dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001906
Uniprot Accession O55007; RGPA1_RAT; F1LSW3; O55008;
Genbank Protein ID NP_064468.3;
Genbank Nucleotide ID NM_020083.3;
Protein Name Ral GTPase-activating protein subunit alpha-1
Protein Synonyms/Alias GAP-related-interacting partner to E12;GRIPE;GTPase-activating RapGAP domain-like 1;Tuberin-like protein 1;p240;
Gene Name Ralgapa1
Gene Synonyms/Alias Garnl1;Tulip1;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
753RSIVRQKTVDIDDSQPhosphoSitePlus22135298
772STRVRHFSQSEDTGNPhosphoSitePlus;curated22135298; 23712012; 21630457; 23984901
774RVRHFSQSEDTGNEVcurated23712012; 21630457
795EQPLPRSSSTSDILEcurated23712012; 21630457
796QPLPRSSSTSDILEPPhosphoSitePlus;UniProt;curated22135298; 22673903; 21630457
797PLPRSSSTSDILEPFcurated23712012; 21630457
798LPRSSSTSDILEPFTcurated23984901
859STMTRRGSSPGSLEIPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
860TMTRRGSSPGSLEIPPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
863RRGSSPGSLEIPKDLPhosphoSitePlus;UniProt22135298; 22673903
999HSALGSRSQTPSPSTPhosphoSitePlus;UniProt22135298; 22673903
1001ALGSRSQTPSPSTLNPhosphoSitePlus;UniProt22135298; 22673903
1003GSRSQTPSPSTLNIDPhosphoSitePlus;UniProt22135298; 22673903
1477REPEPLHSPDSERSSPhosphoSitePlus;UniProt22135298; 22673903
Sequence
(Fasta)		MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENADS IDLKQFFDQH FSHIYYVFFE 60
NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN 120
SLKIRREGVR LFLLWLQALQ DNCSKEQLWM FSCLIPGFSA PQSEYGPRTL DNLINPPLNL 180
QETQVTIEEV TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL 240
FSHFKKFYLP YIFPNLCKEN SLYHPVLDIP QVRPKPHYVM VKKDAETNET IYCTKEPFIQ 300
ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK NDTVDKADKT 360
AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL 420
LPICEAAAMR KVVKVYQEWI QQEGKPLFMQ EPEETVITSS DIPCSENVTD HDISIEDGEK 480
REEENGTNIS EHVRNSTWTK NGSYQEAFHV SEEATEQNIQ AGTQAVLQVF IINSSNIFLL 540
EPANEIKNLL DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF 600
LQFQGKKNMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS LTYWEELATE 660
WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK GVGHEFQKVS VDKSFSRGWS 720
RDQPGQAPMR QRSATTTGSP GTEKARSIVR QKTVDIDDSQ ILPRSTRVRH FSQSEDTGNE 780
VFGALHEEQP LPRSSSTSDI LEPFTVERAK VNKEDTSPKL PPLNSETGGS SANVPDLMDE 840
FIAERLRSGN ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS 900
SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DSGSGHHQST EEQEVASLTT 960
LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ TPSPSTLNID HMEQKDLQLD 1020
EKLHHSVLQT PDDLEISEFP SECCSVMAGG TLTGWHADVA TVMWRRMLGI LGDVNAIMDP 1080
EIHAQVFDYL CELWQNLAKI RDNLGISADN LTSPSPPVLI PPLRILTPWL FKATMLTDKY 1140
KQGKLHAYKL ICNTMKRRQD VSPNRDFLTH FYNIMHCGLL HIDQDIVNTI IKHCSPQFFS 1200
LGLPGATMLI MDFIIAAGRV ASSAFLNAPR VEAQVLLGSL VCFPNLYCEL PALHPSTPDI 1260
AVSQFTDVKE LIIKTVLSSA RDEPSGPARC VALCSLGIWI CEELVHESHH PQIKEALNVI 1320
CVSLKFTNKT VAHVACNMLH MLVHYAPRLQ TYQPDSPLKI IQILIATITH LLPSTEASSY 1380
EMDKRLVVSL LLCLLDWIMA LPLKTLLQSV HSTGAENEKT EKSVLNCIYK VLHGCVYGAQ 1440
SFSHPKYFPI SLSDLASVDY DPFMHLESLR EPEPLHSPDS ERSSKLQPVT EVKTQMQQGL 1500
ISIAARTVIT HLVNHLGHYP MSGGPAMLTS QVCENHDNHY SESTELSPEL FDSPNIQFFV 1560
LNNTTLVSCI QIRSEESVPG GGLAAGLVSA NSNVRIIVRD LSGKYSWDSA ILYGPPIVSG 1620
LPEPTSFILS MSYQEKPEEP PTSNECLEDI TVKDGLSLQL RRFRETVPTW STIREEEDVL 1680
DELLQYLGTT SPECLQRTGI SLNVPAPQPV CISEKQENDV INAILKQYTE EKEFVEKHFN 1740
DLNMKASEQD EPTPQKPQSA FYYCRLLLSI LGMNSWDKRR SFHLLKKNEK LLRELRNLDS 1800
RQCRETHKIA VFYVAEGQED KYSILTNIGG SQAYEDFVAG LGWEVNLTNH CGFMGGLQKN 1860
KSTGLTTPYF ATSTVEVIFH VSTRMPSESD DSLTKKLRHL GNDEVHIVWS EHTRDYRRGI 1920
IPTEFGDVLI VIYPMKNHMF SIQIMKKPEV PFFGPLFDGA IVNGKVLPIM VRSTAINASR 1980
ALKSLIPLYQ NLYEERARYL QTIVQHHLEP TTFEDFAAQV FSPAPYHHFP ADADH 2036
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0343--GTPase activation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR016024--ARM-type_fold
IPR000331--Rap_GAP_dom
PROSITE

PS50085--RAPGAP
Pfam

PF02145--Rap_GAP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005096--F:GTPase activator activity
GO:0090630--P:activation of GTPase activity
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0006355--P:regulation of transcription, DNA-templated