dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001914
Uniprot Accession O55035; PPIG_RAT; Q5U346;
Genbank Protein ID NP_113981.1;
Genbank Nucleotide ID NM_031793.1;
Protein Name Peptidyl-prolyl cis-trans isomerase G
Protein Synonyms/Alias
Gene Name Ppig
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
173FAEVRILSCGELVPKcurated23984901
193EEKKRHKSSSSSSSSdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
198HKSSSSSSSSDSDSSdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
200SSSSSSSSDSDSSSDdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
204SSSSDSDSSSDSQSSdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
206SSDSDSSSDSQSSSDdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
254KKSKKSPSSESEADNPhosphoSitePlus;curated22135298; 23712012; 21630457
255KSKKSPSSESEADNVPhosphoSitePlus;curated22135298; 23712012; 21630457
257KKSPSSESEADNVDAPhosphoSitePlus;curated22135298; 23712012; 21630457
288NRFLMRKSPPKADDKPhosphoSitePlus;curated22135298; 23712012; 21630457
341RGPRRYRTPSRSRSRPhosphoSitePlus22135298
343PRRYRTPSRSRSRDRPhosphoSitePlus22135298
354SRDRFRRSETPPHWRdbPTM 3.0;PhosphoSitePlus;UniProt;curated16641100; 16381945; 23193290; 22135298; 22817900; 21630457
356DRFRRSETPPHWRQEdbPTM 3.0;PhosphoSitePlus;UniProt;curated16641100; 16381945; 23193290; 22135298; 25532521; 22817900;
395EIKENQRSPVRVKEKPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521; 23712012; 21630457; 22276854
411ITDHRHMSESPNRKIPhosphoSitePlus;curated22135298; 23712012; 21630457
413DHRHMSESPNRKIEKPhosphoSitePlus;curated22135298; 23712012; 21630457
685KKADIDQSPVSKTKQPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521; 22817900; 21630457; 22276854
688DIDQSPVSKTKQSSQcurated23712012; 21630457
712KNQEDEKTRSPVEKEcurated23712012; 21630457
Sequence
(Fasta)		MGIKVQRPRC FFDIAINNQP AGRVVFELFS DVCPKTCENF RCLCTGEKGT GKSTQKPLHY 60
KSCLFHRVVK DFMVQGGDFS EGNGRGGESI YGGFFEDESF AVKHNKEFLL SMANRGKDTN 120
GSQFFITTKP TPHLDGHHVV FGQVISGQEV VREIENQKTD AASKPFAEVR ILSCGELVPK 180
SKVKKEEKKR HKSSSSSSSS DSDSSSDSQS SSDSSDSESA SEEKSRKRKK KHRKNSRKHK 240
KEKKKRKKSK KSPSSESEAD NVDAQPQSTV RPEEIPPIPE NRFLMRKSPP KADDKERKNR 300
ERERERECNP PNSQPASYQR RFLVTRFGRK IKGRGPRRYR TPSRSRSRDR FRRSETPPHW 360
RQEMQRAQRM RVSSGERWIK GDKSELNEIK ENQRSPVRVK EKKITDHRHM SESPNRKIEK 420
EKKVKDHKSE SKERDIRRNS EKDDKYNKNK VKKRGKSKSR SKSKERSKSK ERDSKHSRHE 480
DKRVRSRSKE RDHETTKEKE KQLDSKGKDQ ERSRSKENSK QVESKSNEHD HSKSKEKDRR 540
AQSRSRERDL TKSKHSYNSR TRERSRSRDR SRRVRSRSHD RDRSRSKEYH RYREQEYRRR 600
GRSRSRDRRT PGRSRSKDRR RRRRDSRSSE REESQSRNKE KYRSQDSKSS HRKENSEGEK 660
RMYSKSRDHS SSNNNREKKA DIDQSPVSKT KQSSQDNEVK SSTLKNQEDE KTRSPVEKEN 720
QKSKGQENDH VHDKNKKCDH ESSPGTDEDK SG 753
Keyword

KW-0181--Complete proteome
KW-0413--Isomerase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0697--Rotamase
Interpro

IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
Pfam

PF00160--Pro_isomerase
Gene Ontology

GO:0016363--C:nuclear matrix
GO:0016607--C:nuclear speck
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0006457--P:protein folding
GO:0000413--P:protein peptidyl-prolyl isomerization