dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0001946 | ||||||||||||
| Uniprot Accession | O55166; VPS52_RAT; | ||||||||||||
| Genbank Protein ID | NP_149088.1; | ||||||||||||
| Genbank Nucleotide ID | NM_033097.2; | ||||||||||||
| Protein Name | Vacuolar protein sorting-associated protein 52 homolog | ||||||||||||
| Protein Synonyms/Alias | SAC2 suppressor of actin mutations 2-like protein; | ||||||||||||
| Gene Name | Vps52 | ||||||||||||
| Gene Synonyms/Alias | Are1;Sacm2l; | ||||||||||||
| Organism | Rattus norvegicus(Rat) | ||||||||||||
| NCBI Taxa ID | 10116 | ||||||||||||
| Functional Description (View all) |
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MAAAATMAAA ARELVLRAGA SDMEEEEGPL GAGSGLQEPL QLGELDITSD EFILDEVDVH 60 IQANLEDELV KEALKTGVDL RHYSKQVELE LQQIEQKSIR DYIQESENIA SLHNQITACD 120 AVLERMEQML GAFQSDLSSI SCEIRTLQEQ SGAMNIRLRN RQAVRGKLGE LVDGLVVPSA 180 LVTAILEAPV TEPRFLEQLQ ELDAKAAAVR EQEARGTAAC ADVRGVLDRL RVKAVTKIRE 240 FILQKIYSFR KPMTNYQIPQ TALLKYRFFY QFLLGNERAT AKEVRDEYVE TLSKIYLSYY 300 RSYVGRLMKV QYEEVAEKDD LMGVEDTAKK GFFSKPSLRS RNTIFTLGTR GAVISPAELE 360 APILVPHTAQ RGEQRYPFEA LFRSQHYALL DNSCREYLFI CEFFVVSGPA AHDLFHAVMG 420 RTLSMTLKHL ESYLADCYDA IAVFLCIHIV LRFRNIAAKR DVPALDRYWE QVLALLWPRF 480 ELILEMNVQS VRSTDPQRLG GLDTRPHYIT RRYAEFSSAL VSINQTIPNE RTLQLLGQLQ 540 VEVENFVLRV AAEFSSRKEQ LVFLINNYDM MLGVLMERAA DDSKEVESFQ QLLNARTQEF 600 IEELLSPPFG GLVAFVKEAE ALIERGQAER LRGEEARVTQ LIRGFGSSWK ASVESLSQDV 660 MRSFTNFRNG TSIIQGALTQ LIQLYHRFHR VLSQPQLRAL PARAELINIH HLMVELKKHK 720 PNF 724 |
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| Keyword | KW-0007--Acetylation |
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| Interpro | IPR007258--Vps52 |
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| PROSITE | |||||||||||||
| Pfam | PF04129--Vps52 |
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| Gene Ontology | GO:1990745--C:EARP complex |