dbPAF Protein Information
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dbPAF ID | dbPAF-0001922 | ||||||||||||||||||||||||||||||||
Uniprot Accession | O55081; RBL2_RAT; | ||||||||||||||||||||||||||||||||
Genbank Protein ID | NP_112356.1; | ||||||||||||||||||||||||||||||||
Genbank Nucleotide ID | NM_031094.1; | ||||||||||||||||||||||||||||||||
Protein Name | Retinoblastoma-like protein 2 | ||||||||||||||||||||||||||||||||
Protein Synonyms/Alias | 130 kDa retinoblastoma-associated protein;p130;PPAR-alpha-interacting complex protein 128;PRIC128;Retinoblastoma-related protein 2;RBR-2;pRb2; | ||||||||||||||||||||||||||||||||
Gene Name | Rbl2 | ||||||||||||||||||||||||||||||||
Gene Synonyms/Alias | |||||||||||||||||||||||||||||||||
Organism | Rattus norvegicus(Rat) | ||||||||||||||||||||||||||||||||
NCBI Taxa ID | 10116 | ||||||||||||||||||||||||||||||||
Functional Description (View all) |
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor (By similarity). | ||||||||||||||||||||||||||||||||
Phosphorylation Sites |
dbPAF PTMs: 7
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Sequence (Fasta) | MASGGNQSSP PPPAAAASSE EEEEDGDTAD RAQPAGSPSH QIQQRFEELC SRLNMDEAAR 60 AEAWSSYRSM SESYTLEGND LHWLACALYV ACRKSVPTVS KGTAEGNYVS LTRILRCSEQ 120 SLIEFFNKMK KWEDMANLPP HFRERTERLE RNFTVSAVIF KKYEPIFQDI FKYPQEEQPR 180 QQRGRKQRRQ PCTTSEIFHF CWVLFIYAKG NFPMISDDLV NSYHLLLCAL DLVYGNALQC 240 SNRKELVNPN FKGVSEDGHP RDSHPSSDPP CVIEKLCSLH DGLVLEAKGI KQHFWKPYIR 300 KLFEKKLLRG KEENLTGFLE PGNFAESFKA VNKAYEEYVL ATGSLDERIF LGEDAEEEVG 360 TFSRCVSAAS GTESAERTQM RDILQQHLDK SKTLRVCNPL TGVRYVQENS PCVTPVSTAT 420 HSLNRLHTML AGLRNAPSEK LEQILRSCSR DPTRAIADRL REMYEIYSQH FQPDENVSNC 480 AKEMANKHFR FAEMLYYKVL ESVIEQEQKR LGDMDLSGVL EQDAFHKSLL ACCLEVVAFS 540 YKPPGNFPFI AEIFDVPHYH FYKVIEVFIR AEDGLCREVV KHLNQIEEQI LDHLAWKTKS 600 PLWDRIRDNE NRVPTCEEVT PPHNLERTDE IYIAGSPLTP RRVGEVRTDA GGLGRSVTSP 660 TTLYDRYSSP TVSTTRRRLF ESDSPSEGST AGRIPPQPLV NAVPVQNVSG ETVSVTPVPG 720 QTLVTMATAT VTANNGQTVT IPVQGIANEN GGITFFPVQV NVGGQAQAVT GSIQPLSAQA 780 LAGSLSSQQV TGTTLQVPGP VAIQQISPGG QQQNQGQPLT SSSIRPRKTS SLSLFFRKVY 840 YLAGVRLRDL CTKLDISDEL RKKIWTCFEF SIVQCPELMM DRHLDQLLMC AIYVMAKVTK 900 EDKSFQNIMR CYRTQPQARS QVYRSVLIKG KRRNSGSCEN RSHQNSPTEL NTDRASRDSS 960 PVMRSNSTLP VPQPSSAPPT PTRLTGANSD IEEEERGDLI QFYNNIYRKQ IQTFAMKYSQ 1020 ANSQMDTPPL SPYPFVRTGS PRRVQLSQSH PIYISPHKNE AMLSPREKIF YYFSNSPSKR 1080 LREINSMIRT GETPTKKRGI LLDDGSESPA KRICPENHSA LLRRLQDVAN DRGSH 1136 |
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Keyword | KW-0131--Cell cycle |
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Interpro | IPR013763--Cyclin-like |
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PROSITE | |||||||||||||||||||||||||||||||||
Pfam | |||||||||||||||||||||||||||||||||
Gene Ontology | GO:0000785--C:chromatin |