| Tag |
Content |
| dbPAF ID |
dbPAF-0001942 |
| Uniprot Accession |
O55145; X3CL1_RAT;
|
| Genbank Protein ID |
NP_604450.1;
|
| Genbank Nucleotide ID |
NM_134455.1;
|
| Protein Name |
Fractalkine |
| Protein Synonyms/Alias |
C-X3-C motif chemokine 1;CX3C membrane-anchored chemokine;Neurotactin;Small-inducible cytokine D1; |
| Gene Name |
Cx3cl1 |
| Gene Synonyms/Alias |
Acc1;Fkn;Scyd1; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.Functional Description
The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 142 | EDLTLEPTAISQEAR | curated | 23984901 |
|
Sequence
(Fasta) | MAPSQLAWLL RLAAFFHLCT LLAGQHLGMT KCNITCHKMT SPIPVTLLIH YQLNQESCGK 60
RAIILETRQH RHFCADPKEK WVQDAMKHLD HQTAALTRNG GKFEKRVDNV TPRITSATRG 120
LSPTALAKPE SATVEDLTLE PTAISQEARR PMGTSQEPPA AVTGSSPSTS KAQDAGLAAK 180
PQSTGISEVA AVSTTIWPSS AVYQSGSSLW AEEKATESPP TIALSTQAST TSSPKQNVGS 240
EGQPPWVQEQ DSTPEKSPGP EETNPVHTDI FQDRGPGSTV HPSVAPTSSE KTPSPELVAS 300
GSQAPKVEEP IHATADPQKL SVFITPVPDS QAATRRQAVG LLAFLGLLFC LGVAMFAYQS 360
LQGCPRKMAG EMVEGLRYVP RSCGSNSYVL VPV
394Fasta Sequence
>O55145|Cx3cl1|Rattus norvegicus(Rat)
MAPSQLAWLLRLAAFFHLCTLLAGQHLGMTKCNITCHKMTSPIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLDHQTAALTRNGGKFEKRVDNVTPRITSATRGLSPTALAKPESATVEDLTLEPTAISQEARRPMGTSQEPPAAVTGSSPSTSKAQDAGLAAKPQSTGISEVAAVSTTIWPSSAVYQSGSSLWAEEKATESPPTIALSTQASTTSSPKQNVGSEGQPPWVQEQDSTPEKSPGPEETNPVHTDIFQDRGPGSTVHPSVAPTSSEKTPSPELVASGSQAPKVEEPIHATADPQKLSVFITPVPDSQAATRRQAVGLLAFLGLLFCLGVAMFAYQSLQGCPRKMAGEMVEGLRYVPRSCGSNSYVLVPV
|
| Keyword |
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0145--Chemotaxis
KW-0181--Complete proteome
KW-0202--Cytokine
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0472--Membrane
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR001811--Chemokine_IL8-like_dom
IPR008097--CX3CL1
|
| PROSITE |
|
| Pfam |
PF00048--IL8
|
| Gene Ontology |
GO:0042995--C:cell projection
GO:0005737--C:cytoplasm
GO:0005615--C:extracellular space
GO:0016021--C:integral component of membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0048020--F:CCR chemokine receptor binding
GO:0008009--F:chemokine activity
GO:0007568--P:aging
GO:0007155--P:cell adhesion
GO:0071346--P:cellular response to interferon-gamma
GO:0071347--P:cellular response to interleukin-1
GO:0071356--P:cellular response to tumor necrosis factor
GO:0070098--P:chemokine-mediated signaling pathway
GO:0006935--P:chemotaxis
GO:0048245--P:eosinophil chemotaxis
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0060080--P:inhibitory postsynaptic potential
GO:0048247--P:lymphocyte chemotaxis
GO:0001774--P:microglial cell activation
GO:0002548--P:monocyte chemotaxis
GO:0050710--P:negative regulation of cytokine secretion
GO:0045906--P:negative regulation of vasoconstriction
GO:0030593--P:neutrophil chemotaxis
GO:0030168--P:platelet activation
GO:0045785--P:positive regulation of cell adhesion
GO:0030335--P:positive regulation of cell migration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043547--P:positive regulation of GTPase activity
GO:0050729--P:positive regulation of inflammatory response
GO:0010759--P:positive regulation of macrophage chemotaxis
GO:0002052--P:positive regulation of neuroblast proliferation
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0001666--P:response to hypoxia
|
