dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001918
Uniprot Accession O55043; ARHG7_RAT;
Genbank Protein ID NP_001106994.1;
Genbank Nucleotide ID NM_001113522.1;
Protein Name Rho guanine nucleotide exchange factor 7
Protein Synonyms/Alias Beta-Pix;PAK-interacting exchange factor beta;
Gene Name Arhgef7
Gene Synonyms/Alias Pak3bp;Pixb;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
7-MTDNANSQLVVRAKPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
66YVREIKPSEKPVSPKcurated25532521
71KPSEKPVSPKSGTLKPhosphoSitePlus;UniProt;curated22135298; 22673903; 22276854
79PKSGTLKSPPKGFDTPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
340LSASPRMSGFIYQGKdbPTM 3.0;PhosphoSitePlus;UniProt;curated17089331; 16381945; 23193290; 22135298; 22673903; 25532521;
498YKEDLSRSPKTMKKLPhosphoSitePlus22135298
516RKPERKPSDEEFAVRdbPTM 3.0;PhosphoSitePlus;UniProt;curated15513924; 18160719; 18184567; 16381945; 23193290; 22135298;
525EEFAVRKSTAALEEDcurated23984901
526EFAVRKSTAALEEDAdbPTM 3.0;PhosphoSitePlus;curated15513924; 18160719; 18184567; 16381945; 23193290; 22135298;
560NSSSRKESAPQVLLPPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
Sequence
(Fasta)		MTDNANSQLV VRAKFNFQQT NEDELSFSKG DVIHVTRVEE GGWWEGTHNG RTGWFPSNYV 60
REIKPSEKPV SPKSGTLKSP PKGFDTTAIN KSYYNVVLQN ILETEHEYSK ELQSVLSTYL 120
WPLQTSEKLS SANTSYLMGN LEEISSFQQV LVQSLEECTK SPEAQQRVGG CFLSLMPQMR 180
TLYLAYCANH PSAVSVLTEH SEDLGEFMET KGASSPGILV LTTGLSKPFM RLDKYPTLLK 240
ELERHMEDYH PDRQDIQKSM TAFKNLSAQC QEVRKRKELE LQILTEPIRS WEGDDIKTLG 300
SVTYMSQVTI QCAGSEEKNE RYLLLFPNLL LMLSASPRMS GFIYQGKLPT TGMTITKLED 360
SENHRNAFEI SGSMIERILV SCNNQQDLHE WVEHLQRQTK VTSVSNPTIK PHSVPSHTLP 420
SHPLTPSSKH ADSKPVALTP AYHTLPHPSH HGTPHTTISW GPLEPPKTPK PWSLSCLRPA 480
PPLRPSAALC YKEDLSRSPK TMKKLLPKRK PERKPSDEEF AVRKSTAALE EDAQILKVIE 540
AYCTSAKTRQ TLNSSSRKES APQVLLPEEE KIIVEETKSN GQTVIEEKSL VDTVYALKDE 600
VQELRQDNKK MKKSLEEEQR ARKDLEKLVR KVLKNMNDPA WDETNL 647
Keyword

KW-0002--3D-structure
KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0344--Guanine-nucleotide releasing factor
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3
Pfam

PF16523--betaPIX_CC
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2
Gene Ontology

GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0005925--C:focal adhesion
GO:0030426--C:growth cone
GO:0030027--C:lamellipodium
GO:0001726--C:ruffle
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0019901--F:protein kinase binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043615--P:astrocyte cell migration
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0043547--P:positive regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction