dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001944
Uniprot Accession O55164; MPDZ_RAT;
Genbank Protein ID NP_062069.1;
Genbank Nucleotide ID NM_019196.1;
Protein Name Multiple PDZ domain protein
Protein Synonyms/Alias Multi-PDZ domain protein 1;
Gene Name Mpdz
Gene Synonyms/Alias Mupp1;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
230RGSLPHISSPRISRScurated23984901
231GSLPHISSPRISRSPcurated23712012; 21630457
465TLMRKGASQEAEITSPhosphoSitePlus;curated22135298; 23712012; 21630457
495EKDEESLSLKRSTSIPhosphoSitePlus22135298
782VAKPLPLSPEEGYVSPhosphoSitePlus22135298
907LQRQHAGSPPTDMSPcurated23712012; 21630457
913GSPPTDMSPAATSGFcurated23712012; 21630457
917TDMSPAATSGFTVSDcurated23712012; 21630457
1065RAMLRRHSLIGPDIKcurated23984901
1455EVEPSITTSASAVDLcurated23984901
1802FHSERRPSQSSQVSEPhosphoSitePlus22135298
1804SERRPSQSSQVSESSPhosphoSitePlus22135298
1805ERRPSQSSQVSESSLPhosphoSitePlus22135298
1808PSQSSQVSESSLSSFPhosphoSitePlus;UniProt22135298; 22673903
1811SSQVSESSLSSFSLPPhosphoSitePlus22135298
Sequence
(Fasta)		MLETIDKNRA LQAAERLQSK LKERGDVANE DKLSLLKSVL QSPLFSQILS LQTSLQQLKD 60
QVNVATLATA NADHAHTPQF SSAIISNLQS ESLLLSPSNG NLEAISGPGA PPAMDGKPAC 120
EELDQLIKSM AQGRHVEIFE LLKPPCGGLG FSVVGLRSEN RGELGIFVQE IQEGSVAHRD 180
GRLKETDQIL AINGQVLDQT ITHQQAISIL QKAKDTIQLV IARGSLPHIS SPRISRSPSA 240
ASTVSAHSNP THWQHVETIE LVNDGSGLGF GIIGGKATGV IVKTILPGGV ADQHGRLCSG 300
DHILKIGDTD LAGMSSEQVA QVLRQCGNRV KLMIARGAVE ETPAPSSLGI TLSSSTSTSE 360
MRVDASTQKN EESETFDVEL TKNVQGLGIT IAGYIGDKKL EPSGIFVKSI TKSSAVELDG 420
RIQIGDQIVA VDGTNLQGFT NQQAVEVLRH TGQTVRLTLM RKGASQEAEI TSREDTAKDV 480
DLPAENYEKD EESLSLKRST SILPIEEEGY PLLSTELEET EDVQQEAALL TKWQRIMGIN 540
YEIVVAHVSK FSENSGLGIS LEATVGHHFI RSVLPEGPVG HSGKLFSGDE LLEVNGINLL 600
GENHQDVVNI LKELPIDVTM VCCRRTVPPT ALSEVDSLDI HDLELTEKPH IDLGEFIGSS 660
ETEDPMLAMS DVDQNAEEIQ TPLAMWEAGI QAIELEKGSR GLGFSILDYQ DPIDPANTVI 720
VIRSLVPGGI AEKDGRLFPG DRLMFVNDIN LENSTLEEAV EALKGAPSGM VRIGVAKPLP 780
LSPEEGYVSA KEDTFLCSPH TCKEMGLSDK ALFRADLALI DTPDAESVAE SRFESQFSPD 840
NDSVYSTQAS VLSLHDGACS DGMNYGPSLP SSPPKDVTNS SDLVLGLHLS LEELYTQNLL 900
QRQHAGSPPT DMSPAATSGF TVSDYTPANA VEQKYECANT VAWTPSQLPS GLSTTELAPA 960
LPAVAPKYLT EQSSLVSDAE SVTLQSMSQE AFERTVTIAK GSSSLGMTVS ANKDGLGVIV 1020
RSIIHGGAIS RDGRIAVGDC ILSINEESTI SLTNAQARAM LRRHSLIGPD IKITYVPAEH 1080
LEEFRVSFGQ QAGGIMALDI FSSYTGRDIP ELPEREEGEG EESELQNAAY SSWSQPRRVE 1140
LWREPSKSLG ISIVGGRGMG SRLSNGEVMR GIFIKHVLED SPAGKNGTLK PGDRIVEVDG 1200
MDLRDASHEQ AVEAIRKAGS PVVFMVQSIV NRPRKSPLPS LPHSLYPKCS FSSTNPFAES 1260
LQLTSDKAPS QSESESEKAT LCSVPSSSPS VFSEMSSDYA QPSATTVAED EDKEDEFGYS 1320
WKNIQERYGT LTGQLHMIEL EKGHSGLGLS LAGNKDRTRM SVFIVGIDPT GAAGRDGRLQ 1380
IADELLEING QILYGRSHQN ASSIIKCAPS KVKIIFIRNA DAVNQMAVCP GSAADPLPST 1440
SESPQNKEVE PSITTSASAV DLSSLTNVYH LELPKDQGGL GIAICEEDTL NGVTIKSLTE 1500
RGGAAKDGRL KPGDRILAVD DELVAGCPIE KFISLLKTAK TTVKLTVGAE NPGCQAVPSA 1560
AVTASGERKD SSQTPAVPAP DLEPIPSTSR SSTPAIFASD PATCPIIPGC ETTIEISKGQ 1620
TGLGLSIVGG SDTLLGAIII HEVYEEGAAC KDGRLWAGDQ ILEVNGIDLR KATHDEAINV 1680
LRQTPQRVRL TLYRDEAPYK EEDVCDTFTV ELQKRPGKGL GLSIVGKRND TGVFVSDIVK 1740
GGIADADGRL MQGDQILMVN GEDVRNATQE AVAALLKCSL GTVTLEVGRI KAAPFHSERR 1800
PSQSSQVSES SLSSFSLPRS GIHTSESSES SAKKNALASE IQGLRTVEIK KGPADALGLS 1860
IAGGVGSPLG DVPIFIAMMH PNGVAAQTQK LRVGDRIVTI CGTSTDGMTH TQAVNLMKNA 1920
SGSIEVQVVA GGDVSVVTGH QQELANPCLA FTGLTSSTIF PDDLGPPQSK TITLDRGPDG 1980
LGFSIVGGYG SPHGDLPIYV KTVFAKGAAA EDGRLKRGDQ IIAVNGQSLE GVTHEEAVAI 2040
LKRTKGTVTL MVLS 2055
Keyword

KW-0002--3D-structure
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0771--Synaptosome
KW-0796--Tight junction
Interpro

IPR015132--L27_2
IPR004172--L27_dom
IPR032078--MPDZ
IPR001478--PDZ
PROSITE

PS51022--L27
PS50106--PDZ
Pfam

PF09045--L27_2
PF16667--MPDZ_u10
PF00595--PDZ
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005923--C:bicellular tight junction
GO:0030425--C:dendrite
GO:0012505--C:endomembrane system
GO:0005622--C:intracellular
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0035556--P:intracellular signal transduction
GO:0042552--P:myelination