013098--Ig_I-set
IPR003598--Ig_sub2
IPR028569--Kalirin
IPR011009--Kinase-like_dom
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain
IPR018159--Spectrin/alpha-actinin
IPR002017--Spectrin_repeat
PROSITE

PS50191--CRAL_TRIO
PS50010--DH_2
PS50853--FN3
PS50835--IG_LIKE
PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3
Pfam

PF13716--CRAL_TRIO_2
PF00041--fn3
PF07679--I-set
PF00169--PH
PF00069--Pkinase
PF00621--RhoGEF
PF00435--Spectrin
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005524--F:ATP binding
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0046872--F:metal ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0097190--P:apoptotic signaling pathway
GO:0007411--P:axon guidance
GO:0048013--P:ephrin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0007399--P:nervous system development
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0043547--P:positive regulation of GTPase activity
GO:0006468--P:protein phosphorylation
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007165--P:signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0016192--P:vesicle-mediated transport