dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0002043
Uniprot Accession O60218; AK1BA_HUMAN; A4D1P1; O75890; Q6FHF3; Q8IWZ1;
Genbank Protein ID NP_064695.3;
Genbank Nucleotide ID NM_020299.4;
Protein Name Aldo-keto reductase family 1 member B10
Protein Synonyms/Alias ARL-1;Aldose reductase-like;Aldose reductase-related protein;ARP;hARP;Small intestine reductase;SI reductase;
Gene Name AKR1B10
Gene Synonyms/Alias AKR1B11;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
23VGLGTWKSPLGKVKEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19415658; 16381945; 23193290; 18988627; 22135298; 22817900;
40KVAIDAGYRHIDCAYPhosphoSitePlus22135298
47YRHIDCAYVYQNEHEdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 19060867; 22135298; 22817900
49HIDCAYVYQNEHEVGPhosphoSitePlus22135298
288LSDEEMATILSFNRNdbPTM 3.020068231; 16381945; 23193290
291EEMATILSFNRNWRAdbPTM 3.0;HPRD 920068231; 16381945; 23193290; 18988627
310QSSHLEDYPFNAEY-PhosphoSitePlus22135298
316DYPFNAEY-------dbPTM 3.0;PhosphoSitePlus18083107; 16381945; 23193290; 22135298
Sequence
(Fasta)		MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ 60
EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD 120
DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP 180
VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK 240
HKKTAAQVLI RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN 300
VLQSSHLEDY PFNAEY 317
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0458--Lysosome
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
Interpro

IPR001395--Aldo/ket_red/Kv-b
IPR018170--Aldo/ket_reductase_CS
IPR020471--Aldo/keto_reductase
IPR023210--NADP_OxRdtase_dom
PROSITE

PS00798--ALDOKETO_REDUCTASE_1
PS00062--ALDOKETO_REDUCTASE_2
PS00063--ALDOKETO_REDUCTASE_3
Pfam

PF00248--Aldo_ket_red
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005764--C:lysosome
GO:0004033--F:aldo-keto reductase (NADP) activity
GO:0045550--F:geranylgeranyl reductase activity
GO:0047718--F:indanol dehydrogenase activity
GO:0001758--F:retinal dehydrogenase activity
GO:0006081--P:cellular aldehyde metabolic process
GO:0044597--P:daunorubicin metabolic process
GO:0007586--P:digestion
GO:0044598--P:doxorubicin metabolic process
GO:0016488--P:farnesol catabolic process
GO:0007603--P:phototransduction, visible light
GO:0001523--P:retinoid metabolic process
GO:0008202--P:steroid metabolic process