| Tag |
Content |
| dbPAF ID |
dbPAF-0001956 |
| Uniprot Accession |
O55207; SYNJ2_RAT; Q91ZD8; Q91ZD9;
|
| Genbank Protein ID |
NP_001106842.1; NP_001106843.1; NP_114460.1;
|
| Genbank Nucleotide ID |
NM_001113371.1; NM_001113372.1; NM_032071.2;
|
| Protein Name |
Synaptojanin-2 |
| Protein Synonyms/Alias |
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2; |
| Gene Name |
Synj2 |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis (By similarity).Functional Description
Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MALSKGLRLL ARLDPTGPSS VLLEARGRGD CLLFEAGAVA TLAPEEKEVI KGLYGKPTDA 60
YGCLGELSLK SGGVPLSFLV LVTGCTSVGR IPDAEIYKIT GTEFYPLQEE AKEEDRLPAL 120
KKILSSGVFY FAWPNDGACF DLTIRAQKQG DDCSEWGTSF FWNQLLHVPL RQHQVNCHDW 180
LLKVICGVVT IRTVYASHKQ AKACLISRIS CERAGARFLT RGVNDDGHVS NFVETEQAIY 240
MDDGVSSFVQ IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFERHMVL LKEQYGQQVV 300
VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGRKLEKLE NLLRPQLKLH 360
WDDFGVFAKG ENVSPRFQKG TLRMNCLDCL DRTNTVQCFI ALEVLHLQLE SLGLNSKPIT 420
DRFVESFKAM WSLNGHGLSK VFTGSRALEG KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA 480
IKLLLVGDVY NEESTDKGRM LLDNTALLGL GSNKQNSLSG MLDGKATPRI LKAMTERQSE 540
FTNFKRIQIA MGTWNVNGGK QFRSNLLGTT ELTDWLLDAP QLSGAVDSQD DGGPADIFAV 600
GFEEMVELSA GNIVNASTTN RKMWGEQLQK AISRSHRYIL LTSAQLVGVC LYIFVRPYHV 660
PFIRDVAIDT VKTGMGGKAG NKGAVGIRFQ FHSTSFCFIC SHLTAGQSQV KERNEDYREI 720
THKLSFPSGR NIFSHDYVFW CGDFNYRIDL TYEEVFYFVK RQDWKKLMEF DQLQLQKSSG 780
KIFKDFHEGT INFGPTYKYD VGSAAYDTSD KCRTPAWTDR VLWWRKKHPY DKTAGELNLL 840
DSDLDGDANI RHTWSPGTLK YYGRAELQAS DHRPVLAIVE VEVQEVDVGA RERVFQEVSS 900
VQGPLDATVI VNLQSPTLEE RNEFPEDLRT ELMQTLGNYG TIILVRINQG QMLVTFADSH 960
SALSVLDVDG MKVKGRAVKI RPKTKDWLEG LREELIRKRD SMAPVSPTAN SCLLEENFDF 1020
TSLDYESEGD VLEDDEDYLA DEFGQPVVSD SELGGDDSSD TMSASTPASK SPALAKKKQH 1080
PTYKDDADLM TLKLELEVAG NFRHRSPSRS LSVPNRPRPP HPPQRPPPPT GLMVKKSASD 1140
ASISSGTHGQ YSILQTAKLL PGAPQQPPKA RTGISKPYNV KQIKTTNAQE AEAAIRCLLE 1200
AGGGVPESAP GATPLRNQGS SKPEASLGPP VLPRRPVPRV PTMKKPTLRR TGKPMLPEEQ 1260
CEQQPVHFTM ASQEMNLETP PPITAPIPPV PKPRTFQPGR GVERRPSGGK PEPDDAPPVT 1320
GAVELSSPEA PEAPSLAPKV PPRRKKSAPA AFHLQVLQSN SQLLQGLTCS SSSPSPPKPD 1380
TPLLYPQMAL GTSSAISPET DGPRVTEPEA ASFHGDYPDP FWSLLHHPKL LNNNTWLSKS 1440
SEPLDLGSRT PERTHTDSAQ VNASVVERGL PPDHGGKDFS HWMAASNKDK RTTLGV
1497Fasta Sequence
>O55207|Synj2|Rattus norvegicus(Rat)
MALSKGLRLLARLDPTGPSSVLLEARGRGDCLLFEAGAVATLAPEEKEVIKGLYGKPTDAYGCLGELSLKSGGVPLSFLVLVTGCTSVGRIPDAEIYKITGTEFYPLQEEAKEEDRLPALKKILSSGVFYFAWPNDGACFDLTIRAQKQGDDCSEWGTSFFWNQLLHVPLRQHQVNCHDWLLKVICGVVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQAIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKLENLLRPQLKLHWDDFGVFAKGENVSPRFQKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGLNSKPITDRFVESFKAMWSLNGHGLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTALLGLGSNKQNSLSGMLDGKATPRILKAMTERQSEFTNFKRIQIAMGTWNVNGGKQFRSNLLGTTELTDWLLDAPQLSGAVDSQDDGGPADIFAVGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLMEFDQLQLQKSSGKIFKDFHEGTINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLDSDLDGDANIRHTWSPGTLKYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSVQGPLDATVIVNLQSPTLEERNEFPEDLRTELMQTLGNYGTIILVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLEGLREELIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDVLEDDEDYLADEFGQPVVSDSELGGDDSSDTMSASTPASKSPALAKKKQHPTYKDDADLMTLKLELEVAGNFRHRSPSRSLSVPNRPRPPHPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTAKLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEAGGGVPESAPGATPLRNQGSSKPEASLGPPVLPRRPVPRVPTMKKPTLRRTGKPMLPEEQCEQQPVHFTMASQEMNLETPPPITAPIPPVPKPRTFQPGRGVERRPSGGKPEPDDAPPVTGAVELSSPEAPEAPSLAPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTCSSSSPSPPKPDTPLLYPQMALGTSSAISPETDGPRVTEPEAASFHGDYPDPFWSLLHHPKLLNNNTWLSKSSEPLDLGSRTPERTHTDSAQVNASVVERGLPPDHGGKDFSHWMAASNKDKRTTLGV
|
| Keyword |
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0694--RNA-binding
|
| Interpro |
IPR015047--DUF1866
IPR005135--Endo/exonuclease/phosphatase
IPR000300--IPPc
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR002013--SAC_dom
|
| PROSITE |
PS50102--RRM
PS50275--SAC
|
| Pfam |
PF08952--DUF1866
PF03372--Exo_endo_phos
PF02383--Syja_N
|
| Gene Ontology |
GO:0043679--C:axon terminus
GO:0005737--C:cytoplasm
GO:0005881--C:cytoplasmic microtubule
GO:0031315--C:extrinsic component of mitochondrial outer membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0032587--C:ruffle membrane
GO:0004445--F:inositol-polyphosphate 5-phosphatase activity
GO:0000166--F:nucleotide binding
GO:0030165--F:PDZ domain binding
GO:0052744--F:phosphatidylinositol monophosphate phosphatase activity
GO:0004439--F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0003723--F:RNA binding
GO:0017124--F:SH3 domain binding
GO:0007420--P:brain development
GO:0046855--P:inositol phosphate dephosphorylation
GO:0048312--P:intracellular distribution of mitochondria
GO:0046856--P:phosphatidylinositol dephosphorylation
|
