dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001907
Uniprot Accession O55012; PICAL_RAT; O55011;
Genbank Protein ID NP_446006.1;
Genbank Nucleotide ID NM_053554.2;
Protein Name Phosphatidylinositol-binding clathrin assembly protein
Protein Synonyms/Alias Clathrin assembly lymphoid myeloid leukemia protein;rCALM;
Gene Name Picalm
Gene Synonyms/Alias Calm;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
20AQHSVTGSAVSKTVCcurated23984901
96GNERFIQYLASRNTLPhosphoSitePlus22135298
107RNTLFNLSNFLDKSGPhosphoSitePlus22135298
158GADGVMRTMNTEKLLPhosphoSitePlus22135298
301TAASRATTLSNAVSScurated23712012; 21630457
303ASRATTLSNAVSSLAdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated16641100; 16381945; 23193290; 22135298; 19366988; 23712012;
307TTLSNAVSSLASTGLdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated16641100; 16381945; 23193290; 22135298; 19366988; 23712012;
308TLSNAVSSLASTGLSdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated16641100; 16381945; 23193290; 22135298; 19366988; 23712012;
312AVSSLASTGLSLTKVdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated16641100; 16381945; 23193290; 22135298; 19366988; 23712012;
561QPGEKKLTGGSNWQPcurated23984901
Sequence
(Fasta)		MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA 60
DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM 120
STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD 180
FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF 240
LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT 300
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTTAASP 360
VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT FHPSVHAMSA APQVASTWGD 420
AVDDAIPSLN PFLTKSSGDV HLPISSDVST FTTRTPTHEM FVGFSPSPVT QPHPSAGLNV 480
DFESVFGNKS TNVAVDSGGG LLKPTVASQN QSLPVAKLPP NKLVSDDLDS SLANLVGNLG 540
IGNGTTKNDV SCSQPGEKKL TGGSNWQPKV APTTAWSAAT MAPPVMAYPA TTPTGMIGYG 600
IPPQMGSVPV MTQPTLIYSQ PVMRPPNPFG PVPGAQIQFM 641
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0333--Golgi apparatus
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR011417--ANTH_dom
IPR014712--Clathrin_AP_2
IPR013809--ENTH
IPR008942--ENTH_VHS
IPR030412--PICALM
PROSITE

PS50942--ENTH
Pfam

PF07651--ANTH
Gene Ontology

GO:0030136--C:clathrin-coated vesicle
GO:0005905--C:coated pit
GO:0005768--C:endosome
GO:0005794--C:Golgi apparatus
GO:0097418--C:neurofibrillary tangle
GO:0043025--C:neuronal cell body
GO:0097481--C:neuronal postsynaptic density
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0045211--C:postsynaptic membrane
GO:0042734--C:presynaptic membrane
GO:0045202--C:synapse
GO:0008021--C:synaptic vesicle
GO:0031982--C:vesicle
GO:0005545--F:1-phosphatidylinositol binding
GO:0035615--F:clathrin adaptor activity
GO:0030276--F:clathrin binding
GO:0042802--F:identical protein binding
GO:0017124--F:SH3 domain binding
GO:0007409--P:axonogenesis
GO:0035459--P:cargo loading into vesicle
GO:0008283--P:cell proliferation
GO:0048268--P:clathrin coat assembly
GO:0072583--P:clathrin-mediated endocytosis
GO:0048813--P:dendrite morphogenesis
GO:0055072--P:iron ion homeostasis
GO:0097459--P:iron ion import into cell
GO:0010629--P:negative regulation of gene expression
GO:1902963--P:negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902961--P:positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902004--P:positive regulation of beta-amyloid formation
GO:1901216--P:positive regulation of neuron death
GO:0006898--P:receptor-mediated endocytosis
GO:1902959--P:regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:0030100--P:regulation of endocytosis
GO:0051223--P:regulation of protein transport
GO:0016188--P:synaptic vesicle maturation
GO:0016192--P:vesicle-mediated transport